|
Schizophrenia
|
0.200 |
GeneticVariation
|
disease |
GWASCAT |
Genome-Wide Association Study Detected Novel Susceptibility Genes for Schizophrenia and Shared Trans-Populations/Diseases Genetic Effect.
|
30285260 |
2019 |
|
Schizophrenia
|
0.200 |
Biomarker
|
disease |
BEFREE |
Neurotrophic factors like Brain-Derived Neurotrophic Factor (BDNF), Neurotrophin 3 (NT3) and Nerve Growth Factor (NGF), play a role in neuroplasticity and neurogenesis contributing to the pathogenesis of schizophrenia.
|
30782512 |
2019 |
|
Schizophrenia
|
0.200 |
AlteredExpression
|
disease |
BEFREE |
These results suggest an increased vulnerability of schizophrenia patients to changes in NGF levels compared to healthy controls and support a role for NGF signaling in the pathophysiology of schizophrenia.
|
31105606 |
2019 |
|
Schizophrenia
|
0.200 |
Biomarker
|
disease |
BEFREE |
In the pursuit of further establishing a neurodevelopmental animal model to investigate the mechanisms underlying impaired executive function, a core and severely debilitating symptom of schizophrenia, we sought to characterize the deficits in behavioral flexibility in adult rats following neonatal infusions of nerve growth factor (NGF) into the medial part of the developing frontal cortex.
|
29165654 |
2018 |
|
Schizophrenia
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Using a random effects model, we confirmed that decreased levels of neurotrophins (BDNF, NGF and NT-4/5) were associated with schizophrenia (Hedges's g = -0.846; SE = 0.058; 95% confidence interval: -0.960 to -0.733; Z-value = -14.632; p-value = 0.000).
|
30269004 |
2018 |
|
Schizophrenia
|
0.200 |
Biomarker
|
disease |
BEFREE |
This study aimed to explore the relationship between serum nerve growth factor beta (NGF-beta), brain-derived neurotrophic factor (BDNF), and glial-derived neurotrophic factor (GDNF) levels and psychopathology in unmedicated patients with schizophrenia.
|
29366645 |
2018 |
|
Schizophrenia
|
0.200 |
AlteredExpression
|
disease |
BEFREE |
Our data demonstrates that Ket induced the model of SZ by altering the behavioural parameters (e.g. hyperlocomotion, social impairment, deficits in the sensory-motor profile and memory damage in the adult animals); and also caused changes in the parameters of oxidative stress (lipid hydroperoxide - LPO; 8-isoprostane - 8-ISO; 4-hydroxynonenal - 4-HNE; protein carbonyl content; superoxide dismutase - SOD and catalase - CAT) as well as in the levels of neurotrophic factors (brain-derived neurotrophic factor - BDNF and nerve growth factor - NGF) particularly within the FC of adult offspring.
|
29782958 |
2018 |
|
Schizophrenia
|
0.200 |
Biomarker
|
disease |
BEFREE |
Preclinical and clinical studies suggest that brain-derived neurotrophic factor and nerve growth factor are involved in the pathogenesis of schizophrenia (SCZ).
|
30172685 |
2018 |
|
Schizophrenia
|
0.200 |
Biomarker
|
disease |
BEFREE |
Random-effects meta-analysis showed that SCZ (Z = 2.14, P = 0.033, SMD = -1.08, 95% CI = -2.07 to -0.09) and MDD (Z = 2.57, P = 0.010, SMD = -0.61, 95% CI = -1.08 to -0.14) patients had significantly reduced NGF levels, compared with healthy controls.
|
27898323 |
2017 |
|
Schizophrenia
|
0.200 |
AlteredExpression
|
disease |
BEFREE |
Subgroup analyses revealed reduced NGF levels both in serum (Hedges's g=-0.671, 95% CI=-1.259 to -0.084, P=0.025) and plasma (Hedges's g=-0.621, 95% CI=-0.980 to -0.261, P<0.001) of the patients, and in drug-free (Hedges's g=-0.670, 95% CI=-1.118 to -0.222, P=0.003) and medicated (Hedges's g=-0.357, 95% CI=-0.592 to -0.123, P=0.003) patients with SCZ.
|
28070123 |
2017 |
|
Schizophrenia
|
0.200 |
AlteredExpression
|
disease |
BEFREE |
Since NGF and BDNF may also be changed in the CNS of animal models of schizophrenia, we investigated whether treatment with antipsychotic drugs (haloperidol, risperidone, and olanzapine) affects the constitutive levels of NGF and BDNF in the CNS.
|
14699963 |
2004 |
|
Schizophrenia
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
This method was then used to examine the coding region of the beta-nerve growth factor (NGF) gene for polymorphisms in PCR-generated DNA fragments derived from lymphocyte DNA of subjects with schizophrenia and normal subjects.
|
7786881 |
1995 |