NOS3, nitric oxide synthase 3, 4846

N. diseases: 706; N. variants: 39
Disease: Antiphospholipid Syndrome ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0085278
Disease: Antiphospholipid Syndrome
Antiphospholipid Syndrome 		0.010 GeneticVariation disease BEFREE In the antiphospholipid syndrome (APS), antiphospholipid antibody (aPL) recognition of β2 glycoprotein I promotes thrombosis, and preclinical studies indicate that this is due to endothelial nitric oxide synthase (eNOS) antagonism via apolipoprotein E receptor 2 (apoER2)-dependent processes. 29500169 2018