|
Diabetes
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Polymorphisms in NRF2 and its target antioxidant genes: HMOX-1, NQO1, and MT, have been associated with cardiovascular diseases (CVDs) and diabetes in various ethnic groups, however, with variable results.
|
31332605 |
2020 |
|
Diabetes
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Several activators of Nrf2 are known to combat diabetes induced endothelial dysfunction and few are currently in clinical trials.
|
31838079 |
2020 |
|
Diabetes
|
0.100 |
Biomarker
|
disease |
BEFREE |
These findings support the potential of Nrf2 as a therapeutic target for the prevention and treatment of inflammation- and obesity-associated syndromes, including diabetes and atherosclerosis.
|
30913518 |
2019 |
|
Diabetes
|
0.100 |
Biomarker
|
disease |
BEFREE |
The interaction of diabetes and/or sulforaphane with contrast media on Nrf2 regulation is not yet understood.
|
31173751 |
2019 |
|
Diabetes
|
0.100 |
Biomarker
|
disease |
BEFREE |
The present review provides an overview on the role of Nrf2 in type 1 diabetes and explores if it could be a potential target for the treatment of diabetes and related complications.
|
30359563 |
2019 |
|
Diabetes
|
0.100 |
Biomarker
|
disease |
BEFREE |
Furthermore, we discuss the role of NRF2 in cancer, neurodegeneration, and diabetes as well as cardiovascular, kidney, and liver disease, with a special emphasis on NRF2-based therapeutics, including those that have made it into clinical trials.
|
30256716 |
2019 |
|
Diabetes
|
0.100 |
Biomarker
|
disease |
BEFREE |
We conclude that Nrf2 activation accelerates impaired wound healing by ameliorating diabetes-mediated oxidative stress and inflammation.
|
31616304 |
2019 |
|
Diabetes
|
0.100 |
Biomarker
|
disease |
BEFREE |
In previous studies, the widely used diabetes drug metformin has appeared to have a critical role in the regulation of Nrf2 function.
|
30803422 |
2019 |
|
Diabetes
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
In the present study, we hypothesized that melatonin attenuates renal I/R injury in diabetes by activating silent information regulator 2 associated protein 1 (SIRT1) expression and Nrf2/HO-1 signaling.
|
30578379 |
2019 |
|
Diabetes
|
0.100 |
Biomarker
|
disease |
BEFREE |
Conversely, MG scavengers (such as N-acetylcysteine, aminoguanidine or metformin) or Nrf2/Glo1 activators (such as trans-resveratrol / hesperetin) are shown to be useful in preventing MG-induced cardiovascular and renal complications in diabetes.
|
30179128 |
2018 |
|
Diabetes
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
In the experimental model of streptozotocin-induced diabetes in apolipoprotein E-deficient mice, treatment with tBHQ increased Nrf2 activity in macrophages and vascular smooth muscle cells within atherosclerotic lesions.
|
30108504 |
2018 |
|
Diabetes
|
0.100 |
Biomarker
|
disease |
BEFREE |
Therefore, C57BL/6 Nrf2 knockout (KO) and wild type (WT) mice were induced to diabetes by streptozotocin, and were treated in the presence or absence of NaB, for 20 weeks.
|
29964168 |
2018 |
|
Diabetes
|
0.100 |
Biomarker
|
disease |
BEFREE |
Because IL-1RA protects, maintains, and stimulates β-cell function in humans and Nrf-2‒Keap-1‒ARE protects β cells in animals with experimental diabetes, these actions of exenatide may contribute to a potential protective effect on β cells in diabetes.
|
29346597 |
2018 |
|
Diabetes
|
0.100 |
Biomarker
|
disease |
BEFREE |
Insulin is a potential antioxidant for diabetes-associated cognitive decline via regulating Nrf2 dependent antioxidant enzymes.
|
29793180 |
2018 |
|
Diabetes
|
0.100 |
Biomarker
|
disease |
BEFREE |
This review discusses the concept that Nrf2/HO-1 acts as a 'therapeutic funnel' through which a range of natural and synthetic anti-oxidants may drive M1 to M2 switching and improved kidney function in diabetes.
|
30014796 |
2018 |
|
Diabetes
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Since nuclear factor E2-related factor 2 (Nrf2) controls the expression of antioxidant- and detoxification genes, it is hypothesized that targeted activation of Nrf2 using phytochemicals is likely to protect pancreatic β-cells, from oxidative damage, thereby mitigates the complications of diabetes.
|
30745874 |
2018 |
|
Diabetes
|
0.100 |
Biomarker
|
disease |
BEFREE |
HDAC3 inhibition in diabetic mice may activate Nrf2 preventing diabetes-induced liver damage and FGF21 synthesis and secretion leading to aortic protection.
|
29634312 |
2018 |
|
Diabetes
|
0.100 |
Biomarker
|
disease |
BEFREE |
This study identifies Nrf2 plays a central role in skewing Th1 and Th2 dominance in the progression of diabetes.
|
29572460 |
2018 |
|
Diabetes
|
0.100 |
Biomarker
|
disease |
BEFREE |
The purpose of this study is to determine whether fenofibrate protects retinas from oxidative damage and neuroinflammation via modulating the Nrf2 pathway and blocking NLRP3 inflammasome activation during diabetes.
|
29264825 |
2018 |
|
Diabetes
|
0.100 |
Biomarker
|
disease |
BEFREE |
We also demonstrated the critical roles of the Nrf2 and NF-κB pathways in diabetes-stimulated cardiac injuries and indicated that they may be key therapeutic targets for diabetic complications.
|
28982613 |
2018 |
|
Diabetes
|
0.100 |
Biomarker
|
disease |
BEFREE |
The Kelch-like erythroid-associated protein 1 (Keap1)-NF-E2-related factor 2 (Nrf2) signaling pathway is the subject of several clinical trials evaluating the effects of Nrf2 activation on the prevention of cancer and diabetes and the treatment of chronic kidney disease and multiple sclerosis.
|
29367259 |
2018 |
|
Diabetes
|
0.100 |
Biomarker
|
disease |
BEFREE |
We have previously shown that dysfunction of the Nuclear factor (erythroid-derived 2)-like 2 (Nrf2)/ Kelch-like erythroid cell-derived protein 1 (Keap1) signaling pathway leads to extreme ROS imbalance during cutaneous wound healing in diabetes.
|
30507922 |
2018 |
|
Diabetes
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
With yearly increases in the global incidence of cardiovascular diseases (CVD) and diabetes, numerous studies have focused on characterizing whether upregulating antioxidant defenses through exogenous antioxidants (e.g. vitamin E, vitamin C) or activation of endogenous defenses (e.g. the Nuclear factor erythroid 2-related factor 2 (Nrf2) antioxidant defense pathway) may be of benefit.
|
29427794 |
2018 |
|
Diabetes
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
In-Vitro Analysis of Glucose and Quercetin Effects on m-TOR and Nrf-2 Expression in HepG2 Cell Line (Diabetes and Cancer Connection).
|
29781726 |
2018 |
|
Diabetes
|
0.100 |
Biomarker
|
disease |
BEFREE |
We hypothesized that boosting nuclear factor erythroid-2-related factor 2 (Nrf2) antioxidant capacity with the novel Nrf2 activator dh404, would protect the retina in diabetes including vision-threatening breakdown of the blood-retinal barrier (BRB) and associated damage to macroglial Müller cells.
|
29411009 |
2018 |