NPY, neuropeptide Y, 4852

N. diseases: 243; N. variants: 8
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0525045
Disease: Mood Disorders
Mood Disorders
0.350 Biomarker group BEFREE Neuropeptide Y (NPY) has been associated with stress reactivity in affective disorders and is most densely expressed in the amygdala. 23482625 2014
CUI: C0525045
Disease: Mood Disorders
Mood Disorders
0.350 Biomarker group PSYGENET Neuropeptide Y (NPY) has been associated with stress reactivity in affective disorders and is most densely expressed in the amygdala. 23482625 2014
CUI: C0525045
Disease: Mood Disorders
Mood Disorders
0.350 Biomarker group BEFREE With this in mind, researchers suggested the involvement of NPY as well as the Y(1) and Y(2) receptors in affective disorders. 19782662 2010
CUI: C0525045
Disease: Mood Disorders
Mood Disorders
0.350 Biomarker group PSYGENET In this article, we review the literature from both animal and human studies regarding the contribution of NPY and its receptors in depression and stress. 19782662 2010
CUI: C0525045
Disease: Mood Disorders
Mood Disorders
0.350 Biomarker group PSYGENET Overall, although evident species differences were found in response to chronic psychosocial stress, the present study suggests a role for NPY receptors in the stress response and in the action of antidepressant drugs, providing further support for an involvement of this neuropeptidergic system in the pathophysiology of depression and anxiety. 19846047 2010
CUI: C0525045
Disease: Mood Disorders
Mood Disorders
0.350 Biomarker group PSYGENET Thus, anxiety- and depression-related behaviors were investigated in 2-yr-old NPY Y2 KO mice. 16691011 2007
CUI: C0525045
Disease: Mood Disorders
Mood Disorders
0.350 Biomarker group PSYGENET The data support our hypothesis that the NPY system dysregulation constitutes one of the biological underpinnings of depression and that one common mechanism of action of antidepressive treatment modalities may be effects on NPY and its receptors. 17572454 2007
CUI: C0525045
Disease: Mood Disorders
Mood Disorders
0.350 Biomarker group BEFREE For example, NPY is consistently involved in anxiety-related behaviors and there is increasing support for a role of this peptide in mood disorders such as depression. 16611091 2006
CUI: C0525045
Disease: Mood Disorders
Mood Disorders
0.350 Biomarker group BEFREE It has been hypothesized that the neuropeptide Y (NPY) system is involved in the pathogenesis of mood disorder. 11377922 2001
CUI: C0525045
Disease: Mood Disorders
Mood Disorders
0.350 GeneticVariation group BEFREE The restriction fragment length polymorphisms (RFLPs) associated with neuropeptide Y (NPY) and somatostatin loci were used to assess the possibility of linkage to a locus for affective disorder (AD). 2894462 1988