|
Colorectal Carcinoma
|
0.200 |
Biomarker
|
disease |
BEFREE |
Taken together, our results suggest that FoxO3 could reverse 5-FU resistance in CRC via inhibiting the Nrf2/TR1 signaling pathway, and increasing the level of intracellular reactive oxygen species.
|
31811910 |
2020 |
|
Colorectal Carcinoma
|
0.200 |
Biomarker
|
disease |
BEFREE |
This study investigates the associations between the expressions of proteins in the Nrf2/Keap1 pathway and those related to mitochondrial function and glycolysis in colorectal cancer (CRC) with or without metastasis.
|
31796664 |
2020 |
|
Colorectal Carcinoma
|
0.200 |
AlteredExpression
|
disease |
BEFREE |
Nrf2 expression was gradually increased in the apparently normal mucosa (57 ± 41)-adenoma (90 ± 36)-carcinoma (198 ± 78) direction and only showed significant higher mean of expression in CRC with brisk inflammatory peritumoral response.
|
30597358 |
2019 |
|
Colorectal Carcinoma
|
0.200 |
Biomarker
|
disease |
BEFREE |
This study highlights the STEAP1-NRF2 axis as a therapeutic target for CRC and its manipulation as a novel strategy to conquer CRC.
|
30401882 |
2019 |
|
Colorectal Carcinoma
|
0.200 |
Biomarker
|
disease |
BEFREE |
Nrf2 target genes as prognostic biomarkers in CACC remain to be explored.
|
31628914 |
2019 |
|
Colorectal Carcinoma
|
0.200 |
Biomarker
|
disease |
BEFREE |
Correction: The Nrf2 inhibitor brusatol is a potent antitumour agent in an orthotopic mouse model of colorectal cancer.
|
30774766 |
2019 |
|
Colorectal Carcinoma
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
KEAP1-NRF2 interaction analysis revealed that the rs6721961, rs35652124, rs1048290, and rs11545829 conferred the susceptibility to CRC.
|
30825237 |
2019 |
|
Colorectal Carcinoma
|
0.200 |
Biomarker
|
disease |
BEFREE |
Thus, to the best of our knowledge, our findings are the first to identify DUB3 as a NRF2 DUB and may provide a new strategy against chemotherapy resistance in CRC and other NRF2-related diseases.
|
30778200 |
2019 |
|
Colorectal Carcinoma
|
0.200 |
AlteredExpression
|
disease |
BEFREE |
Several reports indicate crosstalk between the transcription factor nuclear factor erythroid 2-related factor 2 (Nrf2) and estrogen, which has a protective effect in colorectal cancer (CRC).
|
31442293 |
2019 |
|
Colorectal Carcinoma
|
0.200 |
AlteredExpression
|
disease |
BEFREE |
Treatment of cells with 5-FU under hypoxic conditions had no effect on the expression of nuclear factor (erythroid-derived 2)-like 2 (Nrf2), a regulator of cellular resistance to oxidative stress, whereas treatment with QC alone or in combination with 5-FU reduced Nrf2 expression in all CRC cell lines tested.
|
31491980 |
2019 |
|
Colorectal Carcinoma
|
0.200 |
AlteredExpression
|
disease |
BEFREE |
Ginnalin A from Kujin tea (Acer tataricum subsp. ginnala) exhibits a colorectal cancer chemoprevention effect via activation of the Nrf2/HO-1 signaling pathway.
|
29693091 |
2018 |
|
Colorectal Carcinoma
|
0.200 |
Biomarker
|
disease |
BEFREE |
It shows an anti-carcinogenic effect in different cancers and could increase the sensitivity of cisplatin in colorectal cancer cell lines through Nrf2 pathway.
|
29808795 |
2018 |
|
Colorectal Carcinoma
|
0.200 |
Biomarker
|
disease |
BEFREE |
Nrf2 is a key factor in the reversal effect of curcumin on multidrug resistance in the HCT‑8/5‑Fu human colorectal cancer cell line.
|
30365132 |
2018 |
|
Colorectal Carcinoma
|
0.200 |
Biomarker
|
disease |
BEFREE |
Our results highlight Nrf2 as a promising drug target in the treatment of CRC.
|
29930754 |
2018 |
|
Colorectal Carcinoma
|
0.200 |
Biomarker
|
disease |
BEFREE |
EGCG increased the sensitivity of colorectal cancer cells to radiation by inhibiting cell proliferation and inducing Nrf2 nuclear translocation and autophagy.
|
30396944 |
2018 |
|
Colorectal Carcinoma
|
0.200 |
AlteredExpression
|
disease |
BEFREE |
While expression levels of Nrf2 and ABCB1 (P-gp) were markedly higher in both mRNA and protein levels in CRC biopsies (p < 0.01), Keap1 expression level was significantly lower in these samples (p < 0.05).
|
29793178 |
2018 |
|
Colorectal Carcinoma
|
0.200 |
Biomarker
|
disease |
BEFREE |
The main objective of this paper is to characterise the relationship between NRF2 and colorectal cancer by compiling data from an exhaustive literature search.
|
28542357 |
2017 |
|
Colorectal Carcinoma
|
0.200 |
Biomarker
|
disease |
BEFREE |
Sulforaphane Regulates NFE2L2/Nrf2-Dependent Xenobiotic Metabolism Phase II and Phase III Enzymes Differently in Human Colorectal Cancer and Untransformed Epithelial Colon Cells.
|
27636860 |
2017 |
|
Colorectal Carcinoma
|
0.200 |
Biomarker
|
disease |
BEFREE |
The role of Nrf2-Keap1 axis in colorectal cancer, progression, and chemoresistance.
|
28621229 |
2017 |
|
Colorectal Carcinoma
|
0.200 |
Biomarker
|
disease |
BEFREE |
However, the prognostic value of subcellular localization of Nrf2 in colorectal cancer and the underlying mechanism in tumor invasion remain unknown.
|
27033953 |
2016 |
|
Colorectal Carcinoma
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Overall, these data suggested that individuals having single-nucleotide polymorphisms in NRF2 may have a risk of colorectal cancer to some extent.
|
26899729 |
2016 |
|
Colorectal Carcinoma
|
0.200 |
Biomarker
|
disease |
BEFREE |
The mRNA level of Hmox1 in the tumor tissue of CRC is not correlated with that of the Nrf2 pathway molecules, and its ratio to the Nrf2 level may be useful for suggesting distant metastasis in CRC.
|
27999449 |
2016 |
|
Colorectal Carcinoma
|
0.200 |
Biomarker
|
disease |
BEFREE |
Dietary suppression of colorectal cancer using CA supplementation was achieved in Nrf2(+/+) but not in Nrf2(-/-) mice confirming the Nrf2 dependence of CA-induced chemopreventive effects.
|
25712056 |
2015 |
|
Colorectal Carcinoma
|
0.200 |
Biomarker
|
disease |
BEFREE |
The present study examined epigenetic changes associated with Nrf2 induction in a human CRC cell line (SNUC5) resistant to 5-FU (SNUC5/5-FUR).
|
24743738 |
2014 |
|
Colorectal Carcinoma
|
0.200 |
Biomarker
|
disease |
BEFREE |
The transcriptional factors nuclear factor-κB (NF-κB) and NF-E2-related factor 2 (Nrf2) have been recently reported to have critical roles in protecting various tissues against inflammation and colitis-associated colorectal cancer (aberrant crypt foci).
|
24901054 |
2014 |