NOS2, nitric oxide synthase 2, 4843

N. diseases: 783; N. variants: 28
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0006142
Disease: Malignant neoplasm of breast
Malignant neoplasm of breast 		0.600 GeneticVariation disease UNIPROT
CUI: C0024530
Disease: Malaria
Malaria 		0.400 Biomarker disease CTD_human
CUI: C0085580
Disease: Essential Hypertension
Essential Hypertension 		0.330 Biomarker disease CTD_human
CUI: C0011854
Disease: Diabetes Mellitus, Insulin-Dependent
Diabetes Mellitus, Insulin-Dependent 		0.250 Biomarker disease MGD
CUI: C1840374
Disease: Elevated systolic blood pressure
Elevated systolic blood pressure 		0.100 Biomarker phenotype HPO
CUI: C1840375
Disease: Elevated diastolic blood pressure
Elevated diastolic blood pressure 		0.100 Biomarker phenotype HPO
CUI: C1840376
Disease: Elevated mean arterial pressure
Elevated mean arterial pressure 		0.100 Biomarker phenotype HPO
CUI: C0020672
Disease: Hypothermia, natural
Hypothermia, natural 		0.300 Therapeutic phenotype CTD_human α-Lipoic acid protects mitochondrial enzymes and attenuates lipopolysaccharide-induced hypothermia in mice. 24675228 2014
CUI: C0740391
Disease: Middle Cerebral Artery Occlusion
Middle Cerebral Artery Occlusion 		0.020 AlteredExpression disease BEFREE <b>Results:</b> The data showed that miR-122 mimic decreased infarct volumes and decreased MCAO-induced NOS2 over-expression in BMVECs. 30405345 2018
CUI: C0338462
Disease: Semantic Dementia
Semantic Dementia 		0.010 Biomarker disease BEFREE <i>GRN</i>, PPA-NOS and SD were the subgroups showing the highest asymmetry in volumes. 29876259 2018
CUI: C0004096
Disease: Asthma
Asthma 		0.600 GeneticVariation disease LHGDN (CCTTT)n polymorphism of NOS2A in nasal polyposis and asthma: a case-control study. 18714530 2008
CUI: C0004096
Disease: Asthma
Asthma 		0.600 GeneticVariation disease BEFREE (CCTTT)n polymorphism of NOS2A in nasal polyposis and asthma: a case-control study. 18714530 2008
CUI: C1269955
Disease: Tumor Cell Invasion
Tumor Cell Invasion 		0.070 AlteredExpression phenotype BEFREE (ii) JQ1 at minimally toxic concentrations had no effect on Brd4 or p65-acK up-regulation after PDT but strongly suppressed iNOS, survivin, and Bcl-xL up-regulation, along with the growth and invasion spurt of PDT-surviving cells. 29440272 2018
CUI: C0001308
Disease: Acute and subacute liver necrosis (disorder)
Acute and subacute liver necrosis (disorder) 		0.200 Biomarker disease RGD (Z)2-(5-(4-methoxybenzylidene)-2, 4-dioxothiazolidin-3-yl) acetic acid protects rats from CCl(4) -induced liver injury. 21913985 2012
CUI: C0019189
Disease: Hepatitis, Chronic
Hepatitis, Chronic 		0.200 Biomarker disease RGD (Z)2-(5-(4-methoxybenzylidene)-2, 4-dioxothiazolidin-3-yl) acetic acid protects rats from CCl(4) -induced liver injury. 21913985 2012
CUI: C0149519
Disease: Chronic Persistent Hepatitis
Chronic Persistent Hepatitis 		0.200 Biomarker disease RGD (Z)2-(5-(4-methoxybenzylidene)-2, 4-dioxothiazolidin-3-yl) acetic acid protects rats from CCl(4) -induced liver injury. 21913985 2012
CUI: C0267797
Disease: Acute hepatitis
Acute hepatitis 		0.200 Biomarker disease RGD (Z)2-(5-(4-methoxybenzylidene)-2, 4-dioxothiazolidin-3-yl) acetic acid protects rats from CCl(4) -induced liver injury. 21913985 2012
CUI: C0038454
Disease: Cerebrovascular accident
Cerebrovascular accident 		0.560 AlteredExpression group BEFREE 0 or 6 h after MCAO, and assessed stroke volume and NOS2 expression in BMVECs 24 h following MCAO in rats. 30405345 2018
CUI: C0038525
Disease: Subarachnoid Hemorrhage
Subarachnoid Hemorrhage 		0.310 Biomarker disease CTD_human 17beta-Estradiol inhibits subarachnoid hemorrhage-induced inducible nitric oxide synthase gene expression by interfering with the nuclear factor kappa B transactivation. 17053178 2006
CUI: C0270192
Disease: Perinatal Subarachnoid Hemorrhage
Perinatal Subarachnoid Hemorrhage 		0.300 Biomarker phenotype CTD_human 17beta-Estradiol inhibits subarachnoid hemorrhage-induced inducible nitric oxide synthase gene expression by interfering with the nuclear factor kappa B transactivation. 17053178 2006
CUI: C0472383
Disease: Subarachnoid Hemorrhage, Spontaneous
Subarachnoid Hemorrhage, Spontaneous 		0.300 Biomarker phenotype CTD_human 17beta-Estradiol inhibits subarachnoid hemorrhage-induced inducible nitric oxide synthase gene expression by interfering with the nuclear factor kappa B transactivation. 17053178 2006
CUI: C0751530
Disease: Subarachnoid Hemorrhage, Aneurysmal
Subarachnoid Hemorrhage, Aneurysmal 		0.300 Biomarker phenotype CTD_human 17beta-Estradiol inhibits subarachnoid hemorrhage-induced inducible nitric oxide synthase gene expression by interfering with the nuclear factor kappa B transactivation. 17053178 2006
CUI: C0795688
Disease: Subarachnoid Hemorrhage, Intracranial
Subarachnoid Hemorrhage, Intracranial 		0.300 Biomarker phenotype CTD_human 17beta-Estradiol inhibits subarachnoid hemorrhage-induced inducible nitric oxide synthase gene expression by interfering with the nuclear factor kappa B transactivation. 17053178 2006
CUI: C0023531
Disease: Leukoplakia
Leukoplakia 		0.010 Biomarker disease LHGDN 8-Nitroguanine formation in oral leukoplakia, a premalignant lesion. 16290060 2006
CUI: C0027051
Disease: Myocardial Infarction
Myocardial Infarction 		0.340 Biomarker disease CTD_human Myocardial infarction was induced by ligation of the left anterior descending coronary artery (LAD), and tissue was collected at selected times thereafter from both ligated and sham-operated rats. iNOS mRNA was induced in the infarcted region of the left ventricle for 7 days; iNOS protein was also detected in the infarcted area. 10090345 1999