|
Age related macular degeneration
|
0.100 |
Biomarker
|
disease |
BEFREE |
Then, a mouse model of dry AMD (Nrf2 wild-type (WT) and Nrf2 knockout (KO)) was established for evaluating the effects of Q-SD in vivo.
|
31781321 |
2019 |
|
Age related macular degeneration
|
0.100 |
Biomarker
|
disease |
BEFREE |
Nrf-2 (p < 0.05), HO-1 and GCLC expressions were lowered in the retina of AMD, whereas GCLM and GSTpi expressions were decreased (p < 0.05) with an increase in HO-1 in choroid-RPE of AMD.
|
31271759 |
2019 |
|
Age related macular degeneration
|
0.100 |
Biomarker
|
disease |
BEFREE |
By exposing nuclear factor erythroid 2-related factor (Nrf2) knockout (Nrf2<sup>-/-</sup>) mice to mild white light, we were able to generate a new dry-AMD like murine model to the study.
|
31601909 |
2019 |
|
Age related macular degeneration
|
0.100 |
Biomarker
|
disease |
BEFREE |
First, the nuclear factor erythroid 2-related factor 2 (NFE2L2; NRF2)-mediated OS response signalling pathway is important in the prevention of oxidative damage and a failure of this system could be critical in the development of AMD.
|
31752195 |
2019 |
|
Age related macular degeneration
|
0.100 |
Biomarker
|
disease |
BEFREE |
Consequently, these novel findings suggest that the NRF-2/PGC-1α dKO mouse is a valuable model for investigating the role of proteasomal and autophagy clearance in the RPE and in the development of dry AMD.
|
30253279 |
2019 |
|
Age related macular degeneration
|
0.100 |
Biomarker
|
disease |
BEFREE |
This review will focus on the impact of oxidative stress on the pathogenesis of age-related macular degeneration and analyze the natural and synthetic Nrf2-activating compounds that have been tested as potential therapeutic agents for the disease.
|
30455645 |
2018 |
|
Age related macular degeneration
|
0.100 |
Biomarker
|
disease |
BEFREE |
These findings indicated that Nrf2 activation could be a promising therapeutic approach for non-exudative AMD by supporting RPE maintenance.
|
30216854 |
2018 |
|
Age related macular degeneration
|
0.100 |
Biomarker
|
disease |
BEFREE |
Wingless (Wnt) and nuclear factor-erythroid 2-related factor 2 (Nrf2), two fundamental signaling systems that are vital to cell survival, decline after mice are exposed to chronic cigarette smoke and HFD, two established AMD risk factors, in a bidirectional feedback loop through phosphorylated glycogen synthase kinase 3 beta.
|
29186981 |
2018 |
|
Age related macular degeneration
|
0.100 |
Biomarker
|
disease |
BEFREE |
The underlying mechanisms may be related to the activation of the Keap1-Nrf2/HO-1 signal pathway, which may provide biological evidence to further encourage the investigation of the protective effect of Hesp in AMD disease.
|
28103505 |
2017 |
|
Age related macular degeneration
|
0.100 |
Biomarker
|
disease |
BEFREE |
Furthermore, therapeutic potential of AAV-Nrf2 in chronic disease also was tested in a light-induced mouse model of age-related macular degeneration.
|
28253482 |
2017 |
|
Age related macular degeneration
|
0.100 |
Biomarker
|
disease |
BEFREE |
In AMD specimens, Nrf2 immunolabeling was strong in the cytoplasm, with scattered nuclear labeling of macular retinal pigmented epithelial (RPE) cells that appeared normal, but was decreased and without nuclear labeling in dysmorphic cells overlying drusen, a hallmark AMD lesion.
|
24440594 |
2014 |