|
Psoriasis
|
0.180 |
AlteredExpression
|
disease |
BEFREE |
The decreased expression of the DEGs was accompanied by the downregulation of STAT1, EHF, FOSL1, STAT3, and NFKB1 and the upregulation of FOXC1 upon blocking interleukin 17 (IL-17) or tumor necrosis factor α signaling in psoriasis.
|
30825251 |
2019 |
|
Psoriasis
|
0.180 |
Biomarker
|
disease |
BEFREE |
The imiquimod-induced psoriasis mouse model was employed to examine the role of NFKB1 in psoriasis via the assessment of psoriasis area and severity index (PASI), including erythema, thickness and scales.
|
29748001 |
2018 |
|
Psoriasis
|
0.180 |
GeneticVariation
|
disease |
GWASCAT |
Analysis of five chronic inflammatory diseases identifies 27 new associations and highlights disease-specific patterns at shared loci.
|
26974007 |
2016 |
|
Psoriasis
|
0.180 |
Biomarker
|
disease |
BEFREE |
Rs1020760 was preferentially associated with family history of psoriasis, implying that NFKB1 might not only play important roles in the development of psoriasis, but might also contribute to the special phenotypes of this disease.
|
27346731 |
2016 |
|
Psoriasis
|
0.180 |
GeneticVariation
|
disease |
BEFREE |
We confirmed four known psoriasis susceptibility loci (IL12B, IFIH1, ERAP1 and RNF114; 2.30 × 10(-20)≤P≤2.41 × 10(-7)) and identified three new susceptibility loci: 4q24 (NFKB1) at rs1020760 (P=2.19 × 10(-8)), 12p13.3 (CD27-LAG3) at rs758739 (P=4.08 × 10(-8)) and 17q12 (IKZF3) at rs10852936 (P=1.96 × 10(-8)).
|
25006012 |
2014 |
|
Psoriasis
|
0.180 |
Biomarker
|
disease |
BEFREE |
In addition, the regulation network between transcription factors and pathways revealed that NF-κB1 could promote the Toll-like receptor signaling pathway and that SP3 may inhibit the steroid hormone biosynthesis pathway in psoriasis.
|
23078099 |
2013 |
|
Psoriasis
|
0.180 |
GeneticVariation
|
disease |
LHGDN |
Genome-wide scan reveals association of psoriasis with IL-23 and NF-kappaB pathways.
|
19169254 |
2009 |
|
Psoriasis
|
0.180 |
Biomarker
|
disease |
BEFREE |
Our study supported the involvement of six candidate genes in susceptibility to psoriasis: SCL12A8, which belongs to the solute carrier gene family; FLG and TGM5, which are involved in epidermal differentiation; CARD15 and CYLD, which modulate the transcription factor NF-kB; and IL1RN, which encodes an IL receptor antagonist.
|
19554025 |
2009 |
|
Psoriasis
|
0.180 |
GeneticVariation
|
disease |
LHGDN |
Compared with the DD genotype, a significantly increased psoriasis risk was associated with the NFKB1 WW genotype (adjusted OR = 1.57, 95% CI = 1.10-2.24).
|
18330586 |
2008 |
|
Psoriasis
|
0.180 |
GeneticVariation
|
disease |
BEFREE |
Compared with the DD genotype, a significantly increased psoriasis risk was associated with the NFKB1 WW genotype (adjusted OR = 1.57, 95% CI = 1.10-2.24).
|
18330586 |
2008 |