NPR1, natriuretic peptide receptor 1, 4881

N. diseases: 81; N. variants: 3
Disease: Hypertensive heart disease ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0152105
Disease: Hypertensive heart disease
Hypertensive heart disease 		0.020 Biomarker disease BEFREE The genetic disruption of Npr1 (encoding GC-A/NPRA) in mice exhibits high BP and hypertensive heart disease that is seen in untreated hypertensive subjects, including high BP and heart failure. 30169131 2018
CUI: C0152105
Disease: Hypertensive heart disease
Hypertensive heart disease 		0.020 Biomarker disease BEFREE We here report that mice lacking a functional Npr1 gene coding for NPRA have elevated blood pressures and hearts exhibiting marked hypertrophy with interstitial fibrosis resembling that seen in human hypertensive heart disease. 9405681 1997