|
Kidney Failure, Chronic
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
It was also found that acupuncture significantly reduced the levels of TNF‑α, Smad3, ILK and TGF‑β expression, dramatically decreased the concentrations of TGF‑β, IL‑8, TNF‑α and IL‑1β in blood serum, and significantly increased eNOS expression in the CRF model rabbits by affecting the TGF‑β/Smad signaling pathway.
|
31322212 |
2019 |
|
Kidney Failure, Chronic
|
0.300 |
Therapeutic
|
disease |
RGD |
Increased circulating trimethylamine N-oxide contributes to endothelial dysfunction in a rat model of chronic kidney disease.
|
29247650 |
2018 |
|
Kidney Failure, Chronic
|
0.300 |
SusceptibilityMutation
|
disease |
RGD |
Role of Nitric Oxide Pathway in Development and Progression of Chronic Kidney Disease in Rats Sensitive and Resistant to its Occurrence in an Experimental Model of 5/6 Nephrectomy.
|
29018182 |
2017 |
|
Kidney Failure, Chronic
|
0.300 |
GeneticVariation
|
disease |
BEFREE |
Variants of eNOS gene might play different roles in the ESRD progression in ADPKD.
|
24995932 |
2014 |
|
Kidney Failure, Chronic
|
0.300 |
GeneticVariation
|
disease |
BEFREE |
Sixteen articles were identified for the analysis of association between eNOS gene polymorphisms and ESRD risk.
|
24673298 |
2014 |
|
Kidney Failure, Chronic
|
0.300 |
GeneticVariation
|
disease |
BEFREE |
However, a link between eNOS Glu298Asp gene polymorphism and ESRD risk was not found in Caucasians and Brazil population.
|
23464568 |
2013 |
|
Kidney Failure, Chronic
|
0.300 |
GeneticVariation
|
disease |
BEFREE |
Four polymorphisms showed association with ESRD: rs1801275 in the interleukin 4 receptor (IL4R) gene (OR: 0.66 (95%CI = 0.46-0.95); p = 0.025; overdominant model), rs4586 in chemokine (C-C motif) ligand 2 (CCL2) gene (OR: 0.70 (95%CI = 0.54-0.90); p = 0.005; additive model), rs301640 located in an intergenic binding site for signal transducer and activator of transcription 4 (STAT4) (OR: 1.82 (95%CI = 1.17-2.83); p = 0.006; additive model) and rs7830 in the nitric oxide synthase 3 (NOS3) gene (OR: 1.31 (95%CI = 1.01-1.71); p = 0.043; additive model).
|
22817530 |
2012 |
|
Kidney Failure, Chronic
|
0.300 |
Biomarker
|
disease |
BEFREE |
Overall these findings form preliminary evidence that disturbed interaction between CAV-1 and eNOS may be of relevance for arterial disease in ESRD and perhaps in other human diseases.
|
21976276 |
2012 |
|
Kidney Failure, Chronic
|
0.300 |
GeneticVariation
|
disease |
BEFREE |
This suggests that the ecNOS gene polymorphism may be associated with an increased risk of chronic renal failure.
|
21519233 |
2011 |
|
Kidney Failure, Chronic
|
0.300 |
GeneticVariation
|
disease |
BEFREE |
However, larger future prospective studies are required to confirm the role of eNOS gene polymorphism in the progression of diabetic nephropathy to ESRD.
|
21854353 |
2011 |
|
Kidney Failure, Chronic
|
0.300 |
GeneticVariation
|
disease |
BEFREE |
The relationship between endothelial nitric oxide synthase (eNOS), methylenetetrahydrofolate reductase (MTHFR) gene polymorphisms and cardiovascular disease (CVD) in Tunisian patients with chronic renal disease (CRD) has not been examined.
|
19376104 |
2009 |
|
Kidney Failure, Chronic
|
0.300 |
GeneticVariation
|
disease |
LHGDN |
The distribution of C/T alleIes is significantly different between rapid and slow ADPKD progressors leading to the conclusion that the T allele of the Glu298Asp polymorphism of NOS3 gene is associated with earlier progression to ESRD in ADPKD patients.
