|
Asthma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Enzyme-linked immunosorbent assay (ELISA) was used to measure the levels of immunoglobulin E (IgE), interleukin-5 (IL-5), nerve growth factor (NGF) and interferon-γ (IFN-γ) in asthma allergy.
|
30359762 |
2019 |
|
Asthma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
SAD could improve pulmonary functions, relieve lung injury, as well as reduce IL-13, PGD<sub>2</sub> and NGF levels of OVA plus PM2.5 aggravated asthma model in mice.
|
30836174 |
2019 |
|
Asthma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Notably, compared with the asthma model group, immunohistochemical results revealed that LSPF treatment suppressed OVA induced inflammatory reactions (P<0.05) and NGF (P<0.05) and TrkA expression levels (P<0.05).
|
29568869 |
2018 |
|
Asthma
|
0.100 |
Biomarker
|
disease |
BEFREE |
NGF participates in the pathogenesis of asthma in mice.
|
29611766 |
2018 |
|
Asthma
|
0.100 |
Biomarker
|
disease |
BEFREE |
12 mice in each group were injected with lentiviral vectors expressing non-targeting shRNA (sham shRNA), targeting NGF (shRNA-1 and shRNA-2), or normal saline for control before the asthma models were established.
|
29757584 |
2018 |
|
Asthma
|
0.100 |
Biomarker
|
disease |
BEFREE |
The modulation of p75NTR on pDCs significantly influences disease progression of asthma in an ovalbumin-induced mouse model mediated by the TLR9 signaling pathway. p75NTR activation of pDCs from patients with asthma increased allergen-specific T cell proliferation and cytokine secretion in nerve growth factor concentration-dependent manner.
|
28861085 |
2017 |
|
Asthma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Our results suggest that, among analysed neurotrophins, NGF serum levels may be influenced by the genotype of NTRK1 gene individually as well as in the interaction with NGF functional genetic variant suggesting their involvement in allergic inflammation in asthma.
|
23195334 |
2013 |
|
Asthma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
In addition, gene-gene interaction analysis revealed a significant epistatic interaction between MAPK (rs889312) and NGF (rs11102930) variants in asthma susceptibility.
|
22468730 |
2012 |
|
Asthma
|
0.100 |
Biomarker
|
disease |
BEFREE |
These results suggest that Kidins220/ARMS partly participates in the pathogenesis of asthma through the NGF-TrkA signaling pathway, possibly representing a new mechanism in asthma.
|
20934630 |
2010 |
|
Asthma
|
0.100 |
Biomarker
|
disease |
LHGDN |
The neurotrophins nerve growth factor, brain-derived neurotrophic factor, neurotrophin-3, and neurotrophin-4 are survival and activation factors for eosinophils in patients with allergic bronchial asthma.
|
12900521 |
2003 |