|
melanoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
The nm23 gene is a potential metastasis-suppressor gene originally identified in a murine melanoma line.
|
8102131 |
1993 |
|
melanoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
There was no inverse correlation between the nm23 protein and melanoma metastasis which suggested that the nm23 protein does not appear to be lost during melanoma metastasis.
|
8971556 |
1996 |
|
melanoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Individual cells within melanoma sphere cultures displayed a wide range of NME1 expression across multiple melanoma cell lines.
|
31123173 |
2019 |
|
melanoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Several studies on human breast, hepatocellular, gastric, ovarian, and colon carcinomas and melanomas have shown that reduced nm23-H1 expression was closely related to metastatic progression with poor prognosis.
|
11337376 |
2001 |
|
melanoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Some experimental studies demonstrated a significantly low metastatic potential of melanoma cell lines transfected with the nm23 gene.
|
9824622 |
1998 |
|
melanoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
From a series of tumor cohort studies, low expression of Nm23/NDP kinase has been correlated with poor patient prognosis and survival, lymph node infiltration, and histopathological indicators of high metastatic potential in a number of cancer types, including mammary and ovarian carcinomas and melanoma.
|
11768314 |
2000 |
|
melanoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
These studies demonstrate for the first time in vivo a potent metastasis suppressor activity of NM23 in UVR-induced melanoma, and have provided new tools for identifying molecular mechanisms that underlie melanoma metastasis.
|
22699362 |
2013 |
|
melanoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Importantly, the invasion- and metastasis-promoting activity of c-Abl/Arg is dependent on their ability to induce NM23-H1 degradation, and the pathway is clinically relevant as c-Abl/Arg activity and NM23-H1 expression are inversely correlated in primary breast cancers and melanomas.
|
24096484 |
2014 |
|
melanoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Two isotypes of murine nm23/nucleoside diphosphate kinase, nm23-M1 and nm23-M2, are involved in metastatic suppression of a murine melanoma line.
|
7728768 |
1995 |
|
melanoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Nm23-H1 gene expression is inversely correlated with tumor metastatic potential in certain tumors, including melanomas, breast carcinomas, and hepatocellular carcinomas.
|
8270257 |
1994 |
|
melanoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
In melanomas, no direct correlation between the metastatic phenotype and nm23 expression could be detected.
|
9085150 |
1997 |
|
melanoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
An acid-stable (nonhistidine) phosphorylation was identified on autophosphorylated purified recombinant Nm23 proteins and [32P]orthophosphate-labeled human breast carcinoma and murine melanoma Nm23.
|
8245015 |
1993 |
|
melanoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
A strong association has been observed between reduced expression of Nm23 gene and acquisition of metastatic behaviour in some tumour cells including breast cancer and melanoma, but not in others such as colon cancer, neuroblastoma, and cervical cancer.
|
8394105 |
1993 |
|
melanoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Expression of NME1 strongly suppressed cell motility in melanoma cell lines 1205LU and M14.
|
25808322 |
2015 |
|
melanoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
In addition, a number of the NME1-regulated genes were shown to be of prognostic value for distant disease-free survival and overall survival in melanoma and breast cancer.
|
25048347 |
2015 |
|
melanoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
To determine whether metastasis-related functions of NDPKs are mediated by their catalytic activity in membrane bound or soluble complexes, we have stably transfected highly metastatic human melanoma Line IV Cl 1 cells with wild-type and catalytically inactive (H118Y) nm23-H1 and nm23-H2 genes and assayed their metastatic potential in nude mice.
|
11058869 |
2000 |
|
melanoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
The nm23-H1 gene, localized to chromosome 17q21-22, has been demonstrated in transfection experiments to significantly inhibit the metastatic potential of melanoma and breast carcinoma cell lines.
|
8854401 |
1996 |
|
melanoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Identification of a gene expression signature associated with the metastasis suppressor function of NME1: prognostic value in human melanoma.
|
29058705 |
2018 |
|
melanoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Although forced expression of NM23-H1 potently suppressed spontaneous lung metastasis of subcutaneous tumor explants derived from the human melanoma cell line 1205LU, no significant metastasis suppressor activity was obtained with the exonuclease-deficient variants E(5) A and K(12) Q.
|
20209495 |
2011 |
|
melanoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
This report outlines recent findings from our laboratory indicating that the metastasis suppressor function of NM23-H1 in human melanoma involves a spectrum of molecular mechanisms.
|
21448569 |
2011 |
|
melanoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
The expression of nm23 mRNA and nm23 antigen in human uveal melanomas is correlated closely with reduced metastatic behavior in experimental animals and may serve as a sensitive prognostic indicator of malignancy and survival in patients with uveal melanomas.
|
8843913 |
1996 |
|
melanoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The putative metastasis suppressor genes, NME1(nm23-1) and NME2(nm23-2), were examined in a model system we developed to approximate the dissemination of melanoma from a primary skin tumor.
|
7794272 |
1995 |
|
melanoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Of the genes identified, seven genes: galectin 3 (Lgals3), melanoma cell adhesion molecule (Mcam), fibronectin 1 (Fn1), signal transducer and activator of transcription 3 (Stat3), microphthalmia-associated transcription factor (Mitf), max interacting protein 1 (Max1), and non-metastatic cells 1, protein (NM23A) expressed in (Nme1) are known to be associated with melanoma, but have not yet been reported as being regulated by hypoxia in human melanoma cells.
|
21912348 |
2011 |
|
melanoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
In addition, analysis of nm23 gene expression on bioptic tissue may represent an extreme useful prognostic tool for metastatic progression of uveal melanomas.
|
9195562 |
1997 |
|
melanoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Much of the attention has been focused on the metastasis-suppressing role of NDPK-A in human tumors, including breast carcinoma and melanoma.
|
28991262 |
2018 |