Leukemogenesis
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
These results indicate that PRC1.1 plays a key role in restricting excessive transcriptional activation by active NOTCH1, thereby acting as a tumor suppressor in the initiation of T-cell leukemogenesis.
|
31471323 |
2019 |
Leukemogenesis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Using loss-of-function approaches, we show that Il7r-deficient, but not wild-type, mouse hematopoietic progenitors transduced with constitutively active Notch1 failed to generate leukemia upon transplantation into immunodeficient mice, thus providing formal evidence that IL-7R function is essential for Notch1-induced T-cell leukemogenesis.
|
31530562 |
2019 |
Leukemogenesis
|
0.100 |
Biomarker
|
disease |
BEFREE |
We herein report a mechanism of NOTCH1-SHQ1-MYC axis in T-cell leukemogenesis.
|
30323192 |
2018 |
Leukemogenesis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Here, using the TEL-JAK2 transgenic (TJ2-Tg) mouse model of T-ALL/LBL, which is driven by constitutive JAK/STAT signaling and characterized by the acquisition of Notch1 mutations, we sought to identify stromal cell alterations associated with thymic leukemogenesis.
|
30256907 |
2018 |
Leukemogenesis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Stabilization of Notch1 by the Hsp90 Chaperone Is Crucial for T-Cell Leukemogenesis.
|
28143869 |
2017 |
Leukemogenesis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Yet the molecular events downstream of NOTCH1 that drive T-cell leukemogenesis remain incompletely understood.
|
27593934 |
2017 |
Leukemogenesis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Here we identify Hairy and Enhancer of Split 1 (HES1), a transcriptional repressor controlled by NOTCH1, as a critical mediator of NOTCH1-induced leukemogenesis strictly required for tumor cell survival.
|
25784680 |
2015 |
Leukemogenesis
|
0.100 |
Biomarker
|
disease |
BEFREE |
These results indicate that Notch1 signaling in HSCs promotes CD8(+) SP T cell development, and that T cell leukemogenesis may require additional oncogenic factors other than Notch1 activation.
|
24726647 |
2014 |
Leukemogenesis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Active mutations of Notch1 play pivotal roles during leukemogenesis, but the downstream targets and molecular mechanisms of activated Notch1 signaling have not yet been fully clarified.
|
23229232 |
2013 |
Leukemogenesis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
In conclusion, cooperation between aberrant expression of RasGRP1, a strong activator of Ras, and secondary gain-of-function mutations of NOTCH1 have an important role in T-cell leukemogenesis.
|
22116551 |
2012 |
Leukemogenesis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Pharmacologic inhibition of Notch signaling in these cells using γ-secretase inhibitors significantly delayed leukemogenesis in vivo. shRNA targeting of Notch1, as well as c-promoter-binding factor 1 (CBF1) and mastermind-like 1 (MAML1), 2 essential cofactors involved in transcriptional activation of Notch target genes, also significantly delayed or inhibited tumorigenesis in vivo.
|
21527531 |
2011 |
Leukemogenesis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Indeed, iron-deficient mice developed Notch1-induced T-ALL substantially more slowly than control mice, further supporting a critical role for iron uptake during leukemogenesis.
|
20516639 |
2010 |
Leukemogenesis
|
0.100 |
Biomarker
|
disease |
BEFREE |
In agreement with in vitro studies using human primary effusion lymphoma cell lines, we have found that Notch1 was expressed in the majority of HHV-8-positive primary effusion lymphoma cases, corroborating the notion that Notch1 may have an important role in HHV-8-mediated lymphomagenesis of primary effusion lymphoma.
|
20348880 |
2010 |
Leukemogenesis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Later events in murine Notch1-mediated leukemogenesis included down-regulation of genes encoding tumor suppressors and negative cell cycle regulators.
|
20007543 |
2010 |
Leukemogenesis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Together, these studies identify a genetic pathway involving Ikzf1, Kras(G12D), and Notch1 in T lineage leukemogenesis, reveal unexpected diversity in Ras-regulated signaling networks, and define biomarkers of drug responses that may inform treatment strategies.
|
20194733 |
2010 |
Leukemogenesis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The presence of the NOTCH1 activating mutation in MNKL might suggest a possible role in the leukemogenesis of MNKL.
|
20730882 |
2010 |
Leukemogenesis
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
We therefore speculated that down-regulation of Notch-1 expression might be involved in the leukemogenesis of acute myeloid leukemia (AML).
|
18497996 |
2008 |
Leukemogenesis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Collectively, these data show that mutation of hCDC4 is a frequent event in T-ALL and suggest that hCDC4 mutations and gain-of-function mutations in NOTCH1 might synergize in contributing to the development of pediatric T-ALL leukemogenesis.
|
17575125 |
2007 |
Leukemogenesis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
These results suggest that Notch-1 mutations can sometimes be acquired as secondary events in leukemogenesis and must be used cautiously as solitary minimal residual disease markers.
|
18056171 |
2007 |
Leukemogenesis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Although NOTCH1 mutation occurs infrequently in mature T-cell leukemia/lymphoma, NOTCH1 may be involved in leukemogenesis associated with various forms of T-cell leukemia/lymphoma rather than only with T-ALL.
|
17483057 |
2007 |
Leukemogenesis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
NOTCH1 mutations in T-cell acute lymphoblastic leukemia: prognostic significance and implication in multifactorial leukemogenesis.
|
16707600 |
2006 |
Leukemogenesis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Notch1-dependent lymphomagenesis is assisted by but does not essentially require pre-TCR signaling.
|
16507772 |
2006 |
Leukemogenesis
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
AML primary samples show high levels of JAGGED1 expression despite the low NOTCH1 pathway activation, consistent with an autonomous JAGGED1 signaling in myeloid leukemogenesis.
|
15694671 |
2005 |
Leukemogenesis
|
0.100 |
Biomarker
|
disease |
BEFREE |
As Notch1 gene is involved in the differentiation and leukemogenesis in lymphoid neoplasm, observations suggest that Notch1 is involved in ATRA-modulated differentiation process in APL.
|
15058751 |
2004 |