Squamous cell carcinoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Coimmunoprecipitation and confocal microscopy studies using SCC9-P and various epithelial cell lines with endogenous plakoglobin expression revealed that Nm23 interacts with plakoglobin, cadherins and alpha-catenin.
|
20101217 |
2010 |
Squamous cell carcinoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
There was no statistically significant trend in tumour staining from keratoacanthoma through decreasing grades of differentiation of squamous cell carcinoma. nm23 product expression does not appear to correlate with differentiation, itself an indicator of metastatic potential, in this system of human squamous cell neoplasms.(ABSTRACT TRUNCATED AT 250 WORDS)
|
8358113 |
1993 |
Squamous cell carcinoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Furthermore in stage I and II, poorly differentiated squamous cell carcinomas contained significantly more nm23 mRNA than did moderately differentiated ones (p < 0.027).
|
7863493 |
1994 |
Squamous cell carcinoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
The metastasis suppressor activity of nm23/nucleoside diphosphate (NDP) kinase was assessed using human oral squamous cell carcinoma (SCC) cell lines.
|
10632374 |
1999 |
Squamous cell carcinoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
A linear decrease (p = 0.001) was observed in nm23-H1 expression, starting from CIN1 (85% with normal expression), with the most dramatic down regulation on transition from CIN2 (70% normal) to CIN3 (39%) and further to SCC (25%).
|
16537673 |
2006 |
Squamous cell carcinoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
In addition, our results further indicated cigarette smoking could aggravate the extent of nm23-H1 expression and possibly disease progression of OSCC patients.
|
15150613 |
2004 |
Squamous cell carcinoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
NM-23 gene loss of heterozygosity and protein expression in high-stage laryngeal squamous cell carcinomas.
|
16531762 |
2006 |
Squamous cell carcinoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Frequent loss of heterozygosity for Rb, TP53, and chromosome arm 3p, but not NME1 in squamous cell carcinomas of the supraglottic larynx.
|
8174043 |
1994 |
Squamous cell carcinoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
The increases in nm23 mRNA expression were stronger in advanced stages of squamous-cell carcinoma, large-cell carcinoma, sarcoma and carcinoids than in early stages of the respective tumor types.
|
8375920 |
1993 |
Squamous cell carcinoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Thus we have a strong hint that the nm23 protein is secreted by the bronchogenic squamous cell carcinoma.
|
9080143 |
1997 |
Squamous cell carcinoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Overexpression of nucleoside diphosphate/kinase A/nm23-H1 protein in human lung tumors: association with tumor progression in squamous carcinoma.
|
8569178 |
1996 |
Squamous cell carcinoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
These findings suggest that nm23-H1 inhibits the invasive activity of oral squamous cell carcinoma by suppression of cell motility without altering the MMP-2 and MMP-9 status.
|
11337376 |
2001 |
Squamous cell carcinoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
The NM23 gene and its expression in oral squamous cell carcinoma.
|
10373649 |
1999 |
Squamous cell carcinoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
This pilot study examines the expression of the nm23 gene product compared with nodal status in 70 consecutive patients with squamous cell carcinomas of the head and neck.
|
10629490 |
2000 |
Squamous cell carcinoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
We found normal cervix and CIN 1 samples had concurrent low expression of hTERT and nm23-H1, whereas high-grade CIN and SCC samples had concurrent high immunoreactivities.
|
17359290 |
2007 |