Carcinogenesis
|
0.400 |
Biomarker
|
phenotype |
BEFREE |
Diethylnitrosamine and thioacetamide-induced hepatic damage and early carcinogenesis in rats: Role of Nrf2 activator dimethyl fumarate and NLRP3 inhibitor glibenclamide.
|
31761320 |
2020 |
Carcinogenesis
|
0.400 |
Biomarker
|
phenotype |
BEFREE |
The Keap1-Nrf2 axis has a fundamental role in carcinogenesis.
|
30803422 |
2019 |
Carcinogenesis
|
0.400 |
Biomarker
|
phenotype |
BEFREE |
Ingenuity Pathways Analysis (IPA) identified many cancer related pathways including PTEN, p53, Nrf2 and inflammatory signaling in UVB-irradiation induced carcinogenesis.
|
30771437 |
2019 |
Carcinogenesis
|
0.400 |
Biomarker
|
phenotype |
BEFREE |
Based on the recently described crosstalk between TGF-β1 and Nrf2 in the PDAC development, the involvement of ATF3 and its splice variant ΔZip2 in TGF-β1- and Nrf2-driven pancreatic tumorigenesis was investigated.
|
30302023 |
2019 |
Carcinogenesis
|
0.400 |
Biomarker
|
phenotype |
BEFREE |
Overall, our findings place Nrf2 and p62 as the key components of the mesenchymal subtype network, with implications to tumorigenesis and treatment resistance.
|
31444413 |
2019 |
Carcinogenesis
|
0.400 |
Biomarker
|
phenotype |
BEFREE |
aPKCι promotes gallbladder cancer tumorigenesis and gemcitabine resistance by competing with Nrf2 for binding to Keap1.
|
30822690 |
2019 |
Carcinogenesis
|
0.400 |
Biomarker
|
phenotype |
BEFREE |
Moreover, long-term consumption of cholesterol-rich diet activated nuclear factor-kappa B (NF-κB) and p62/sequestosome 1 (Sqstm1)-nuclear factor erythroid 2 (NRF2) axis, enhanced fibrogenesis, and consequently accelerated hepatic tumorigenesis.
|
31004178 |
2019 |
Carcinogenesis
|
0.400 |
Biomarker
|
phenotype |
BEFREE |
Although it plays a protective role against tumorigenesis, emerging evidence has shown that the NRF2 pathway is frequently altered in different types of cancer, including lung cancer.
|
31574294 |
2019 |
Carcinogenesis
|
0.400 |
AlteredExpression
|
phenotype |
BEFREE |
NRF1 and NRF2 mRNA and Protein Expression Decrease Early during Melanoma Carcinogenesis: An Insight into Survival and MicroRNAs.
|
31687076 |
2019 |
Carcinogenesis
|
0.400 |
Biomarker
|
phenotype |
BEFREE |
However, the mechanisms of how persistent NFE2L2 activation induces liver injury and tumorigenesis are unknown.
|
31216956 |
2019 |
Carcinogenesis
|
0.400 |
Biomarker
|
phenotype |
BEFREE |
RPB5-mediating protein promotes cholangiocarcinoma tumorigenesis and drug resistance by competing with NRF2 for KEAP1 binding.
|
31541481 |
2019 |
Carcinogenesis
|
0.400 |
Biomarker
|
phenotype |
BEFREE |
Nuclear factor erythroid 2-related factor 2 (Nrf2), a master regulator of many cytoprotective genes, plays a protective role in carcinogenesis.
|
31628914 |
2019 |
Carcinogenesis
|
0.400 |
Biomarker
|
phenotype |
BEFREE |
This may indicate a possible role of Nrf2 in CRC carcinogenesis and a role of Bach1 in CRC progression.
|
30597358 |
2019 |
Carcinogenesis
|
0.400 |
Biomarker
|
phenotype |
BEFREE |
Collectively, our results indicate the presence of a novel NRF2 SUMOylation-mediated signaling process that maintains HCC tumorigenesis in normal conditions and in response to metabolic stress.
|
31546024 |
2019 |
Carcinogenesis
|
0.400 |
Biomarker
|
phenotype |
BEFREE |
Kelch-like ECH-associated protein 1 (KEAP1), as a negative regulator of nuclear factor erythroid 2 like 2 ( NRF2), plays a pivotal role in NRF2 signaling pathway and involves in tumorigenesis.
|
30825237 |
2019 |
Carcinogenesis
|
0.400 |
Biomarker
|
phenotype |
BEFREE |
We found that NQO1 is not essential for the beneficial effects of CR on glucose homeostasis, physical performance, metabolic flexibility, life-span extension, and (unlike our previously observation with Nrf2) chemical-induced tumorigenesis.
|
29733330 |
2019 |
Carcinogenesis
|
0.400 |
Biomarker
|
phenotype |
BEFREE |
More importantly, Nrf2 is proved to contribute to the chemoresistance and radioresistance of cancer cells as well as inflammation-induced carcinogenesis.
|
30929309 |
2019 |
Carcinogenesis
|
0.400 |
AlteredExpression
|
phenotype |
BEFREE |
Our data indicate that accumulation of p62 by impaired autophagic flux is involved in the activation of NRF2 and contributes to skin tumorigenesis due to chronic arsenite exposure.
|
31781319 |
2019 |
Carcinogenesis
|
0.400 |
GeneticVariation
|
phenotype |
BEFREE |
Several natural-product Nrf2 activators have been developed to prevent pancreatic carcinogenesis, while the Nrf2 inhibitors have been examined for their efficacy in inhibiting PC growth and metastasis and reversing chemoresistance.
|
31511020 |
2019 |
Carcinogenesis
|
0.400 |
Biomarker
|
phenotype |
BEFREE |
Taken together, the Nrf2-HO-1 axis is considered to play a role in cellular adaptive survival response to H. pylori-induced gactric carcinogenesis by inducing autophagy.
|
30731075 |
2019 |
Carcinogenesis
|
0.400 |
AlteredExpression
|
phenotype |
BEFREE |
It has been reported that activation of NF-E2 p45-related factor-2 (NRF2), a transcription factor, induces a variety of antioxidant enzymes, and plays an important role in preventing carcinogenesis.
|
31777421 |
2019 |
Carcinogenesis
|
0.400 |
Biomarker
|
phenotype |
BEFREE |
Mutations that disrupt the interaction between NRF2 and KEAP1, an inhibitor of NRF2, lead to NRF2 hyperactivation and promote oncogenesis.
|
30195190 |
2018 |
Carcinogenesis
|
0.400 |
Biomarker
|
phenotype |
CTD_human |
The carcinogenesis of prostate cancer (PCa) in TRAMP model is highly correlated with hypermethylation in the promoter region of Nrf2 and the accompanying reduced transcription of Nrf2 and its regulated detoxifying genes.
|
29228771 |
2018 |
Carcinogenesis
|
0.400 |
Biomarker
|
phenotype |
BEFREE |
In this review, we discuss major groups of phytochemicals and their regulation on cell signaling transduction against carcinogenesis via key participators, such as Nrf2, CYP450, MAPK, Akt, JAK/STAT, Wnt/β-catenin, p53, NF-κB, and cancer-related miRNAs.
|
29498272 |
2018 |
Carcinogenesis
|
0.400 |
PosttranslationalModification
|
phenotype |
BEFREE |
The carcinogenesis of prostate cancer (PCa) in TRAMP model is highly correlated with hypermethylation in the promoter region of Nrf2 and the accompanying reduced transcription of Nrf2 and its regulated detoxifying genes.
|
29228771 |
2018 |