|
Secondary Neoplasm
|
0.100 |
Biomarker
|
group |
BEFREE |
Tumor metastasis is an essential aspect of lung cancer progression. nm23-H1 is a metastasis suppressor gene.
|
18440302 |
2008 |
|
Secondary Neoplasm
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Nm23 expression was significantly reduced and Ki67 antigen expression increased in primary tumours with either lymph node or organ metastases in comparison to tumours without metastases.
|
16277028 |
2005 |
|
Secondary Neoplasm
|
0.100 |
Biomarker
|
group |
BEFREE |
Nm23-H1 is a well-known tumor metastasis suppressor, which functions as a nucleoside-diphosphate kinase converting nucleoside diphosphates to nucleoside triphosphates with an expense of ATP.
|
20448457 |
2010 |
|
Secondary Neoplasm
|
0.100 |
Biomarker
|
group |
BEFREE |
nm23, a tumor metastasis suppressor gene, has been linked to protection against tumorigenesis and tumor metastasis.
|
22683585 |
2012 |
|
Secondary Neoplasm
|
0.100 |
Biomarker
|
group |
BEFREE |
NME1 is a wide-spectrum tumor metastasis suppressor gene that plays an important role in suppressing the invasion and metastasis of tumor cells.
|
23856325 |
2013 |
|
Secondary Neoplasm
|
0.100 |
Biomarker
|
group |
BEFREE |
NM23 is a multifunctional gene, which inhibits tumor metastasis and regulates cell proliferation, differentiation, development, and apoptosis; however, there is little research about NM23 in promoting liver cell proliferation.
|
29078900 |
2017 |
|
Secondary Neoplasm
|
0.100 |
Biomarker
|
group |
BEFREE |
NME1 (also known as NM23-H1) was the first identified tumor metastasis suppressor, which has been reported to link with genomic stability maintenance and cancer.
|
30875636 |
2019 |
|
Secondary Neoplasm
|
0.100 |
AlteredExpression
|
group |
BEFREE |
nm23 was originally identified as an antimetastatic gene, the expression of which was inversely correlated with tumor metastatic potential in rodent model systems.
|
7530600 |
1995 |
|
Secondary Neoplasm
|
0.100 |
Biomarker
|
group |
BEFREE |
Nm23 is a gene associated with low tumor metastatic potential and has been proposed to be a metastasis suppressor gene.
|
8199988 |
1994 |
|
Secondary Neoplasm
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Nm23-H1 gene expression is inversely correlated with tumor metastatic potential in certain tumors, including melanomas, breast carcinomas, and hepatocellular carcinomas.
|
8270257 |
1994 |
|
Secondary Neoplasm
|
0.100 |
AlteredExpression
|
group |
BEFREE |
A more than twofold decreased expression of nm23-H1 mRNA was reported in 28/52 (54%) of the carcinomas and was positively associated with the presence of nodal metastases and Astler-Coller stages B1 and B2 in 29% and 35% of the SCRCs, respectively.
|
12684753 |
2003 |
|
Secondary Neoplasm
|
0.100 |
GeneticVariation
|
group |
BEFREE |
A novel mutation of the nm23 gene was found in one case of stage III serous carcinoma without lymph model metastases.
|
7669582 |
1995 |
|
Secondary Neoplasm
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Although the inverse correlation of Nm23 level with tumor metastasis potential has been widely observed, the mechanisms that regulate the expression of Nm23 remain poorly understood.
|
29050254 |
2017 |
|
Secondary Neoplasm
|
0.100 |
Biomarker
|
group |
BEFREE |
Apart from a housekeeping function, NM23 proteins are involved in the regulation of many cellular processes as well as in tumor metastasis, but their functions in epidermal homeostasis and repair are largely unknown.
|
16862176 |
2007 |
|
Secondary Neoplasm
|
0.100 |
Biomarker
|
group |
BEFREE |
Because of NDPK-A's dichotomous role in tumor metastasis as both a suppressor and a promoter, tumor genome/exome profiles are necessary to identify the molecular drivers of metastasis in the NDPK-A network for developing tumor-specific therapies.
|
28991262 |
2018 |
|
Secondary Neoplasm
|
0.100 |
Biomarker
|
group |
BEFREE |
Finally, nm-23-H1 immunoreactivity was more specific but less sensitive than AMES score to predict metastases.
|
11502841 |
2001 |
|
Secondary Neoplasm
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Furthermore, detection of the changes in expression levels of metastasis‑associated gene 1 (MTA‑1) and tumor metastasis suppressor gene, non‑metastasis protein 23‑H1 (nm23‑H1), and the expression change of autophagy‑associated signal transduction pathway, phosphatidylinositol 3‑kinase (PI3K)/protein kinase B (PKB) kinase were analyzed.
|
27082164 |
2016 |
|
Secondary Neoplasm
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Genetic alterations either as a deletion in the coding sequence of nm23-H1 or as an allelic deletion were detected in four among eight colorectal adenocarcinomas associated with metastases in lymph nodes, lung, or liver.
|
7916650 |
1993 |
|
Secondary Neoplasm
|
0.100 |
AlteredExpression
|
group |
BEFREE |
High level of Nm23-H1 gene expression is associated with local colorectal cancer progression not with metastases.
|
7947079 |
1994 |
|
Secondary Neoplasm
|
0.100 |
AlteredExpression
|
group |
BEFREE |
However, mRNA levels of both nm23 genes were not associated with histological grade, pathological stage, tumor metastasis or prognosis.
|
7614395 |
1994 |
|
Secondary Neoplasm
|
0.100 |
AlteredExpression
|
group |
BEFREE |
However, the authors observed an inverse relationship between nm23-H1 expression and intrahepatic metastases of hepatocellular carcinomas.
|
8168032 |
1994 |
|
Secondary Neoplasm
|
0.100 |
Biomarker
|
group |
BEFREE |
Human c-myc transcription factor PuF identified as nm23-H2 nucleoside diphosphate kinase, a candidate suppressor of tumor metastasis.
|
8392752 |
1993 |
|
Secondary Neoplasm
|
0.100 |
AlteredExpression
|
group |
BEFREE |
In conclusion, our present data indicate that expression of nm23-H1 by a tumor could be altered during the different steps in metastases, suggesting that nm23-H1 may act as a molecular switch between the free-floating and adherent states of cancer cells.
|
11675153 |
2001 |
|
Secondary Neoplasm
|
0.100 |
Biomarker
|
group |
BEFREE |
In sharp contrast, the low frequency of loss at NME1 and its equal distribution in nodal metastasis-positive and -negative patients suggests that inactivation of this gene by allelic loss probably does not play a role in the development of regional metastases from these tumors.
|
8174043 |
1994 |
|
Secondary Neoplasm
|
0.100 |
Biomarker
|
group |
BEFREE |
It is thought that nm23 protein may play a specific biological role in suppressing tumor metastasis.
|
10523705 |
1999 |