|
Diabetes
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Redox homeostasis is tightly controlled by the transcriptional factor nuclear factor erythroid 2-related factor 2 (Nrf2), whose abnormality is believed to be related with diabetes.
|
21861804 |
2011 |
|
Diabetes
|
0.100 |
Biomarker
|
disease |
BEFREE |
We conclude that Nrf2 activation accelerates impaired wound healing by ameliorating diabetes-mediated oxidative stress and inflammation.
|
31616304 |
2019 |
|
Diabetes
|
0.100 |
Biomarker
|
disease |
BEFREE |
The purpose of this study is to determine whether fenofibrate protects retinas from oxidative damage and neuroinflammation via modulating the Nrf2 pathway and blocking NLRP3 inflammasome activation during diabetes.
|
29264825 |
2018 |
|
Diabetes
|
0.100 |
Biomarker
|
disease |
BEFREE |
We also demonstrated the critical roles of the Nrf2 and NF-κB pathways in diabetes-stimulated cardiac injuries and indicated that they may be key therapeutic targets for diabetic complications.
|
28982613 |
2018 |
|
Diabetes
|
0.100 |
Biomarker
|
disease |
BEFREE |
The Kelch-like erythroid-associated protein 1 (Keap1)-NF-E2-related factor 2 (Nrf2) signaling pathway is the subject of several clinical trials evaluating the effects of Nrf2 activation on the prevention of cancer and diabetes and the treatment of chronic kidney disease and multiple sclerosis.
|
29367259 |
2018 |
|
Diabetes
|
0.100 |
Biomarker
|
disease |
BEFREE |
We have previously shown that dysfunction of the Nuclear factor (erythroid-derived 2)-like 2 (Nrf2)/ Kelch-like erythroid cell-derived protein 1 (Keap1) signaling pathway leads to extreme ROS imbalance during cutaneous wound healing in diabetes.
|
30507922 |
2018 |
|
Diabetes
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
A growing body of evidences now suggests that strategies utilizing a more targeted approach like focusing on Nrf2 (a transcription factor modulating oxidative stress) may provide an enthralling avenue to optimize neuroprotection in diabetes and diabetic neuropathy.
|
21439933 |
2011 |
|
Diabetes
|
0.100 |
Biomarker
|
disease |
BEFREE |
In previous studies, the widely used diabetes drug metformin has appeared to have a critical role in the regulation of Nrf2 function.
|
30803422 |
2019 |
|
Diabetes
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
With yearly increases in the global incidence of cardiovascular diseases (CVD) and diabetes, numerous studies have focused on characterizing whether upregulating antioxidant defenses through exogenous antioxidants (e.g. vitamin E, vitamin C) or activation of endogenous defenses (e.g. the Nuclear factor erythroid 2-related factor 2 (Nrf2) antioxidant defense pathway) may be of benefit.
|
29427794 |
2018 |
|
Diabetes
|
0.100 |
Biomarker
|
disease |
BEFREE |
Nrf2 knockout mice exhibited early onset of blood-retina barrier dysfunction and exacerbation of neuronal dysfunction in diabetes.
|
24186494 |
2014 |
|
Diabetes
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Thus, the aim of this study was to explore if polymorphisms in Nrf2 and target genes are associated with diabetes and obesity in Mexican mestizo subjects.The rs1800566 of
|
27274779 |
2016 |
|
Diabetes
|
0.100 |
Biomarker
|
disease |
BEFREE |
Given the pathogenic role of mitochondrial oxidative stress in diabetes-related microvascular complications, we focused on assessing: 1) the impact of diabetes on brain Nrf2 in correlation with BBB permeability and 2) Nrf2-dependent regulation of the mitochondrial transporter ABCB10, an essential player in mitochondrial function and redox balance at BBB endothelium.
|
28572033 |
2017 |
|
Diabetes
|
0.100 |
Biomarker
|
disease |
BEFREE |
SF or CA significantly attenuated common metabolic disorder symptoms associated with diabetes in Nrf2(+/+) but not in Nrf2(-/-) mice, indicating SF and CA function through specific activation of the Nrf2 pathway.
|
22025779 |
2011 |
|
Diabetes
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
In the present study, we hypothesized that melatonin attenuates renal I/R injury in diabetes by activating silent information regulator 2 associated protein 1 (SIRT1) expression and Nrf2/HO-1 signaling.
|
30578379 |
2019 |
|
Diabetes
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
In-Vitro Analysis of Glucose and Quercetin Effects on m-TOR and Nrf-2 Expression in HepG2 Cell Line (Diabetes and Cancer Connection).
|
29781726 |
2018 |
|
Diabetes
|
0.100 |
Biomarker
|
disease |
BEFREE |
We hypothesized that boosting nuclear factor erythroid-2-related factor 2 (Nrf2) antioxidant capacity with the novel Nrf2 activator dh404, would protect the retina in diabetes including vision-threatening breakdown of the blood-retinal barrier (BRB) and associated damage to macroglial Müller cells.
|
29411009 |
2018 |
|
Diabetes
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Overall, CNPs administration on the diabetic rates can attenuate detrimental effects of diabetes on the sperm potential fertility, sperm parameters, DNA integrity and Nrf2 expression levels.
|
30022501 |
2018 |
|
Diabetes
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
At the end of 3-month SFN treatment, the diabetic nephropathy, shown by renal inflammation, oxidative damage, fibrosis, and dysfunction, was significantly prevented along with an elevation of renal Nrf2 expression and transcription in diabetes/SFN group compared with diabetic group.
|
23050040 |
2012 |