NPM1, nucleophosmin 1, 4869

N. diseases: 283; N. variants: 7
Disease: Endometrial Carcinoma ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0476089
Disease: Endometrial Carcinoma
Endometrial Carcinoma 		0.040 AlteredExpression disease BEFREE Immunohistochemistry revealed an overexpression of phospho-NPM/B23 (Thr199) in human endometrial cancer, and phospho-NPM/B23 (Thr199) expression levels were inversely associated with Erα in clinical specimen. 31330844 2019
CUI: C0476089
Disease: Endometrial Carcinoma
Endometrial Carcinoma 		0.040 AlteredExpression disease BEFREE More importantly, we also demonstrated that NPM1 was the target of miR-646, and HOTAIR promoted NPM1 expression through interacting with miR-646 in EC cells. 29466670 2018
CUI: C0476089
Disease: Endometrial Carcinoma
Endometrial Carcinoma 		0.040 AlteredExpression disease BEFREE Here, we demonstrate for the first time that nucleophosmin (NPM1/B23) suppression can restore the expression of estrogen receptor α (ESR1/ERα) in endometrial cancer cells. 27527851 2016
CUI: C0476089
Disease: Endometrial Carcinoma
Endometrial Carcinoma 		0.040 Biomarker disease BEFREE However, the regulatory role of NPM/B23 in estrogen signaling in endometrial cancer has not been explored. 22926011 2013