NGF, nerve growth factor, 4803

N. diseases: 616; N. variants: 11
Disease: Ganglioneuroblastoma ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0206718
Disease: Ganglioneuroblastoma
Ganglioneuroblastoma 		0.010 Biomarker disease BEFREE Genes selectively expressed in mature neurons (SCG-10, ret proto-oncogene, GAP-43, etc.) are transcriptionally activated, and neurite outgrowth further demonstrates differentiation of transfectants following NGF stimulation. trkA-expressing NB cells remain tumorigenic in nude mice; however, subcutaneous treatment of tumor-bearing mice with NGF induces Schwannian and neuronal cell differentiation similar to the induction seen in human ganglioneuroblastomas. 8246962 1993