|
Obesity
|
0.100 |
Biomarker
|
disease |
BEFREE |
Our findings suggest that obesity results in Nrf2 dysfunction which likely causes maladaptation to oxidative stress and inflammation in the RVLM.
|
31823672 |
2020 |
|
Obesity
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
CNM (1) normalized serum estradiol-17β levels, (2) induced gastric Nrf2 and phase II antioxidant enzymes through extracellular signal-regulated kinase, (ERK)/c-Jun N-terminal kinase (JNK)/p38 mitogen-activated protein kinase (MAPK), (3) reduced glucose synthase kinase 3 beta (GSK3β) and aryl hydrocarbon receptor (AhR) and this was associated with (4) increased estrogen receptor expression, BH<sub>4</sub> (Cofactor of nNOS) biosynthesis enzyme GCH-1 and nNOSα dimerization in WT Obese/T2 diabetic female mice.
|
30831189 |
2019 |
|
Obesity
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Although little information on the role of Nrf2 in the cardiovascular system is available, growing evidence indicates that decreased Nrf2 activity contributes to oxidative stress, favoring the pathophysiology of cardiovascular disorders found in obesity, diabetes mellitus, and atherosclerosis.
|
31031630 |
2019 |
|
Obesity
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Protective Effect of Lactobacillus rhamnosus GG and its Supernatant against Myocardial Dysfunction in Obese Mice Exposed to Intermittent Hypoxia is Associated with the Activation of Nrf2 Pathway.
|
31595164 |
2019 |
|
Obesity
|
0.100 |
Biomarker
|
disease |
BEFREE |
In this study, OB-IR subjects did not reflect significant differences in gene expression; however, correlations detected between sRAGE, biochemical parameters, and NRF2, besides the predominant RAGE distribution on the cell membrane in PBMC could be evidence of the early phase of the inflammatory cascade and the subsequent damage in specific tissues in subjects with OB-IR.
|
31231489 |
2019 |
|
Obesity
|
0.100 |
Biomarker
|
disease |
BEFREE |
This study focused on exploring the nuclear factor-erythroid-2-related factor (Nrf2) active compound to avoid oxidative stress related to various diseases, such as obesity and diabetes mellitus.
|
31817423 |
2019 |
|
Obesity
|
0.100 |
Biomarker
|
disease |
BEFREE |
None of these models could completely recapitulate the unexpected protection against obesity observed in the whole body Nrf2 knockout mice, but this study points out the differential roles that Nrf2 may play, beyond cytoprotection, in different target tissues and rather suggests systemic activation of the Nrf2 pathway as an effective means of prevention and treatment of obesity and type 2 diabetes.
|
29486138 |
2018 |
|
Obesity
|
0.100 |
Biomarker
|
disease |
BEFREE |
Stress-induced GCs hyper-secretion triggers glucocorticoid receptor (GR)-dependent transcriptional factor, nuclear factor kappa B (NFκB), which interferes TNFα-IL6 and keap1-Nrf2 pathways in liver regeneration and obesity through fine-tuning of TNFα, IL6 and Nrf2 signaling.
|
29566366 |
2018 |
|
Obesity
|
0.100 |
Biomarker
|
disease |
BEFREE |
Activation of NRF2 has chemopreventive effects in cancer and exerts beneficial effects in a number of diseases, including neurodegenerative diseases, inflammatory diseases, hepatosteatosis, obesity and insulin resistance.
|
30273379 |
2018 |
|
Obesity
|
0.100 |
Biomarker
|
disease |
BEFREE |
Pharmacological stimulation of Nrf2 mitigates obesity and insulin resistance in mice; however, Nrf2 activators are not clinically available due to biosafety concerns.
|
29898626 |
2018 |
|
Obesity
|
0.100 |
Biomarker
|
disease |
BEFREE |
Collectively, Nrf2 dysfunction exacerbates the deleterious effects of obesity, compromising cerebromicrovascular and brain health by impairing neurovascular coupling mechanisms, BBB integrity and synaptic function and promoting neuroinflammation.
|
29905772 |
2018 |
|
Obesity
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Thus, the use of bioactive substances such as CTP, which activates Nrf2 to reduce the cellular level of ROS and inhibit the adipogenic differentiation of hASCs, could be a new strategy for overcoming obesity.
|
30060630 |
2018 |
|
Obesity
|
0.100 |
Biomarker
|
disease |
BEFREE |
Glycyrrhizin ameliorates high fat diet-induced obesity in rats by activating NrF2 pathway.
|
29129772 |
2018 |
|
Obesity
|
0.100 |
Biomarker
|
disease |
BEFREE |
Special emphasis is placed on the effects of high fat diet (HFD) feeding on expression of nuclear-encoded mitochondrial genes (NEMGs) nuclear receptor factor 1 (NRF-1) and 2 (NRF-2) and peroxisome proliferator receptor gamma coactivator 1 alpha (PGC-1α) in the onset and progression of insulin resistance during obesity and how HFD-induced alterations in NEMG expression affect skeletal muscle mitochondrial adaptations in relation to beta oxidation of fatty acids.
|
28420087 |
2017 |
|
Obesity
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Nrf2 regulates expression of antioxidant and mitochondrial genes and has been proposed as a target for both obesity and breast cancer.
|
28277986 |
2017 |
|
Obesity
|
0.100 |
Biomarker
|
disease |
BEFREE |
Pharmacological activation of nuclear factor (erythroid-derived 2)-like 2 (Nrf2) alleviates obesity and insulin resistance in mice; however, Nrf2 inducers are not clinically available owing to safety concerns.
|
28209760 |
2017 |
|
Obesity
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The adverse impact of obesity on heart rate variability is modified by a NFE2L2 gene variant: The SAPALDIA cohort.
|
27866025 |
2017 |
|
Obesity
|
0.100 |
Biomarker
|
disease |
BEFREE |
Specific bioactive compounds in ginger and apple alleviate hyperglycemia in mice with high fat diet-induced obesity via Nrf2 mediated pathway.
|
28254022 |
2017 |
|
Obesity
|
0.100 |
Biomarker
|
disease |
BEFREE |
Our results provide a comprehensive understanding of the central role of Nrf2 in the regulation of glucose metabolism in AML12 hepatocytes, in addition to its classical roles in the regulation of redox signaling, endoplasmic reticulum stress and proinflammatory responses, and support the potential of Nrf2 as a therapeutic target for the prevention and treatment of obesity and other associated metabolic syndromes.
|
28440735 |
2017 |
|
Obesity
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Thus, the aim of this study was to explore if polymorphisms in Nrf2 and target genes are associated with diabetes and obesity in Mexican mestizo subjects.The rs1800566 of
|
27274779 |
2016 |
|
Obesity
|
0.100 |
Biomarker
|
disease |
BEFREE |
Working to understand the complex interplay among Nrf2, oxidative stress, and adipose biology could lead to a variety of possible treatments for obesity and other related disorders.
|
23319124 |
2013 |
|
Obesity
|
0.100 |
Biomarker
|
disease |
BEFREE |
NRF2 activation represents a potential novel approach in the treatment and prevention of obesity and diabetes.
|
21161163 |
2011 |
|
Obesity
|
0.100 |
Biomarker
|
disease |
BEFREE |
In the current study we show that targeted knock-out of Nrf2 in mice decreases adipose tissue mass, promotes formation of small adipocytes, and protects against weight gain and obesity otherwise induced by a high fat diet.
|
20089859 |
2010 |