NOTCH1, notch receptor 1, 4851

N. diseases: 693; N. variants: 64
Disease: Thyroid carcinoma ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0549473
Disease: Thyroid carcinoma
Thyroid carcinoma 		0.060 AlteredExpression disease BEFREE Expression of NOTCH1 in thyroid cancer is mostly restricted to papillary carcinoma. 31265994 2019
CUI: C0549473
Disease: Thyroid carcinoma
Thyroid carcinoma 		0.060 AlteredExpression disease BEFREE We demonstrated that DEC1 controls NOTCH1 expression and that the interplay with the NOTCH pathway is relevant for DEC1 function in thyroid cancer. 30158530 2018
CUI: C0549473
Disease: Thyroid carcinoma
Thyroid carcinoma 		0.060 Biomarker disease BEFREE Here we have explored whether EBNA2 activates NOTCH1 targets in thyroid cancer lines and examined its effect on cellular proliferation. 27847111 2017
CUI: C0549473
Disease: Thyroid carcinoma
Thyroid carcinoma 		0.060 AlteredExpression disease BEFREE Recent evidence suggests that the Notch1 pathway is important in the regulation of thyroid cancer cell growth and expression of thyrocyte differentiation markers. 23594881 2013
CUI: C0549473
Disease: Thyroid carcinoma
Thyroid carcinoma 		0.060 Biomarker disease BEFREE Our findings provide the first documentation of the role of Notch1 signaling as a tumor suppressor in DRO and FTC236 cells, suggesting that Notch1 activation may be a potential therapeutic target for papillary and follicular thyroid cancers. 19190121 2009
CUI: C0549473
Disease: Thyroid carcinoma
Thyroid carcinoma 		0.060 AlteredExpression disease BEFREE Overexpression of Notch-1 in thyroid cancer cells restores differentiation, reduces cell growth rates, and stimulates NIS expression via a direct action on the NIS promoter. 18664540 2008