|
Neoplasms
|
0.020 |
AlteredExpression
|
group |
BEFREE |
NOVA2 and L1-ΔTM are overexpressed in the vasculature of ovarian cancer, where L1-ΔTM levels correlate with tumor vascularization, supporting the involvement of NOVA2-mediated L1-ΔTM production in tumor angiogenesis.
|
30829570 |
2019 |
|
Neoplasms
|
0.020 |
AlteredExpression
|
group |
BEFREE |
Our results provide, for the first time, evidence of NOVA2 expression and upregulation in tumor ECs and highlight hypoxia as a potential regulatory factor.
|
30275709 |
2018 |
|
Paraneoplastic Opsoclonus-Myoclonus Ataxia
|
0.020 |
Biomarker
|
disease |
BEFREE |
Nova-1 and Nova-2 are related neuronal proteins that were initially cloned using antisera obtained from patients with the autoimmune neurological disease paraneoplastic opsoclonus-myoclonus ataxia (POMA).
|
10368286 |
1999 |
|
Paraneoplastic Opsoclonus-Myoclonus Ataxia
|
0.020 |
Biomarker
|
disease |
BEFREE |
We have used POMA antisera to clone a cDNA encoding a second POMA disease antigen termed Nova-2.
|
9789075 |
1998 |
|
Glioma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Our data and bioinformatic analysis indicated the association of these molecules with glioma grade, a positive correlation between circ-U2AF1 and NOVA2 expression levels and a negative correlation of hsa-miR-7-5p with both circ-U2AF1 and NOVA2, respectively.
|
30341906 |
2019 |
|
cerebellar function
|
0.010 |
Biomarker
|
disease |
BEFREE |
Differential NOVA2-Mediated Splicing in Excitatory and Inhibitory Neurons Regulates Cortical Development and Cerebellar Function.
|
30638744 |
2019 |
|
Tumor Angiogenesis
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
NOVA2 and L1-ΔTM are overexpressed in the vasculature of ovarian cancer, where L1-ΔTM levels correlate with tumor vascularization, supporting the involvement of NOVA2-mediated L1-ΔTM production in tumor angiogenesis.
|
30829570 |
2019 |
|
tumor vasculature
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
These findings open a completely new perspective to study tumor vasculature and to uncover NOVA2 as a potential source of biomarkers and therapeutic targets based on AS isoforms.
|
30275709 |
2018 |
|
Malignant neoplasm of breast
|
0.010 |
Biomarker
|
disease |
BEFREE |
In repeated measurements ANOVA, general distress (GHQ-12, p = 0.01) and BC-specific distress (IES-bc, p = 0.03) were lower in DNA-direct than DNA-intake at all time measurements.
|
26531312 |
2016 |
|
Breast Carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
In repeated measurements ANOVA, general distress (GHQ-12, p = 0.01) and BC-specific distress (IES-bc, p = 0.03) were lower in DNA-direct than DNA-intake at all time measurements.
|
26531312 |
2016 |
|
Neuroblastoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Nova2 was only detected in neuroblastoma cells, suggesting a correlation between Nova2 expression and increased levels of Dab1-E-like splice forms in neuroblastoma.
|
22163036 |
2011 |
|
Retinoblastoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
As Nova2 has previously been implicated in the exclusion of exons 9B and 9C in Dab1, we examined the expression of this splicing factor in neuroblastoma and retinoblastoma cell lines.
|
22163036 |
2011 |
|
Central neuroblastoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Nova2 was only detected in neuroblastoma cells, suggesting a correlation between Nova2 expression and increased levels of Dab1-E-like splice forms in neuroblastoma.
|
22163036 |
2011 |
|
Childhood Neuroblastoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Nova2 was only detected in neuroblastoma cells, suggesting a correlation between Nova2 expression and increased levels of Dab1-E-like splice forms in neuroblastoma.
|
22163036 |
2011 |
|
nervous system disorder
|
0.010 |
Biomarker
|
group |
BEFREE |
Nova-1 and Nova-2 are related neuronal proteins that were initially cloned using antisera obtained from patients with the autoimmune neurological disease paraneoplastic opsoclonus-myoclonus ataxia (POMA).
|
10368286 |
1999 |
|
Cognition Disorders
|
0.010 |
AlteredExpression
|
group |
BEFREE |
The expression pattern of the Nova-2 protein is likely to underlie the development of cognitive deficits in some POMA patients.
|
9789075 |
1998 |
|
Impaired cognition
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
The expression pattern of the Nova-2 protein is likely to underlie the development of cognitive deficits in some POMA patients.
|
9789075 |
1998 |
|
Hypertensive disease
|
0.010 |
Biomarker
|
group |
BEFREE |
However, by two-way ANOVA, genetic risk for hypertension was an even more significant determinant (F = 7.84, P = .007) of compliance than blood pressure status (F = 2.69, P = .089).
|
8843884 |
1996 |