|
Coronary heart disease
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
We found that current smokers with rs1799983-GT or TT within eNOS gene have the highest CHD risk, compared to never smokers with rs1799983-GG genotype, OR (95% CI) = 2.74 (1.78-3.85), after covariates adjustment for age, gender, BMI, and alcohol drinking.
|
31567371 |
2020 |
|
Coronary heart disease
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Odds ratios with 95% confidence intervals were used to evaluate associations between endothelial nitric oxide synthase polymorphisms and coronary artery disease.
|
30789045 |
2019 |
|
Coronary heart disease
|
0.100 |
Biomarker
|
disease |
BEFREE |
Maternal treatment with sapropterin, a cofactor of eNOS, and antioxidants such as N-acetylcysteine, vitamin E, and glutathione as well as maternal exercise have been shown to improve eNOS function, reduce oxidative stress, and lower the incidence CHDs in the offspring of mice with pregestational diabetes.
|
31581464 |
2019 |
|
Coronary heart disease
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The contribution of NOS3 variants to coronary artery disease: A combined genetic epidemiology and computational biochemistry perspective.
|
30447355 |
2019 |
|
Coronary heart disease
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
In conclusion, the eNOS G894T gene polymorphism was associated with the occurrence and development of CHD in young people.
|
29359785 |
2018 |
|
Coronary heart disease
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Association Patterns of Endothelial Nitric Oxide Synthase Gene (NOS3) Variant Glu298Asp with Blood Pressure and Serum Lipid Levels in Subjects with Coronary Artery Disease from Pakistan.
|
28620990 |
2017 |
|
Coronary heart disease
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Association of the Endothelial Nitric Oxide Synthase Gene T786C Polymorphism with In-Stent Restenosis in Chinese Han Patients with Coronary Artery Disease Treated with Drug-Eluting Stent.
|
28129392 |
2017 |
|
Coronary heart disease
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Assessment of the role of plasma nitric oxide levels, T-786C genetic polymorphism, and gene expression levels of endothelial nitric oxide synthase in the development of coronary artery disease.
|
28461820 |
2017 |
|
Coronary heart disease
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Association between NOS3 genetic variants and coronary artery disease in the Han population.
|
27323132 |
2016 |
|
Coronary heart disease
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
In this study, we investigated the association between -786T/C polymorphism of the endothelial nitric oxide (NOS3) gene in which thymidine is replaced by a cytosine at nucleotide -786 (rs 2070744) and coronary collateral circulation (CCC) in patients with stable coronary artery disease.
|
26864067 |
2016 |
|
Coronary heart disease
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Association of Cholesteryl Ester Transfer Protein and Endothelial Nitric Oxide Synthase Gene Polymorphisms With Coronary Artery Disease in the Multi-Ethnic Malaysian Population.
|
25667236 |
2016 |
|
Coronary heart disease
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Genetic etiology of coronary artery disease considering NOS 3 gene variant rs1799983.
|
25057159 |
2015 |
|
Coronary heart disease
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
We investigated the association of the T-786C single nucleotide polymorphism (SNP) of the endothelial nitric oxide synthase gene (NOS3), which is characterised by reduced expression of the enzyme in response to shear stress or interleukin-10 stimulation and significantly associated with coronary heart disease or rheumatoid arthritis, with the occurrence of isolated polymyalgia rheumatica.
|
26314610 |
2015 |
|
Coronary heart disease
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
We enrolled 1977 Japanese type 2 diabetic subjects without history of CVD (males 66.1%, 59.5 ± 10.0 years old), determined their genotypes regarding glutamate-cysteine ligase modifier subunit (GCLM) C-588T, manganese superoxide dismutase (SOD2) Val16Ala, endothelial nitric oxide synthase (NOS3) G894T, NAD(P)H oxidase p22phox (CYBA) C242T, and myeloperoxidase (MPO) G-463A polymorphisms, and prospectively evaluated the association between these polymorphisms and CHD events.
|
24933031 |
2014 |
|
Coronary heart disease
|
0.100 |
Biomarker
|
disease |
BEFREE |
Gene-gene interaction of ACE I/D, endothelial nitric oxide synthase 4 a/b and ApoE does not affect coronary artery disease severity.
|
24913112 |
2014 |
|
Coronary heart disease
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Endothelial nitric oxide synthase (eNOS) 4b/a gene polymorphisms and coronary artery disease: evidence from a meta-analysis.
|
24810690 |
2014 |
|
Coronary heart disease
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
A polymorphism in the endothelial nitric oxide synthase (eNOS) gene, which reduces eNOS activity, might be a risk factor for coronary heart diseases.However, its role in CAE is unknown.
|
24573064 |
2014 |
|
Coronary heart disease
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Association of endothelial nitric oxide synthase gene polymorphisms with coronary artery disease: an updated meta-analysis and systematic review.
|
25409023 |
2014 |
|
Coronary heart disease
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Association between the - 786T>C 1polymorphism in the promoter region of endothelial nitric oxide synthase (eNOS) and risk of coronary artery disease: a systematic review and meta-analysis.
|
24135644 |
2014 |
|
Coronary heart disease
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Association of the genetic variants of endothelial nitric oxide synthase gene with angiographically defined coronary artery disease and myocardial infarction in South Indian patients with type 2 diabetes mellitus.
|
23182401 |
2013 |
|
Coronary heart disease
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The results indicated that the eNOS Glu298Asp polymorphism is a risk factor for developing CHD, particularly in the Asian population.
|
23443250 |
2013 |
|
Coronary heart disease
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Association of endothelial nitric oxide synthase gene variant (G894T) with coronary artery disease in Western Iran.
|
21602253 |
2012 |
|
Coronary heart disease
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Strong interaction between T allele of endothelial nitric oxide synthase with B1 allele of cholesteryl ester transfer protein TaqIB highly elevates the risk of coronary artery disease and type 2 diabetes mellitus.
|
23157875 |
2012 |
|
Coronary heart disease
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The G894T polymorphism on endothelial nitric oxide synthase gene is associated with increased coronary heart disease among Asia population: evidence from a Meta analysis.
|
22417945 |
2012 |
|
Coronary heart disease
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Glu298Asp polymorphism of the endothelial nitric oxide synthase (eNOS) gene (NOS3) has been characterized as a risk factor of hypertension and coronary artery disease.
|
21816783 |
2011 |