|
18815450 |
2008 |
|
Kidney Failure, Chronic
|
0.300 |
GeneticVariation
|
disease |
BEFREE |
The distribution of C/T alleIes is significantly different between rapid and slow ADPKD progressors leading to the conclusion that the T allele of the Glu298Asp polymorphism of NOS3 gene is associated with earlier progression to ESRD in ADPKD patients.
|
18815450 |
2008 |
|
Kidney Failure, Chronic
|
0.300 |
GeneticVariation
|
disease |
BEFREE |
Our data also suggest that an interaction effect may exist between ACE (I/D) and eNOS (G894 --> T) polymorphism in increasing the risk of vascular complications in ESRD patients.
|
18629615 |
2008 |
|
Kidney Failure, Chronic
|
0.300 |
GeneticVariation
|
disease |
LHGDN |
The aim of the present study was to examine the Glu298Asp polymorphism of endothelial nitric oxide synthase (eNOS) in patients with end-stage renal disease (ESRD).
|
18793530 |
2008 |
|
Kidney Failure, Chronic
|
0.300 |
Biomarker
|
disease |
RGD |
Urine levels of NOx and the expression of glomerular eNOS and tubulointerstitial nNOS were significantly decreased in CRF rats compared with normal rats.
|
18089446 |
2008 |
|
Kidney Failure, Chronic
|
0.300 |
GeneticVariation
|
disease |
BEFREE |
The aim of the present study was to examine the Glu298Asp polymorphism of endothelial nitric oxide synthase (eNOS) in patients with end-stage renal disease (ESRD).
|
18793530 |
2008 |
|
Kidney Failure, Chronic
|
0.300 |
GeneticVariation
|
disease |
LHGDN |
The aim of this study was to investigate the presence of eNOS gene intron 4 polymorphism in patients with end-stage renal disease (ESRD).
|
17498125 |
2007 |
|
Kidney Failure, Chronic
|
0.300 |
GeneticVariation
|
disease |
BEFREE |
The aim of this study was to investigate the presence of eNOS gene intron 4 polymorphism in patients with end-stage renal disease (ESRD).
|
17498125 |
2007 |
|
Kidney Failure, Chronic
|
0.300 |
GeneticVariation
|
disease |
BEFREE |
The results disclosed that the ACE polymorphism had a slight influence on the age of onset of ESRD in ADPKD patients and the NOS3 and BDKBR1 polymorphisms showed a very slight involvement in renal outcome.
|
17303584 |
2007 |
|
Kidney Failure, Chronic
|
0.300 |
GeneticVariation
|
disease |
BEFREE |
Atherosclerosis and the Glu298Asp polymorphism of the eNOS gene in white patients with end-stage renal disease.
|
16364824 |
2005 |
|
Kidney Failure, Chronic
|
0.300 |
AlteredExpression
|
disease |
LHGDN |
A time-dependent decrease in eNOS protein levels was evident in cultures treated with erythrocytes from ESRD patients.
|
15840037 |
2005 |
|
Kidney Failure, Chronic
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
A time-dependent decrease in eNOS protein levels was evident in cultures treated with erythrocytes from ESRD patients.
|
15840037 |
2005 |
|
Kidney Failure, Chronic
|
0.300 |
GeneticVariation
|
disease |
BEFREE |
However, eNOS genotype showed a significant association with cardiovascular mortality in statistical models, including traditional risk factors and factors peculiar to ESRD, and became even stronger when plasma ADMA was forced into the Cox model (P=0.006).
|
16148605 |
2005 |
|
Kidney Failure, Chronic
|
0.300 |
GeneticVariation
|
disease |
BEFREE |
This suggests that the ecNOS gene polymorphism may be associated with an increased risk of chronic renal failure.
|
15299097 |
2004 |