NOS1, nitric oxide synthase 1, 4842

N. diseases: 521; N. variants: 38
Disease: Impulsive Behavior ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0021125
Disease: Impulsive Behavior
Impulsive Behavior 		0.100 GeneticVariation phenotype BEFREE Regarding the NOS1 ex1f-VNTR our study supports the previously reported influence on impulsivity, lending further support to the hypothesis that this genetic variant underlies impulsive behavior. 31002875 2019
CUI: C0021125
Disease: Impulsive Behavior
Impulsive Behavior 		0.100 GeneticVariation phenotype BEFREE Impulsivity SNAP-IV scores were also significantly different according to NOS1 rs478597 polymorphisms in adults with ADHD (F = 6.282; adjusted P-value = 0.026). 26821215 2016
CUI: C0021125
Disease: Impulsive Behavior
Impulsive Behavior 		0.100 AlteredExpression phenotype BEFREE Also, reduced NOS1 expression in the striatum determined by a length polymorphism in a NOS1 promoter (NOS1 ex1f-VNTR) goes along with a variety of impulsive behaviors. 25612209 2015
CUI: C0021125
Disease: Impulsive Behavior
Impulsive Behavior 		0.100 GeneticVariation phenotype BEFREE One of the molecular determinants involved is the NOS1 ex1f-VNTR, whose short variants are associated with a variety of impulsive behaviors. 21922604 2012
CUI: C0021125
Disease: Impulsive Behavior
Impulsive Behavior 		0.100 GeneticVariation phenotype BEFREE A functional promoter polymorphism of the nitric oxide synthase 1 gene first exon 1f variable number tandem repeat (NOS1 ex1f-VNTR) is associated with impulsivity and related psychopathology. 23062293 2012
CUI: C0021125
Disease: Impulsive Behavior
Impulsive Behavior 		0.100 Biomarker phenotype BEFREE A functional variable number of tandem repeats (VNTR) polymorphism in the promoter region of the alternative first exon 1f of NOS1 is associated with various functions of human behavior, for example increased impulsivity, while another, non-functional variant was linked to decreased verbal working memory and a heightened risk for schizophrenia. 21620982 2011
CUI: C0021125
Disease: Impulsive Behavior
Impulsive Behavior 		0.100 GeneticVariation phenotype BEFREE This study provides further evidence that short alleles of NOS1 ex1f-VNTR go along with impulsive behavior. 20589495 2011
CUI: C0021125
Disease: Impulsive Behavior
Impulsive Behavior 		0.100 GeneticVariation phenotype BEFREE The effect of the NOS1 exon 1f-VNTR genotype on reward-related impulsivity and reward-related ventral striatal activity was examined. 21724667 2011
CUI: C0021125
Disease: Impulsive Behavior
Impulsive Behavior 		0.100 GeneticVariation phenotype BEFREE Further, several polymorphisms of neuronal nitric oxide synthase (NOS1) gene have been reported to be associated with impulsivity, aggression and suicide attempts. 20470850 2010
CUI: C0021125
Disease: Impulsive Behavior
Impulsive Behavior 		0.100 GeneticVariation phenotype BEFREE Impulsivity and in particular the aspects of adaptive impulsivity (e.g. fast decision-making and excitement-seeking behaviour) were higher in subjects with the NOS1 ex1f-VNTR short/short genotype if they belonged to the platelet MAO medium activity (interquartile) range. 20186396 2010
CUI: C0021125
Disease: Impulsive Behavior
Impulsive Behavior 		0.100 Biomarker phenotype BEFREE The findings give additional evidence that NOS-I is involved in the regulation of impulsive personality traits and support the notion that the NOS1 gene takes part in the regulation of social behavior. 19997858 2010
CUI: C0021125
Disease: Impulsive Behavior
Impulsive Behavior 		0.100 GeneticVariation phenotype BEFREE A novel functional promoter polymorphism in NOS1 was associated with traits related to impulsivity, including hyperactive and aggressive behaviors. 19124687 2009