|
Chronic kidney disease stage 5
|
0.300 |
GeneticVariation
|
disease |
BEFREE |
Variants of eNOS gene might play different roles in the ESRD progression in ADPKD.
|
24995932 |
2014 |
|
Chronic kidney disease stage 5
|
0.300 |
GeneticVariation
|
disease |
BEFREE |
Sixteen articles were identified for the analysis of association between eNOS gene polymorphisms and ESRD risk.
|
24673298 |
2014 |
|
Chronic kidney disease stage 5
|
0.300 |
GeneticVariation
|
disease |
BEFREE |
However, a link between eNOS Glu298Asp gene polymorphism and ESRD risk was not found in Caucasians and Brazil population.
|
23464568 |
2013 |
|
Chronic kidney disease stage 5
|
0.300 |
GeneticVariation
|
disease |
BEFREE |
Four polymorphisms showed association with ESRD: rs1801275 in the interleukin 4 receptor (IL4R) gene (OR: 0.66 (95%CI = 0.46-0.95); p = 0.025; overdominant model), rs4586 in chemokine (C-C motif) ligand 2 (CCL2) gene (OR: 0.70 (95%CI = 0.54-0.90); p = 0.005; additive model), rs301640 located in an intergenic binding site for signal transducer and activator of transcription 4 (STAT4) (OR: 1.82 (95%CI = 1.17-2.83); p = 0.006; additive model) and rs7830 in the nitric oxide synthase 3 (NOS3) gene (OR: 1.31 (95%CI = 1.01-1.71); p = 0.043; additive model).
|
22817530 |
2012 |
|
Chronic kidney disease stage 5
|
0.300 |
Biomarker
|
disease |
BEFREE |
Overall these findings form preliminary evidence that disturbed interaction between CAV-1 and eNOS may be of relevance for arterial disease in ESRD and perhaps in other human diseases.
|
21976276 |
2012 |
|
Chronic kidney disease stage 5
|
0.300 |
GeneticVariation
|
disease |
BEFREE |
This suggests that the ecNOS gene polymorphism may be associated with an increased risk of chronic renal failure.
|
21519233 |
2011 |
|
Chronic kidney disease stage 5
|
0.300 |
GeneticVariation
|
disease |
BEFREE |
However, larger future prospective studies are required to confirm the role of eNOS gene polymorphism in the progression of diabetic nephropathy to ESRD.
|
21854353 |
2011 |
|
Chronic kidney disease stage 5
|
0.300 |
Biomarker
|
disease |
RGD |
Oral sorbent AST-120 increases renal NO synthesis in uremic rats.
|
18089446 |
2008 |
|
Chronic kidney disease stage 5
|
0.300 |
GeneticVariation
|
disease |
BEFREE |
The aim of the present study was to examine the Glu298Asp polymorphism of endothelial nitric oxide synthase (eNOS) in patients with end-stage renal disease (ESRD).
|
18793530 |
2008 |
|
Chronic kidney disease stage 5
|
0.300 |
GeneticVariation
|
disease |
BEFREE |
Our data also suggest that an interaction effect may exist between ACE (I/D) and eNOS (G894 --> T) polymorphism in increasing the risk of vascular complications in ESRD patients.
|
18629615 |
2008 |
|
Chronic kidney disease stage 5
|
0.300 |
GeneticVariation
|
disease |
BEFREE |
The distribution of C/T alleIes is significantly different between rapid and slow ADPKD progressors leading to the conclusion that the T allele of the Glu298Asp polymorphism of NOS3 gene is associated with earlier progression to ESRD in ADPKD patients.
|
18815450 |
2008 |
|
Chronic kidney disease stage 5
|
0.300 |
GeneticVariation
|
disease |
BEFREE |
The aim of this study was to investigate the presence of eNOS gene intron 4 polymorphism in patients with end-stage renal disease (ESRD).
|
17498125 |
2007 |
|
Chronic kidney disease stage 5
|
0.300 |
GeneticVariation
|
disease |
BEFREE |
The results disclosed that the ACE polymorphism had a slight influence on the age of onset of ESRD in ADPKD patients and the NOS3 and BDKBR1 polymorphisms showed a very slight involvement in renal outcome.
