|
Neoplasms
|
0.400 |
GeneticVariation
|
group |
BEFREE |
The results showed that 272 men with UCC having eNOS 894 G > T rs1799983 "GT + TT" variants had a high risk of developing a large tumor (T1-T4, P = 0.038).
|
30611644 |
2019 |
|
Neoplasms
|
0.400 |
Biomarker
|
group |
BEFREE |
In conclusion, this study highlights sONE as a downregulated tumor suppressor lncRNA in TNBC cells acting through repressing eNOS-induced NO production, affecting TP53 and c-Myc proteins levels and finally altering the levels of a panel of tumor suppressor miRNAs downstream TP53/c-Myc proteins.
|
30968427 |
2019 |
|
Neoplasms
|
0.400 |
AlteredExpression
|
group |
BEFREE |
Baseline inflammatory indexes were significantly higher in left-sided tumors, whereas eNOS and EPHB4 expression was significantly higher and <i>BRAF</i> mutation more frequent in right-sided tumors.
|
28598398 |
2017 |
|
Neoplasms
|
0.400 |
Biomarker
|
group |
BEFREE |
In glioma cells and the tumor microenvironment, NO is produced by three isoforms of nitric oxide synthase (NOS), NOS1, NOS2, and NOS3.
|
27411305 |
2017 |
|
Neoplasms
|
0.400 |
Biomarker
|
group |
BEFREE |
HG/U46619-induced reductions of p-eNOS and p-Akt were accompanied with increases of total and phosphorylated tumor suppressor phosphatase and tensin homolog on chromosome 10 (PTEN).
|
28942103 |
2017 |
|
Neoplasms
|
0.400 |
Biomarker
|
group |
BEFREE |
Nitric oxide (NO), which is derived from endothelial nitric oxide synthase (eNOS), provides crucial signals for angiogenesis in the tumor microenvironment.
|
27279530 |
2016 |
|
Neoplasms
|
0.400 |
GeneticVariation
|
group |
BEFREE |
Stratified analyses by tumor stage showed that eNOS -786T>C polymorphism was only associated with the risk of tumor stage III and IV.In conclusion, our meta-analysis and case-control study suggest that eNOS -786T>C and 894G>T polymorphisms are associated with the increased risk of breast cancer.
|
26131841 |
2015 |
|
Neoplasms
|
0.400 |
Biomarker
|
group |
BEFREE |
These results revealed a possible novel mechanism whereby ephrin-A1 is regulated in tumor microenvironment and promotes angiogenesis through a coordinated cross-talk with PI3K/Akt-dependent eNOS activation which may relate to normal vascular development and tumor neovascularization.
|
24040255 |
2013 |
|
Neoplasms
|
0.400 |
Biomarker
|
group |
BEFREE |
We found that inhibition or silencing of GCH1 reduced tumor cell proliferation and survival and the tube formation of human umbilical vein endothelial cells, which upon hypoxia increased GCH1 and endothelial NOS expression, the latter prevented by inhibition of GCH1.
|
22753274 |
2013 |
|
Neoplasms
|
0.400 |
Biomarker
|
group |
BEFREE |
To explore the role of nuclear eNOS in the acquisition of aggressive phenotype in PCa, we performed ChIP-Sequencing on chromatin-associated eNOS from cells from a primary tumor with poor outcome and from metastatic LNCaP cells.
|
23658738 |
2013 |
|
Neoplasms
|
0.400 |
AlteredExpression
|
group |
BEFREE |
Quantitative RT-PCR analysis revealed an increase of VEGF, VEGFR1 and 2, PDGF-A, PDGF-B, and eNOS expression in tumor versus normal tissues.
|
22815044 |
2013 |
|
Neoplasms
|
0.400 |
GeneticVariation
|
group |
BEFREE |
The increased frequency of NOS3 Glu298Asp homozygotes genotypes in patients who had advanced tumour stage was statistically significant (P = 0.042).
|
21706163 |
2012 |
|
Neoplasms
|
0.400 |
Biomarker
|
group |
BEFREE |
Endoglin heterozygote mice develop HHT-like vascular abnormalities, have impaired tumor and post-ischemic angiogenesis and demonstrate an endothelial nitric oxide synthase-dependent deterioration in the regulation of vascular tone.
|
18283546 |
2008 |
|
Neoplasms
|
0.400 |
Biomarker
|
group |
BEFREE |
The NOS3 transcript levels presented a bimodal behavior in tumor development and may be used as a biomarker together with the PCA3 marker for molecular staging of the prostate cancer.
|
18823560 |
2008 |
|
Neoplasms
|
0.400 |
Biomarker
|
group |
CTD_human |
Here we show that blocking phosphorylation of the AKT substrate, endothelial nitric oxide synthase (eNOS or NOS3), inhibits tumour initiation and maintenance.
|
18344980 |
2008 |
|
Neoplasms
|
0.400 |
Biomarker
|
group |
BEFREE |
However, the angiogenic effect of endothelial nitric oxide synthase on infarcted myocardium and the role of tumor growth factor beta1 signaling in cardiac remodeling mediated by endothelial nitric oxide synthase/nitric oxide have not yet been elucidated.
|
17637430 |
2007 |
|
Neoplasms
|
0.400 |
GeneticVariation
|
group |
BEFREE |
The present study aimed at evaluating the ecNOS Glu-298-Asp polymorphism by the PCR-RFLP technique, associating genotypes with gene expression levels and the tumor biomarker, Prostate Cancer Antigen (DD3), through semi-quantitative RT-PCR.
|
16458450 |
2006 |
|
Neoplasms
|
0.400 |
Biomarker
|
group |
BEFREE |
Three genes, NOS3, alpha-actinin-2 and alpha-catenin, suspected of playing a role in tumor genesis, were explored by quantitative RT-PCR analysis and immunohistochemistry.
|
15806164 |
2005 |
|
Neoplasms
|
0.400 |
Biomarker
|
group |
BEFREE |
In this study, we examined whether the modulation of the stoichiometry of the caveolin/eNOS complex in EC lining tumor blood vessels could affect the tumor vasculature and consecutively tumor growth.
|
15623570 |
2005 |
|
Neoplasms
|
0.400 |
GeneticVariation
|
group |
BEFREE |
Within the vulvar cancer group, the presence of a polymorphic NOS3*A or a polymorphic NOS3 exon 7 Glu298Asp allele was not associated with clinico-pathological parameters such as advanced tumor stage, groin lymph node involvement, tumor grading, and age at diagnosis.
|
15196865 |
2004 |
|
Neoplasms
|
0.400 |
AlteredExpression
|
group |
BEFREE |
Taken together, these findings support the hypothesis that high expression of endothelial nitric oxide synthase in the tumor microenvironment might increase or be a marker for endothelial cells sensitivity to TNF.
|
15501965 |
2004 |
|
Neoplasms
|
0.400 |
Biomarker
|
group |
BEFREE |
Allelic variation within intron 4 of Nos3 is associated with an advanced tumor stage and positive lymph node involvement in ovarian cancer.
|
12144818 |
2002 |
|
Neoplasms
|
0.400 |
AlteredExpression
|
group |
BEFREE |
These results show significant effects of overexpression of eNOS on tumor growth in vitro and in vivo.
|
9543390 |
1998 |
|
Neoplasms
|
0.400 |
AlteredExpression
|
group |
BEFREE |
The expression of the endothelial NOS, neuronal NOS and inducible NOS in the tumor tissue was significantly lower than in normal gastric mucosa (P = 0.01, P = 0.02, P < 0.01, respectively).
|
9328184 |
1997 |