NFE2L2, nuclear factor, erythroid 2 like 2, 4780

N. diseases: 823; N. variants: 34
Disease: Mammary Neoplasms ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C1458155
Disease: Mammary Neoplasms
Mammary Neoplasms 		0.060 Biomarker group BEFREE In line with these, CD44 significantly colocalized with NRF2 in breast tumor clinical samples. 29729523 2018
CUI: C1458155
Disease: Mammary Neoplasms
Mammary Neoplasms 		0.060 PosttranslationalModification group BEFREE Downregulation of Nrf2 and MZF-1 and hypermethylation of the FPN promoter were concurrently associated with decreased FPN concentration in breast tumors. 25451081 2015
CUI: C1458155
Disease: Mammary Neoplasms
Mammary Neoplasms 		0.060 AlteredExpression group BEFREE Blocking LPA production with 10 mg/kg per d ONO-8430506 (competitive autotaxin inhibitor, IC90 = 100 nM) decreased expression of Nrf2, multidrug-resistant transporters, and antioxidant genes in breast tumors by ≤90%. 25398768 2015
CUI: C1458155
Disease: Mammary Neoplasms
Mammary Neoplasms 		0.060 Biomarker group LHGDN Resveratrol prevents estrogen-DNA adduct formation and neoplastic transformation in MCF-10F cells. 19138946 2008
CUI: C1458155
Disease: Mammary Neoplasms
Mammary Neoplasms 		0.060 Biomarker group LHGDN The nuclear matrix protein, NRP/B, enhances Nrf2-mediated oxidative stress responses in breast cancer cells. 17875699 2007
CUI: C1458155
Disease: Mammary Neoplasms
Mammary Neoplasms 		0.060 GeneticVariation group LHGDN Genetic variability in iron-related oxidative stress pathways (Nrf2, NQ01, NOS3, and HO-1), iron intake, and risk of postmenopausal breast cancer. 17726138 2007