|
Neoplasms
|
0.070 |
AlteredExpression
|
group |
BEFREE |
NOP2/Sun domain family member 2 (NSUN2) is upregulated in numerous types of tumors and may be implicated in multiple biological processes, including cell proliferation, migration and human tumorigenesis.
|
30816500 |
2019 |
|
Neoplasms
|
0.070 |
Biomarker
|
group |
BEFREE |
In contrast, indirect inactivation of the adherens junction through conditional knockout of p120 in mice was recently linked to tumor formation, indicating that p120 can also function as a tumor suppressor.
|
23950111 |
2013 |
|
Neoplasms
|
0.070 |
Biomarker
|
group |
BEFREE |
Up-regulation, nuclear import, and tumor growth stimulation of the adhesion protein p120 in pancreatic cancer.
|
12671892 |
2003 |
|
Neoplasms
|
0.070 |
Biomarker
|
group |
BEFREE |
The data reveal a core function of p120 in cadherin complexes, and strongly predict a dose-dependent loss of E-cadherin in tumors that partially or completely down-regulate p120.
|
14610055 |
2003 |
|
Neoplasms
|
0.070 |
AlteredExpression
|
group |
BEFREE |
Expression of betaglycan and p120 in most GCT argues against the hypothesis, but does not exclude the possibility that low or absent expression of p120 might be significant in a subset of these tumors.
|
11889215 |
2002 |
|
Neoplasms
|
0.070 |
Biomarker
|
group |
BEFREE |
Potential roles of p120 as a tumor suppressor or metastasis promoter are discussed.
|
12492499 |
2002 |
|
Neoplasms
|
0.070 |
Biomarker
|
group |
BEFREE |
Previous reports from this laboratory have shown marked cytocidal effects of the ISIS-3466 antisense phosphorothioate oligodeoxynucleotide to the human nucleolar protein p120 on human cancer cell lines in vitro and inhibition of tumor growth in vivo in an i.p/i.p.LOX cell model (L. Perlaky et al.Anti-Cancer Drug Design 8:3-14, 1993).
|
8287366 |
1993 |
|
Malignant Neoplasms
|
0.050 |
AlteredExpression
|
group |
BEFREE |
The present study showed that increased miR-223 and decreased p120 levels are associated with colon cancer malignancy, and p120 expression is negatively correlated with miR-223 expression.
|
28969027 |
2017 |
|
Breast Carcinoma
|
0.050 |
Biomarker
|
disease |
BEFREE |
E-cadherin and p120 did not appear to be useful objective biomarkers for predicting additional relevant findings on MRI in patients with a lobular component in the core needle of their breast cancer.
|
28779344 |
2017 |
|
Primary malignant neoplasm
|
0.050 |
AlteredExpression
|
group |
BEFREE |
The present study showed that increased miR-223 and decreased p120 levels are associated with colon cancer malignancy, and p120 expression is negatively correlated with miR-223 expression.
|
28969027 |
2017 |
|
Malignant Neoplasms
|
0.050 |
Biomarker
|
group |
BEFREE |
Supporting these opposing functions are findings in human cancer, which show that either loss or cytoplasmic localization of p120 is a common feature in the progression of several types of carcinoma.
|
23950111 |
2013 |
|
Primary malignant neoplasm
|
0.050 |
Biomarker
|
group |
BEFREE |
Supporting these opposing functions are findings in human cancer, which show that either loss or cytoplasmic localization of p120 is a common feature in the progression of several types of carcinoma.
|
23950111 |
2013 |
|
Breast Carcinoma
|
0.050 |
AlteredExpression
|
disease |
BEFREE |
Lastly, ectopic expression of p120 promoted migration and invasion and potentiated metastatic progression of a weakly metastatic, ErbB2-dependent breast cancer cell line.
|
20595387 |
2010 |
|
Breast Carcinoma
|
0.050 |
Biomarker
|
disease |
BEFREE |
In addition, studies of tissue microarrays of 80 breast carcinomas with mucinous differentiation revealed 4 pure mucinous carcinomas showing significantly reduced E-cadherin staining without redistribution of p120 into cytoplasm.
|
20550696 |
2010 |
|
Malignant Neoplasms
|
0.050 |
AlteredExpression
|
group |
BEFREE |
Altered expression of the catenin p120 in human cancer: implications for tumor progression.
|
12492499 |
2002 |
|
Primary malignant neoplasm
|
0.050 |
AlteredExpression
|
group |
BEFREE |
Altered expression of the catenin p120 in human cancer: implications for tumor progression.
|
12492499 |
2002 |
|
Breast Carcinoma
|
0.050 |
AlteredExpression
|
disease |
BEFREE |
Next, the mechanisms responsible for the increased level of P120 expression, which is associated with rapidly growing breast carcinoma, were examined.
|
7829252 |
1995 |
|
Malignant Neoplasms
|
0.050 |
Biomarker
|
group |
BEFREE |
Previous reports from this laboratory have shown marked cytocidal effects of the ISIS-3466 antisense phosphorothioate oligodeoxynucleotide to the human nucleolar protein p120 on human cancer cell lines in vitro and inhibition of tumor growth in vivo in an i.p/i.p.LOX cell model (L. Perlaky et al.Anti-Cancer Drug Design 8:3-14, 1993).
|
8287366 |
1993 |
|
Malignant Neoplasms
|
0.050 |
AlteredExpression
|
group |
BEFREE |
Subsequent transfection of these transformed cells with a dexamethasone inducible antisense p120 construct (pMSG021) markedly reduced the expression of human p120 and the growth rate of these transformed cells (Perklaky et al., Cancer Res., (1992) 52, 428-436).
|
8443798 |
1993 |
|
Breast Carcinoma
|
0.050 |
AlteredExpression
|
disease |
BEFREE |
The effect of antisense p120 construct on p120 expression and cell proliferation in human breast cancer MCF-7 cells.
|
8443798 |
1993 |
|
Primary malignant neoplasm
|
0.050 |
AlteredExpression
|
group |
BEFREE |
Subsequent transfection of these transformed cells with a dexamethasone inducible antisense p120 construct (pMSG021) markedly reduced the expression of human p120 and the growth rate of these transformed cells (Perklaky et al., Cancer Res., (1992) 52, 428-436).
|
8443798 |
1993 |
|
Primary malignant neoplasm
|
0.050 |
Biomarker
|
group |
BEFREE |
Previous reports from this laboratory have shown marked cytocidal effects of the ISIS-3466 antisense phosphorothioate oligodeoxynucleotide to the human nucleolar protein p120 on human cancer cell lines in vitro and inhibition of tumor growth in vivo in an i.p/i.p.LOX cell model (L. Perlaky et al.Anti-Cancer Drug Design 8:3-14, 1993).
|
8287366 |
1993 |
|
Tumor Progression
|
0.040 |
Biomarker
|
phenotype |
BEFREE |
Furthermore, we will focus on the contradictory functions of E-cadherin and p120 in the different phases of tumor progression, from carcinoma in situ up to the formation of distant metastasis.
|
31369816 |
2020 |
|
Tumor Progression
|
0.040 |
AlteredExpression
|
phenotype |
BEFREE |
In cancer, reduced p120 expression correlates with reduced E-cadherin function and with tumor progression.
|
23481205 |
2013 |
|
Tumor Progression
|
0.040 |
Biomarker
|
phenotype |
BEFREE |
Here, we discuss past and present findings that implicate p120 in the regulation of cancer progression and highlight opportunities for clinical intervention.
|
23950111 |
2013 |