|
T-Cell Lymphoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Combinatorial ixazomib and belinostat therapy induces NFE2L2-dependent apoptosis in Hodgkin and T-cell lymphoma.
|
31452195 |
2020 |
|
Polycystic Kidney, Autosomal Dominant
|
0.010 |
Biomarker
|
disease |
BEFREE |
Several Nrf2 activators are at various stages of clinical development and are being tested in clinical trials for chronic kidney disease (CKD) including diabetic kidney disease, Alport syndrome, autosomal dominant polycystic kidney disease and focal segmental glomerulosclerosis.
|
31592832 |
2020 |
|
Pancreatitis, Chronic
|
0.010 |
Biomarker
|
disease |
BEFREE |
Reducing Pancreatic Fibrosis Using Antioxidant Therapy Targeting Nrf2 Antioxidant Pathway: A Possible Treatment for Chronic Pancreatitis.
|
31688588 |
2020 |
|
Cyclic neutropenia
|
0.010 |
Biomarker
|
disease |
BEFREE |
Taken together, our results suggested that early administration of losartan after CN injury could slightly improve erectile function and significantly reduce corporal apoptosis and oxidative stress by inhibiting the Akt/Bad/Bax/caspase-3 and Nrf2/Keap-1 pathways.
|
30880689 |
2020 |
|
Maladaptive behavior associated with physical illness
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
Our findings suggest that obesity results in Nrf2 dysfunction which likely causes maladaptation to oxidative stress and inflammation in the RVLM.
|
31823672 |
2020 |
|
Visceral Pain
|
0.010 |
AlteredExpression
|
phenotype |
BEFREE |
Nrf2 mediates the antinociceptive activity of dexmedetomidine in an acute inflammatory visceral pain rat model by activating the NF-κB sensor.
|
31773760 |
2020 |
|
Thyroid associated opthalmopathies
|
0.010 |
Biomarker
|
disease |
BEFREE |
Our initial findings in GO mice were that PD attenuated orbital muscle adipose tissue expansion and lipid droplet accumulation through a nuclear factor E2-related factor 2 (NRF2)-mediated oxidative stress response involving the Keap1/Nrf2/ARE pathway.
|
31705858 |
2020 |
|
Congenital Abnormality
|
0.010 |
Biomarker
|
group |
BEFREE |
After knocking down Nrf2 in zebrafish embryos, the rates of mortality and malformation were markedly increased and the hatching rate was significantly decreased.
|
31022495 |
2019 |
|
Abscess
|
0.010 |
GeneticVariation
|
phenotype |
BEFREE |
Experimental Scedosporiosis Induces Cerebral Oedema Associated with Abscess regarding Aquaporin-4 and Nrf-2 Depletions.
|
31080825 |
2019 |
|
Adenovirus Infections
|
0.010 |
AlteredExpression
|
group |
BEFREE |
Nrf2 was knocked down through adenovirus infection, and successful knockdown was confirmed by Western blot analysis and quantitative polymerase chain reaction.
|
31075320 |
2019 |
|
Ataxia Telangiectasia
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Activation of NRF2 by dexamethasone in ataxia telangiectasia cells involves KEAP1 inhibition but not the inhibition of p38.
|
31107893 |
2019 |
|
Autistic Disorder
|
0.010 |
Biomarker
|
disease |
BEFREE |
Sulforaphane activates Nrf2 and thus is considered a potential approach to treat several neurological disorders including autism.
|
30790585 |
2019 |
|
Carcinoid Tumor
|
0.010 |
PosttranslationalModification
|
phenotype |
BEFREE |
The epigenetic deregulation of the KEAP1/NRF2 by a KEAP1 promoter hypermethylation system appears to be a frequent event in lung carcinoids.
|
31126053 |
2019 |
|
Cholangitis
|
0.010 |
Biomarker
|
disease |
BEFREE |
Diet containing 3,5-diethoxycarbonyl-1,4-dihydrocollidine (DDC) was fed to Nrf2-KO mice (Nrf2-/-), mice with liver-specific hyperactivated Nrf2 (HKeap1-/-) and wild-type (WT) littermates to induce cholangitis, liver fibrosis, and oval cell expansion.
