NOS3, nitric oxide synthase 3, 4846

N. diseases: 706; N. variants: 39
Disease: High altitude pulmonary edema ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0340100
Disease: High altitude pulmonary edema
High altitude pulmonary edema 		0.070 GeneticVariation disease BEFREE Meta-analysis showed overall association of NOS3 G894T SNP with HAPE risk under the allele contrast and dominant genetic models, which remained significant for Asians. 23603420 2013
CUI: C0340100
Disease: High altitude pulmonary edema
High altitude pulmonary edema 		0.070 GeneticVariation disease BEFREE There were no significant differences between carriers of the eNOS 894G and 894T polymorphism alleles in terms of the risk of developing HAPE. 22795910 2012
CUI: C0340100
Disease: High altitude pulmonary edema
High altitude pulmonary edema 		0.070 GeneticVariation disease BEFREE Several laboratories, including ours, have shown that variants in NOS3 (the gene encoding eNOS) are overrepresented in individuals with altitude-related illnesses such as high altitude pulmonary edema (HAPE) and acute mountain sickness (AMS), suggesting that NOS3 genotypes contribute to altitude tolerance. 20367485 2010
CUI: C0340100
Disease: High altitude pulmonary edema
High altitude pulmonary edema 		0.070 GeneticVariation disease BEFREE Previous genetic association studies in high-risk subjects have suggested that polymorphisms in the gene encoding endothelial nitric oxide synthase (eNOS) may be associated with susceptibility to high altitude pulmonary edema (HAPE). 16978134 2006
CUI: C0340100
Disease: High altitude pulmonary edema
High altitude pulmonary edema 		0.070 GeneticVariation disease BEFREE In the present study, we investigated G894T, 27-base-pair 4b/4a (variable number of tandem repeat), -922A/G, and -786T/C polymorphisms of NOS3, individually or in combination, for an association with HAPE. 17099031 2006
CUI: C0340100
Disease: High altitude pulmonary edema
High altitude pulmonary edema 		0.070 GeneticVariation disease BEFREE Haplotype analysis for the NOS3 polymorphisms also revealed no association with HAPE. 14561241 2003
CUI: C0340100
Disease: High altitude pulmonary edema
High altitude pulmonary edema 		0.070 GeneticVariation disease BEFREE Both polymorphisms of the eNOS gene were significantly associated with HAPE. 12176955 2002