Non-Small Cell Lung Carcinoma
|
0.460 |
AlteredExpression
|
disease |
BEFREE |
Research has revealed that microRNA (miR)‑4500 is downregulated in non‑small cell lung cancer (NSCLC), and miR‑4500 suppresses tumor growth by targeting lin‑28 homolog B and NRAS proto‑oncogene, GTPase.
|
31638206 |
2019 |
Non-Small Cell Lung Carcinoma
|
0.460 |
Biomarker
|
disease |
BEFREE |
In total 50 plasma samples from patients newly diagnosed with advanced NSCLC or resistant to first-line tyrosine kinase inhibitors (TKIs) were subjected to deep sequencing on a seven-gene panel (BRAF, EGFR, ERBB2, KRAS, NRAS, PIK3CA, PTEN) incorporated with molecular barcodes to improve accuracy in variant detection.
|
30268455 |
2018 |
Non-Small Cell Lung Carcinoma
|
0.460 |
Biomarker
|
disease |
BEFREE |
In this study, we assessed 179 clinical cases of non-small cell lung carcinoma (NSCLC) that had been previously tested for EGFR, KRAS, NRAS, and BRAF mutations using a novel multiplexed analytic approach that reduces wild-type signal and allows for detection of low mutation load approaching 1%, iPLEX® HS panel for the MassARRAY® System (Agena Bioscience, San Diego, CA).
|
28926605 |
2017 |
Non-Small Cell Lung Carcinoma
|
0.460 |
GeneticVariation
|
disease |
BEFREE |
We identified four (two NRAS and single AKT1 and PTEN) mutations in CNS metastases of NSCLC.
|
28097440 |
2017 |
Non-Small Cell Lung Carcinoma
|
0.460 |
GeneticVariation
|
disease |
CLINVAR |
Genetic mutation screen in early non--small-cell lung cancer (NSCLC) specimens.
|
24370118 |
2014 |
Non-Small Cell Lung Carcinoma
|
0.460 |
CausalMutation
|
disease |
CLINVAR |
Characteristics of lung cancers harboring NRAS mutations.
|
23515407 |
2013 |
Non-Small Cell Lung Carcinoma
|
0.460 |
GeneticVariation
|
disease |
BEFREE |
While 95% of patients were former or current smokers, smoking-related G:C>T:A transversions were significantly less frequent in NRAS-mutated lung tumors than KRAS-mutant non-small cell lung cancer [NSCLC; NRAS: 13% (4/30), KRAS: 66% (1772/2733), P < 0.00000001].
|
23515407 |
2013 |
Non-Small Cell Lung Carcinoma
|
0.460 |
CausalMutation
|
disease |
CLINVAR |
Lung cancers with acquired resistance to EGFR inhibitors occasionally harbor BRAF gene mutations but lack mutations in KRAS, NRAS, or MEK1.
|
22773810 |
2012 |
Non-Small Cell Lung Carcinoma
|
0.460 |
CausalMutation
|
disease |
CLINVAR |
Cytostatic activity of adenosine triphosphate-competitive kinase inhibitors in BRAF mutant thyroid carcinoma cells.
|
19880792 |
2010 |
Non-Small Cell Lung Carcinoma
|
0.460 |
CausalMutation
|
disease |
CLINVAR |
Frequency and distinctive spectrum of KRAS mutations in never smokers with lung adenocarcinoma.
|
18794081 |
2008 |
Non-Small Cell Lung Carcinoma
|
0.460 |
CausalMutation
|
disease |
CLINVAR |
Somatic mutations affect key pathways in lung adenocarcinoma.
|
18948947 |
2008 |
Non-Small Cell Lung Carcinoma
|
0.460 |
CausalMutation
|
disease |
CLINVAR |
BRAF mutations in papillary carcinomas of the thyroid.
|
14508525 |
2003 |
Non-Small Cell Lung Carcinoma
|
0.460 |
CausalMutation
|
disease |
CLINVAR |
BRAF and RAS mutations in human lung cancer and melanoma.
|
12460918 |
2002 |
Non-Small Cell Lung Carcinoma
|
0.460 |
Biomarker
|
disease |
BEFREE |
Alterations in 5 microsatellite loci were analyzed in tumors from 137 patients with primary non-small cell lung carcinomas that were also genotyped for the Hras1 variable number of tandem repeats (VNTR) locus.
|
7664270 |
1995 |
Non-Small Cell Lung Carcinoma
|
0.460 |
CausalMutation
|
disease |
CLINVAR |
ras gene mutations in non-small cell lung cancers are associated with shortened survival irrespective of treatment intent.
|
1654209 |
1991 |
Non-Small Cell Lung Carcinoma
|
0.460 |
CausalMutation
|
disease |
CLINVAR |
Mechanism of activation of an N-ras oncogene of SW-1271 human lung carcinoma cells.
|
6587382 |
1984 |
Non-Small Cell Lung Carcinoma
|
0.460 |
CausalMutation
|
disease |
CGI |
|
|
|