Post-Traumatic Stress Disorder
|
0.100 |
Biomarker
|
disease |
BEFREE |
Neuropeptide Y and cannabinoids interaction in the amygdala after exposure to shock and reminders model of PTSD.
|
31622603 |
2020 |
Post-Traumatic Stress Disorder
|
0.100 |
Biomarker
|
disease |
BEFREE |
Reduced levels of NPY are reported in Post-Traumatic Stress Disorder (PTSD) patients, and NPY has been proposed as a potential therapeutic target for PTSD.
|
31708112 |
2020 |
Post-Traumatic Stress Disorder
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Several promising genes, such as the COMT (catechol-O-methyltransferase) gene, the serotonin transporter gene (SLC6A4), and neuropeptide Y (NPY) suggest gene × environment interaction between genetic variants, childhood adversity, and the occurrence of PTSD and MDD, indicating an impact of these genes on resilience.
|
31583809 |
2020 |
Post-Traumatic Stress Disorder
|
0.100 |
Biomarker
|
disease |
BEFREE |
Intranasal neuropeptide Y (NPY) administration was shown to prevent hyperarousal in single prolonged stress (SPS) rodent PTSD model.
|
31250475 |
2019 |
Post-Traumatic Stress Disorder
|
0.100 |
Biomarker
|
disease |
BEFREE |
The aim of this study was to investigate the association between NPY and BDNF and PTSD in individuals who experienced war-related trauma in the South Eastern Europe (SEE) conflicts (1991-1999).
|
31291230 |
2019 |
Post-Traumatic Stress Disorder
|
0.100 |
Biomarker
|
disease |
BEFREE |
The results indicate that while SPS could be an appropriate PTSD model for females, sex differences, such as response to NPY, are important to consider.
|
30804766 |
2019 |
Post-Traumatic Stress Disorder
|
0.100 |
Biomarker
|
disease |
BEFREE |
Neuropeptide Y is a peptide neuromodulator with protective roles including anxiolytic and antidepressant-like effects in animal models of depression and post-traumatic stress disorder.
|
31082535 |
2019 |
Post-Traumatic Stress Disorder
|
0.100 |
Biomarker
|
disease |
BEFREE |
Additionally, other neuroendocrinological systems have been studied in PTSD including the use of oxytocin for PTSD prevention and augmentation to psychotherapy, allopregnanolone, and neuropeptide Y (NPY) for PTSD treatment.
|
30502374 |
2019 |
Post-Traumatic Stress Disorder
|
0.100 |
Biomarker
|
disease |
BEFREE |
We examined the tolerability and anxiolytic efficacy of neuropeptide Y administered via an intranasal route in patients with posttraumatic stress disorder.
|
29186416 |
2018 |
Post-Traumatic Stress Disorder
|
0.100 |
Biomarker
|
disease |
BEFREE |
Cardiovascular responses to intranasal neuropeptide Y in single prolonged stress rodent model of post-traumatic stress disorder.
|
29169656 |
2018 |
Post-Traumatic Stress Disorder
|
0.100 |
Biomarker
|
disease |
BEFREE |
Knowledge of shared underlying NPY system-related neurobiological factors that contribute to the comorbidity of PTSD and gastrointestinal disorders may help guide research, development and prescription of targeted and more effective individualized therapeutic interventions.
|
27898588 |
2017 |
Post-Traumatic Stress Disorder
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Neuropeptide Y (NPY) has robust anxiolytic properties, and its levels are reduced in patients with post-traumatic stress disorder.
|
28053027 |
2017 |
Post-Traumatic Stress Disorder
|
0.100 |
Biomarker
|
disease |
BEFREE |
In the current article, we review the evidence base for targeting the NPY system as a therapeutic approach in PTSD, and consider impediments and potential solutions to therapeutic development.
|
27913193 |
2017 |
Post-Traumatic Stress Disorder
|
0.100 |
Biomarker
|
disease |
BEFREE |
We also link specific symptoms of human PTSD with extant findings in the NPY field to reveal potential physiological contributions of the neuropeptide to the disorder.
|
22801411 |
2013 |
Post-Traumatic Stress Disorder
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The following review examines the biology of the NPY and neuroactive steroid systems as physiological links between metabolic syndrome and PTSD, a paradigmatic neuropsychiatric stress disorder.
|
20881319 |
2010 |
Post-Traumatic Stress Disorder
|
0.100 |
Biomarker
|
disease |
LHGDN |
NPY and extreme stress: lessons learned from posttraumatic stress disorder.
|
16383009 |
2006 |