|
Adenocarcinoma
|
0.090 |
AlteredExpression
|
group |
BEFREE |
We found that mRNA high expression level of Notch1 was associated with better overall survival (OS) for all NSCLC patients, hazard ratio (HR) 0.78 (0.69-0.89), p=0.00019, better OS in adenocarcinoma (Ade) patients, HR 0.59 (0.46-0.75), p=1.5e-05, as well as in squamous cell carcinoma (SCC) patients, HR 0.78 (0.62-0.99), p=0.044. mRNA high expression levels of Notch2 and Notch3 were associated with worsen OS for all NSCLC patients, as well as in Ade, but not in SCC patients. mRNA high expression level of Notch4 was not found to be associated with to OS for all NSCLC patients.
|
28061457 |
2017 |
|
Adenocarcinoma
|
0.090 |
Biomarker
|
group |
BEFREE |
Other notable GAs include TP53 in >45% of each histotype; NOTCH1: adenocarcinoma, NOS (7.7%), ca ex PA (8.3%), carcinoma, NOS (21.6%); NF1: adenocarcinoma, NOS (9.6%), SDC (17.1%), carcinoma, NOS (18.8%).
|
27334835 |
2016 |
|
Adenocarcinoma
|
0.090 |
AlteredExpression
|
group |
BEFREE |
We used small interfering RNA (siRNA) technology to down-regulate the expression of Notch1 in small cell lung carcinoma (SCLC) cells; H69AR and SBC-3, as well as in non-small cell lung carcinoma (NSCLC) cells; A549 adenocarcinoma (ADC) and H2170 squamous cell carcinoma (SCC).
|
24888228 |
2014 |
|
Adenocarcinoma
|
0.090 |
Biomarker
|
group |
BEFREE |
Using mice engineered to coexpress activated Notch1 and Myc, we found that supplementing Myc expression resulted in increased frequency of Notch1 intracellular domain (N1ICD)-induced adenoma formation and enabled progression to adenocarcinoma and metastases.
|
21803744 |
2011 |
|
Adenocarcinoma
|
0.090 |
AlteredExpression
|
group |
BEFREE |
Strikingly, the expression level of Notch-1 pathway components was critical, because exosomal nanoparticles decreased the proliferation of cells in which these partners are either weakly represented, in differentiated adenocarcinoma cells, or inhibited, in poorly differentiated carcinoma cells, by blocking presenilin in the gamma-secretase complex that regulates the Notch-1 pathway.
|
19405120 |
2009 |
|
Adenocarcinoma
|
0.090 |
AlteredExpression
|
group |
BEFREE |
Furthermore, expression of Notch1 and its effector Hey-1 gene in human prostate adenocarcinomas were found significantly down-regulated compared to normal control tissues.
|
16360140 |
2006 |
|
Adenocarcinoma
|
0.090 |
Biomarker
|
group |
BEFREE |
In these animals, mouse mammary tumor virus LTR-driven expression of the constitutively active intracellular domain of the Notch1 receptor (N1(IC)) causes development of lactation-dependent mammary tumors that regress upon gland involution but progress to nonregressing, invasive adenocarcinomas in subsequent pregnancies.
|
16751266 |
2006 |
|
Adenocarcinoma
|
0.090 |
AlteredExpression
|
group |
LHGDN |
Quantitative PCR revealed decreased Notch 1 mRNA in ovarian adenocarcinomas compared with adenomas.
|
16136053 |
2005 |
|
Adenocarcinoma
|
0.090 |
AlteredExpression
|
group |
BEFREE |
Quantitative PCR revealed decreased Notch 1 mRNA in ovarian adenocarcinomas compared with adenomas.
|
16136053 |
2005 |
|
Adenocarcinoma
|
0.090 |
AlteredExpression
|
group |
BEFREE |
Examination of the transgenic adenocarcinoma of the mouse prostate showed that expression of Notch1 was elevated in malignant prostatic epithelial cells of primary and metastatic tumors.
|
11585768 |
2001 |