|
30825315 |
2019 |
|
Cholangitis, Sclerosing
|
0.010 |
Biomarker
|
disease |
BEFREE |
Here, we investigated whether Nrf2 protects from sclerosing cholangitis and biliary fibrosis and simultaneously induces liver regeneration.
|
30825315 |
2019 |
|
Constipation
|
0.010 |
AlteredExpression
|
phenotype |
BEFREE |
Loss of Nrf2/BH<sub>4</sub>/nNOS expression in PD impairs antioxidant gene expression, which deregulates NO synthesis, thereby contributing to the development of GI dysmotility and constipation.
|
31187328 |
2019 |
|
Eczema
|
0.010 |
Biomarker
|
disease |
BEFREE |
Western blot assays revealed that the expression levels of nuclear factor‑E2‑related factor 2 (Nrf2) and heme oxygenase-1 (HO‑1), which exhibit oxidation resistance, were increased by sulforaphane treatment in DNCB‑induced AD mice.
|
31257541 |
2019 |
|
Membranous glomerulonephritis
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
The protective effect of ILQ on MGN can be explained by its anti-oxidative and anti-inflammatory activities, which in turn due to the activation of Nrf2 and downregulation of NF-κB pathway.
|
31802848 |
2019 |
|
Hamartoma Syndrome, Multiple
|
0.010 |
Biomarker
|
disease |
BEFREE |
Furthermore, Cd, but not Zn, significantly activated Nrf2 and its downstream targets, including HO-1; inhibition of HO-1 by a specific HO-1 inhibitor, ZnPP (10 µM), significantly increased Cd-induced toxicity, but did not inhibit Zn protection against Cd injury, suggesting that Nrf2-mediated HO-1 activation was not required for Zn protective effect.
|
31768045 |
2019 |
|
Hepatic Encephalopathy
|
0.010 |
Biomarker
|
disease |
BEFREE |
Taken together, the protective effect of Magnesium Isoglycyrrhizinate on EPI-induced hepatic encephalopathy might be mediated via the Txnip/Nrf2/NF-κB signaling pathway.
|
31351363 |
2019 |
|
Genital Herpes
|
0.010 |
Biomarker
|
disease |
BEFREE |
Nrf2 Negatively Regulates Type I Interferon Responses and Increases Susceptibility to Herpes Genital Infection in Mice.
|
31555293 |
2019 |
|
Hyperalgesia
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
In the present research, neuropathic pain induced Nrf2 and HO-1 expression in the microglial cells of the spinal cord; Nrf2 and HO-1 were necessary to alleviate the hyperalgesia of CCI-induced rats; NaHS mitigated the hyperalgesia and allodynia induced by the CCI operation; and NaHS mitigated the excessive release of the cytokines TNF-α, IL-1β, IL-6 and HMGB1 via the Nrf2/HO-1 pathway in the microglial cells of the spinal cord.
|
31325725 |
2019 |
|
Hyperthyroidism
|
0.010 |
PosttranslationalModification
|
disease |
BEFREE |
The hyperthyroidism increased the phosphorylation levels of Nrf2 (nuclear factor erythroid 2-related factor) and the kinase activity of protein kinase C (PKC) and extracellular signal-regulated kinase (ERK).
|
31281590 |
2019 |
|
Arthropathy
|
0.010 |
Biomarker
|
group |
BEFREE |
Further studies are necessary to identify improved strategies to regulate Nrf2 and HO-1 activation in order to enable the development of drugs with therapeutic applications in joint diseases.
|
31830562 |
2019 |
|
Kidney Calculi
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Inhibiting inflammation and modulating oxidative stress in oxalate-induced nephrolithiasis with the Nrf2 activator dimethyl fumarate.
|
30599261 |
2019 |