Diabetic Retinopathy
|
0.300 |
GeneticVariation
|
disease |
BEFREE |
In conclusion, our results indicate that NOS3 rs869109213 polymorphism alone or in a combination with EDNRB rs10507875 polymorphism may be associated with DR in Slovenian patients with T2DM.
|
28817788 |
2018 |
Diabetic Retinopathy
|
0.300 |
Biomarker
|
disease |
BEFREE |
Our results suggest that 1) IGFBP-3 inhibits the endothelial nitric oxide synthase (eNOS) and protein kinase C zeta (PKCzeta) pathway, which in turn inhibits VEGF production, and 2) that eNOS plays a role in activating PKCzeta to increase VEGF levels in diabetic retinopathy.
|
26015772 |
2015 |
Diabetic Retinopathy
|
0.300 |
GeneticVariation
|
disease |
BEFREE |
The present meta-analysis suggests that the eNOS 27VNTR (4b/4a) polymorphism potentially decreases the risk of developing DR in T2DM African individuals.
|
24673412 |
2014 |
Diabetic Retinopathy
|
0.300 |
Biomarker
|
disease |
RGD |
Simvastatin increases circulating endothelial progenitor cells and reduces the formation and progression of diabetic retinopathy in rats.
|
23059402 |
2012 |
Diabetic Retinopathy
|
0.300 |
GeneticVariation
|
disease |
BEFREE |
In this case-control study, the relationship of the -786T/C, the VNTR intron 4 a/b and the 894G/T (Glu298Asp) polymorphisms in the eNOS gene with the presence or severity of diabetic retinopathy was analyzed in 630 Caucasian-Brazilians with type 2 diabetes (434 with and 196 without diabetic retinopathy).
|
22017289 |
2012 |
Diabetic Retinopathy
|
0.300 |
GeneticVariation
|
disease |
BEFREE |
Our results suggest that eNOS genotypes 27VNTR carrying "aa" genotype is an independent protective factor for DR and is associated with low risk of DR.
|
23085930 |
2012 |
Diabetic Retinopathy
|
0.300 |
GeneticVariation
|
disease |
BEFREE |
The intron 4a allele of the 4b/a polymorphism in the eNOS gene has protective effects against DR, especially in type 2 diabetic patients.
|
22506535 |
2012 |
Diabetic Retinopathy
|
0.300 |
Biomarker
|
disease |
BEFREE |
Therefore, eNOS gene variation may be a factor in the genetic propensity to T1DM and diabetic retinopathy that may have a prognostic value or may suggest interventional approaches to regulate eNOS in patients with diabetes.
|
20565248 |
2010 |
Diabetic Retinopathy
|
0.300 |
Therapeutic
|
disease |
RGD |
Rho kinase inhibition by fasudil ameliorates diabetes-induced microvascular damage.
|
18840783 |
2009 |
Diabetic Retinopathy
|
0.300 |
GeneticVariation
|
disease |
BEFREE |
The possible association between the endothelial nitric oxide (eNOS) gene T-786C (promoter region), 27-bp repeat 4b/4a (intron 4), and Glu298Asp (exon 7) polymorphisms with diabetic retinopathy (DR) was investigated.
|
17973941 |
2008 |
Diabetic Retinopathy
|
0.300 |
GeneticVariation
|
disease |
BEFREE |
A significantly higher frequency of the VV genotype of the V16A polymorphism of the Mn-SOD was found in patients with diabetic retinopathy compared to those without diabetic retinopathy (OR=2.1, 95% whereas the 4a/b polymorphism of the eNOS gene failed to yield an association with diabetic retinopathy.
|
18057537 |
2008 |
Diabetic Retinopathy
|
0.300 |
GeneticVariation
|
disease |
BEFREE |
Our results suggest lack of association of intron 4 VNTR of eNOS gene with DR in southern India.
|
17558849 |
2007 |
Diabetic Retinopathy
|
0.300 |
GeneticVariation
|
disease |
LHGDN |
Polymorphism of the endothelial nitric oxide synthase gene is associated with diabetic retinopathy in a cohort of West Africans.
|
18079690 |
2007 |
Diabetic Retinopathy
|
0.300 |
GeneticVariation
|
disease |
BEFREE |
Polymorphism of the endothelial nitric oxide synthase gene is associated with diabetic retinopathy in a cohort of West Africans.
|
18079690 |
2007 |
Diabetic Retinopathy
|
0.300 |
GeneticVariation
|
disease |
BEFREE |
The objective of this study was to examine the genetic variations of the VEGF and eNOS gene and assess their possible relationship to DR in type 2 diabetic patients in the Indian population.
|
16636650 |
2006 |
Diabetic Retinopathy
|
0.300 |
GeneticVariation
|
disease |
LHGDN |
The objective of this study was to examine the genetic variations of the VEGF and eNOS gene and assess their possible relationship to DR in type 2 diabetic patients in the Indian population.
|
16636650 |
2006 |
Diabetic Retinopathy
|
0.300 |
GeneticVariation
|
disease |
BEFREE |
These findings suggest no association between DR and individual eNOS haplotypes in T2DM patients.
|
16581274 |
2006 |
Diabetic Retinopathy
|
0.300 |
GeneticVariation
|
disease |
BEFREE |
These findings, supported by previous associations between eNOS4b/a polymorphism and DR, suggest that T-786C and C774T eNOS polymorphisms affect the onset pattern of severe DR.
|
15890549 |
2005 |
Diabetic Retinopathy
|
0.300 |
GeneticVariation
|
disease |
BEFREE |
We examined the endothelial nitric oxide (eNOS) gene polymorphisms to assess its possible association with diabetic retinopathy and macular edema.
|
15333482 |
2004 |
Diabetic Retinopathy
|
0.300 |
GeneticVariation
|
disease |
BEFREE |
Our results do not support the hypothesis that the ecNOS 4 a/b polymorphism interacts with the development of early carotid arteriosclerosis in young type-1 diabetic patients, but they give grounds to assume that in these patients it could influence the occurence of diabetic retinopathy.
|
12605344 |
2003 |
Diabetic Retinopathy
|
0.300 |
GeneticVariation
|
disease |
LHGDN |
Our results do not support the hypothesis that the ecNOS 4 a/b polymorphism interacts with the development of early carotid arteriosclerosis in young type-1 diabetic patients, but they give grounds to assume that in these patients it could influence the occurence of diabetic retinopathy.
|
12605344 |
2003 |
Diabetic Retinopathy
|
0.300 |
GeneticVariation
|
disease |
BEFREE |
eNOS4 polymorphism of the endothelial nitric oxide synthase predicts risk for severe diabetic retinopathy.
|
11918626 |
2002 |
Diabetic Retinopathy
|
0.300 |
GeneticVariation
|
disease |
LHGDN |
eNOS4 polymorphism of the endothelial nitric oxide synthase predicts risk for severe diabetic retinopathy.
|
11918626 |
2002 |
Diabetic Retinopathy
|
0.300 |
GeneticVariation
|
disease |
BEFREE |
Polymorphic variability in the EDN1 and NOS3 genes does not appear to have a major impact on determining susceptibility or resistance to diabetic retinopathy.
|
10450377 |
1999 |