|
Vascular Diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
These results suggest that GLA deficiency promotes VWF secretion through eNOS dysregulation, which may contribute to the vasculopathy of Fabry disease.
|
30470436 |
2019 |
|
Vascular Diseases
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Structural uncoupling of eNOS, with generation of enzyme monomers, is thought to contribute to endothelial dysfunction in several vascular disorders, including aging.
|
30289292 |
2019 |
|
Vascular Diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
Liver injury leads to a vasculopathy in which post-translational modifications of endothelial nitric oxide synthase (eNOS) lead to impaired nitric oxide synthesis.
|
28162981 |
2017 |
|
Vascular Diseases
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Endothelial nitric oxide synthase gene intron 4 VNTR polymorphism in sickle cell disease: relation to vasculopathy and disease severity.
|
25263931 |
2015 |
|
Vascular Diseases
|
0.100 |
GeneticVariation
|
group |
BEFREE |
The endothelial nitric oxide synthase (eNOS) gene single nucleotide polymorphism G894T is associated with thrombotic vascular diseases.
|
25917853 |
2015 |
|
Vascular Diseases
|
0.100 |
AlteredExpression
|
group |
BEFREE |
These findings indicate that at least M1 macrophage-mediated expression of MMP-13 in NOS3 null mice induces neointima formation after vascular injury, suggesting that MMP-13 may represent a new promising target in vascular disease.
|
24925976 |
2014 |
|
Vascular Diseases
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Nitric oxide levels and NOS3 gene variants play a pivotal role in the development of vascular diseases/stroke.
|
24986538 |
2014 |
|
Vascular Diseases
|
0.100 |
GeneticVariation
|
group |
BEFREE |
The 894TT genotype of 894G>T (rs1799983" genes_norm="4846">Glu298Asp, rs1799983), a polymorphic variant of eNOS, has been associated with several vascular diseases.
|
23512673 |
2013 |
|
Vascular Diseases
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Induction of endothelial nitric oxide synthase expression by IL-17 in human vascular endothelial cells: implications for vascular remodeling in transplant vasculopathy.
|
22219320 |
2012 |
|
Vascular Diseases
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Endothelial nitric oxide synthase (eNOS) G894T polymorphism has been previously associated with vascular diseases including stroke, but often with conflicting results.
|
22004707 |
2011 |
|
Vascular Diseases
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Genetic polymorphisms in the endothelial nitric oxide synthase (eNOS) and nicotinamide adenosine dinucleotide phosphate (NADPH) oxidase p22phox are linked with the expression and/or progression of vascular disease.
|
19965945 |
2010 |
|
Vascular Diseases
|
0.100 |
GeneticVariation
|
group |
BEFREE |
The eNOS gene polymorphism at position 894 (G>T, Glu298Asp) resulting in T allele has been studied in the context of vascular diseases, but its role in sepsis has not yet been explored.
|
18827745 |
2009 |
|
Vascular Diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
These results indicated that the etiology of vascular disease in ESRD patients is associated with ACE and eNOS (G894 --> T) gene polymorphisms.
|
18629615 |
2008 |
|
Vascular Diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
Genetic variation in GCH1 underlies important differences in endogenous BH4 availability and is a determinant of eNOS coupling, vascular redox state, and endothelial function in human vascular disease.
|
18598896 |
2008 |
|
Vascular Diseases
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Mechanisms of vasculopathy in sickle mice involve global dysregulation of the NO axis: impaired constitutive nitric oxide synthase activity (NOS) with loss of endothelial NOS (eNOS) dimerization, increased NO scavenging by plasma hemoglobin and superoxide, increased arginase activity, and depleted intravascular nitrite reserves.
|
17158223 |
2007 |
|
Vascular Diseases
|
0.100 |
GeneticVariation
|
group |
BEFREE |
The association between the endothelial nitric oxide synthase (eNOS) gene with vascular diseases in Western populations and with severe preeclampsia (PE) in the Japanese population have been demonstrated, lacing the data in Chinese population.
|
17636229 |
2007 |
|
Vascular Diseases
|
0.100 |
GeneticVariation
|
group |
BEFREE |
The endothelial nitric oxide synthase (eNOS) gene harbors three well-characterized genetic variants, which have been reported to be associated with various vascular diseases.
|
16467782 |
2006 |
|
Vascular Diseases
|
0.100 |
AlteredExpression
|
group |
BEFREE |
This communication reviews the role of eNOS in erectile physiology and discusses the alterations in eNOS expression in various vascular diseases of the penis.
|
16378511 |
2005 |
|
Vascular Diseases
|
0.100 |
Biomarker
|
group |
LHGDN |
Kruppel-like factor 2 as a novel mediator of statin effects in endothelial cells.
|
16043642 |
2005 |
|
Vascular Diseases
|
0.100 |
GeneticVariation
|
group |
BEFREE |
The Glu298Asp (G894T) polymorphic variant of eNOS has been associated with vascular disease, but functional data are lacking.
|
11298374 |
2001 |
|
Vascular Diseases
|
0.100 |
AlteredExpression
|
group |
BEFREE |
This fact may be important for the development of atherosclerotic lesions during chronic renal failure and is in accordance with recently published studies showing that under conditions with decreased constitutive NOS activity, iNOS might substitute the synthesis of NO. iNOS expression in vascular smooth muscle cells and macrophages is supposed to prevent restenosis following angioplasty or heart transplant vasculopathy.
|
11168974 |
2001 |
|
Vascular Diseases
|
0.100 |
GeneticVariation
|
group |
BEFREE |
This paper reviews the current status of functional significance for reported sequence variations in the eNOS gene and the relevance of these variants to different forms of vascular diseases.
|
10993711 |
2000 |