|
Secondary Neoplasm
|
0.100 |
GeneticVariation
|
group |
BEFREE |
We report the first correlation of Nm23 sequence and its tumor metastasis-suppressive capacity using site-directed mutagenesis and an in vitro tumor cell motility assay.
|
8810265 |
1996 |
|
Secondary Neoplasm
|
0.100 |
GeneticVariation
|
group |
BEFREE |
This overexpression was lost, however, in some advanced cases: 89% and 81% of TNM (tumour, node, metastases) stages 0-II showed Nm23-H1 and -H2 overexpression, respectively, which significantly differed from 47% and 38% of stage III-IV tumours.
|
8549951 |
1995 |
|
Secondary Neoplasm
|
0.100 |
AlteredExpression
|
group |
BEFREE |
It was found that patients developing metastases during the first 2 years after diagnosis had significantly lower levels of tumor nm23 expression (56% of the mean value) compared to patients with less aggressive disease (164%) (P < 0.0004).
|
1356624 |
1992 |
|
Secondary Neoplasm
|
0.100 |
Biomarker
|
group |
BEFREE |
The nm23 gene has been proposed as a candidate tumor metastasis suppressor in some human cancers.
|
9663428 |
1998 |
|
Secondary Neoplasm
|
0.100 |
Biomarker
|
group |
BEFREE |
To analyze the prognostic significance of the genes casein kinase 2 alpha subunit (CSNK2A1), anti-apoptosis clone-11 (AAC-11), and tumor metastasis suppressor NME1 in completely resected non-small cell lung cancer (NSCLC) patients.
|
20671611 |
2010 |
|
Secondary Neoplasm
|
0.100 |
Biomarker
|
group |
BEFREE |
Loss of NM-23, a reported tumor metastasis suppressor gene, was found only in leiomyosarcomas (5 of 9, or 56%), and 4 of 5 (80%) of these were the only cases that demonstrated distant metastases (P = 0.04).
|
16330948 |
2006 |
|
Secondary Neoplasm
|
0.100 |
AlteredExpression
|
group |
BEFREE |
There was a strong inverse correlation between the levels of nm23 mRNA expression and nm23 antigen expression and the development of metastases of all seven human uveal melanomas and both murine skin melanomas transplanted intracamerally.
|
8843913 |
1996 |
|
Secondary Neoplasm
|
0.100 |
Biomarker
|
group |
BEFREE |
In sharp contrast, the low frequency of loss at NME1 and its equal distribution in nodal metastasis-positive and -negative patients suggests that inactivation of this gene by allelic loss probably does not play a role in the development of regional metastases from these tumors.
|
8174043 |
1994 |
|
Secondary Neoplasm
|
0.100 |
Biomarker
|
group |
BEFREE |
Nm23-H1 is a well-known tumor metastasis suppressor, which functions as a nucleoside-diphosphate kinase converting nucleoside diphosphates to nucleoside triphosphates with an expense of ATP.
|
20448457 |
2010 |
|
Secondary Neoplasm
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Short term (median follow-up of 16 months) clinical course data were consistent with nm23 RNA levels, in that 2 of 11 low nm23 RNA content patients (including one from the 0 involved lymph node group) developed metastases, while none of the high nm23 RNA patients have experienced recurrent disease.
|
2475243 |
1989 |
|
Secondary Neoplasm
|
0.100 |
Biomarker
|
group |
BEFREE |
These results demonstrated that nm23-H1 can suppress the mobility and metastatic capacity of cancer cells and the molecular mechanism by which nm23-H1 suppresses tumor metastasis may be via increasing the expression of metastasis-related genes such as beta-Catenin, E-Cadherin and TIMP-1 and decreasing the expression of MMP-2, CD44V6 and VEGF.
|
17167724 |
2006 |
|
Secondary Neoplasm
|
0.100 |
Biomarker
|
group |
BEFREE |
NME1 is a wide-spectrum tumor metastasis suppressor gene that plays an important role in suppressing the invasion and metastasis of tumor cells.
|
23856325 |
2013 |
|
Secondary Neoplasm
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Therefore, in the colon, tissue-specific events dissociate nm23 expression from loss of tumor metastatic competence.
|
2023273 |
1991 |
|
Secondary Neoplasm
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Low nm23 expression is predictive of distal metastases and appears to be a risk factor that is independent of the presence or absence of positive axillary nodes at diagnosis.
|
11179491 |
2001 |
|
Secondary Neoplasm
|
0.100 |
GeneticVariation
|
group |
BEFREE |
The expression of the nm23-H1 gene has been suggested to have an inverse association with metastases in certain tumours.
|
8735718 |
1996 |
|
Secondary Neoplasm
|
0.100 |
Biomarker
|
group |
BEFREE |
One gene postulated to play a role in tumour metastasis suppression is NME1 (nm23-H1), and an inverse relationship between NME1 expression and metastatic potential has been observed for some solid tumours.
|
7622307 |
1995 |
|
Secondary Neoplasm
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Our data suggest that by increasing the expression and stability of Nm23, plakoglobin has a role in regulating the metastasis suppressor activity of Nm23, which may further provide a potential mechanism for the tumor/metastasis suppressor function of plakoglobin itself.
|
20101217 |
2010 |
|
Secondary Neoplasm
|
0.100 |
AlteredExpression
|
group |
BEFREE |
nm23 was originally identified as an antimetastatic gene, the expression of which was inversely correlated with tumor metastatic potential in rodent model systems.
|
7530600 |
1995 |
|
Secondary Neoplasm
|
0.100 |
Biomarker
|
group |
BEFREE |
The human nm23-H1 was discovered as a tumor metastasis suppressor based on its reduced expression in melanoma cell lines with low versus high metastatic potential.
|
16739125 |
2006 |
|
Secondary Neoplasm
|
0.100 |
Biomarker
|
group |
BEFREE |
The present results indicated that Ser44 and Ser120 sites of Nm23-H1 may be responsible for its biological suppressive effects of STAT3 and tumor metastasis, which may contribute to illuminate the metastasis suppression function of Nm23-H1 in lung cancer.
|
28781685 |
2017 |
|
Secondary Neoplasm
|
0.100 |
AlteredExpression
|
group |
BEFREE |
None of the patients with a higher nm23-H1 protein level had detectable distant metastases at the end of this study (chi 2 test, p < 0.05).
|
8893591 |
1996 |
|
Secondary Neoplasm
|
0.100 |
Biomarker
|
group |
BEFREE |
This interaction may play important roles in the effects of Rad on glucose metabolism and the effects of nm23 on tumor metastasis and developmental regulation.
|
10611312 |
1999 |
|
Secondary Neoplasm
|
0.100 |
Biomarker
|
group |
BEFREE |
Finally, nm-23-H1 immunoreactivity was more specific but less sensitive than AMES score to predict metastases.
|
11502841 |
2001 |
|
Secondary Neoplasm
|
0.100 |
Biomarker
|
group |
BEFREE |
NM23 is a multifunctional gene, which inhibits tumor metastasis and regulates cell proliferation, differentiation, development, and apoptosis; however, there is little research about NM23 in promoting liver cell proliferation.
|
29078900 |
2017 |
|
Secondary Neoplasm
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Tumor suppressor gene MTS1/p16 (cyclin-dependent kinase-4 inhibitor) and a putative tumor metastasis suppressor gene nm23 (nucleoside diphosphate A kinase) have been identified in a variety of human tumors but have not been well studied in mesenchymal neoplasms.
|
11223831 |
2001 |