Anemia, Sickle Cell
|
0.090 |
Biomarker
|
disease |
BEFREE |
The haemodynamic changes in SCD mice that had lived at mild and moderate altitude were accompanied by changes in the balance between pulmonary vascular endothelial nitric oxide synthase and endothelin receptor expression and impaired exercise tolerance.
|
29931797 |
2019 |
Anemia, Sickle Cell
|
0.090 |
Biomarker
|
disease |
BEFREE |
Disturbances in these processes in SCD were detailed considering the functions of endothelial nitric oxide synthase (eNOS), arginase and asymmetric dimethylarginine (ADMA).
|
30855194 |
2019 |
Anemia, Sickle Cell
|
0.090 |
GeneticVariation
|
disease |
BEFREE |
Our aim was to determine eNOS genotype for T786C and G894T polymorphisms in Greek patients with SCD and to elucidate its consequences and effects if any on clinical phenotype.
|
27871907 |
2017 |
Anemia, Sickle Cell
|
0.090 |
GeneticVariation
|
disease |
BEFREE |
We studied the 27-base pair tandem repeat polymorphism in intron 4 of eNOS gene in 51 patients with SCD compared with 55 healthy controls and evaluated its role in disease severity and hemolysis-associated complications.
|
25263931 |
2015 |
Anemia, Sickle Cell
|
0.090 |
AlteredExpression
|
disease |
BEFREE |
Genetic variation in CD36, HBA, NOS3 and VCAM1 is associated with chronic haemolysis level in sickle cell anaemia: a longitudinal study.
|
24168396 |
2014 |
Anemia, Sickle Cell
|
0.090 |
GeneticVariation
|
disease |
BEFREE |
Haplotype analysis revealed that frequencies of one mutant haplotype '4a-T-C' (alleles in order of eNOS 4a/b, eNOS 894G>T and eNOS -786T>C) were significantly high in the severe SCD patients (P<0.0001), whereas the frequency of a wild haplotype '4b-G-T' was found to be significantly high (P<0.0001) in the SCD mild patients, which indicates that eNOS gene polymorphisms are associated with SCD patients in India and may act as a genetic modifier of the phenotypic variation of SCD patients.
|
24088668 |
2013 |
Anemia, Sickle Cell
|
0.090 |
GeneticVariation
|
disease |
BEFREE |
ET-1 and ecNOS gene polymorphisms andsusceptibility to acute chest syndrome and painful vaso-occlusive crises in children with sickle cell anemia.
|
16956834 |
2006 |
Anemia, Sickle Cell
|
0.090 |
GeneticVariation
|
disease |
BEFREE |
Multiple logistic regression analysis showed that relative risk of ACS was 8.695 (P = 0.0076, 95% confidence interval 1.761-42.920) for female carriers of C-786. eNOS T-786C is a gender-specific genetic modifier that is associated with increased susceptibility to ACS in female SCD patients.
|
14687036 |
2004 |
Anemia, Sickle Cell
|
0.090 |
Biomarker
|
disease |
BEFREE |
Hypoxia further decreased association of HSP90 with eNOS in lungs of SCD and heterozygote SCD mice, but not in the control lungs.
|
12972407 |
2004 |