|
17303584 |
2007 |
|
Chronic kidney disease stage 5
|
0.300 |
GeneticVariation
|
disease |
BEFREE |
However, eNOS genotype showed a significant association with cardiovascular mortality in statistical models, including traditional risk factors and factors peculiar to ESRD, and became even stronger when plasma ADMA was forced into the Cox model (P=0.006).
|
16148605 |
2005 |
|
Chronic kidney disease stage 5
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
A time-dependent decrease in eNOS protein levels was evident in cultures treated with erythrocytes from ESRD patients.
|
15840037 |
2005 |
|
Chronic kidney disease stage 5
|
0.300 |
GeneticVariation
|
disease |
BEFREE |
Atherosclerosis and the Glu298Asp polymorphism of the eNOS gene in white patients with end-stage renal disease.
|
16364824 |
2005 |
|
Chronic kidney disease stage 5
|
0.300 |
GeneticVariation
|
disease |
BEFREE |
This work indicates that NOS3-4 polymorphism does not show any association with the development of ESRD in this studied European population.
|
15727257 |
2004 |
|
Chronic kidney disease stage 5
|
0.300 |
GeneticVariation
|
disease |
BEFREE |
The endothelial nitric oxide synthase Glu298Asp and Asp29Asp genotypes were significantly more frequent in rapid progressors (9.6% (7/73) Asp/Asp, 39.7% (29/73) Asp/Glu, 50.7% (37/73) Glu/Glu) and in ADPKD group with ESRF between 40-63 years (11.3% (16/142) Asp/Asp, 41.5% (59/142) Asp/Glu, 47.2% (67/142) Glu/Glu) in comparison with slow progressors (8.8% (8/91) Asp/Asp, 24.2% (22/91) Asp/Glu, 67.0% (61/91) Glu/Glu) and with control group (8% Asp/Asp, 32% Asp/Glu, 60% Glu/Glu) (Chi-square test, p<0.05).
|
15287194 |
2004 |
|
Chronic kidney disease stage 5
|
0.300 |
GeneticVariation
|
disease |
BEFREE |
This suggests that the ecNOS gene polymorphism may be associated with an increased risk of chronic renal failure.
|
15299097 |
2004 |
|
Chronic kidney disease stage 5
|
0.300 |
GeneticVariation
|
disease |
BEFREE |
Both in ADPKD and IGAN groups, there was no significant difference in the frequencies of ecNOS genotypes between patients with normal renal function and age matched patients with ESRF and between patients with normal renal function and control group.
|
12380903 |
2002 |
|
Chronic kidney disease stage 5
|
0.300 |
GeneticVariation
|
disease |
BEFREE |
The a allele of the ecNOS gene polymorphism showed a significantly higher incidence among patients with ESRF caused by ADPKD.
|
12077489 |
2002 |
|
Chronic kidney disease stage 5
|
0.300 |
GeneticVariation
|
disease |
BEFREE |
The frequency of ecNOS a allele was significantly higher in a number limited group ADPKD patients with ESRF later than in 62 years (Chi-square test p < 0.05).
|
12212826 |
2002 |
|
Chronic kidney disease stage 5
|
0.300 |
GeneticVariation
|
disease |
BEFREE |
In conclusion, the frequent Glu298Asp polymorphism of ENOS is associated with a 5 year lower mean age at ESRD in this subset of ADPKD males.
|
11823442 |
2002 |
|
Chronic kidney disease stage 5
|
0.300 |
Biomarker
|
disease |
BEFREE |
We investigated whether polymorphism of intron 4 of the endothelial constitutive nitric oxide synthase (ecNOS) gene is related to the progression of chronic renal failure.
|
11549906 |
2001 |
|
Chronic kidney disease stage 5
|
0.300 |
GeneticVariation
|
disease |
BEFREE |
We investigated the relationship between endothelial constitutive nitric oxide synthase (ecNOS) gene polymorphism and lipid metabolism in patients with nondiabetic chronic renal failure on hemodialysis.
|
11340349 |
2001 |