NRAS, NRAS proto-oncogene, GTPase, 4893

N. diseases: 611; N. variants: 17
Disease: Benign melanocytic nevus ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C1456781
Disease: Benign melanocytic nevus
Benign melanocytic nevus 		0.060 GeneticVariation disease BEFREE The expression of β-catenin, LEF-1, and HPA-1 was assessed and compared in malignant melanoma with that of peritumoral tissue and benign nevus in the patients with negative mutations in BRAF exons 11 and 15 and NRAS exons 1 and 2. 25343173 2015
CUI: C1456781
Disease: Benign melanocytic nevus
Benign melanocytic nevus 		0.060 GeneticVariation disease BEFREE In vitro, 1 in 250 cells from fresh lCMN formed colonies that could be passaged and harbored the same NRAS mutation as the original nevus. 25310409 2015
CUI: C1456781
Disease: Benign melanocytic nevus
Benign melanocytic nevus 		0.060 GeneticVariation disease BEFREE Focused amplicon deep sequencing on DNA extracted from the brain tumor and a cutaneous nevus revealed a heterozygous (c.37G>C; p.G13R) substitution in the NRAS gene. 25330907 2014
CUI: C1456781
Disease: Benign melanocytic nevus
Benign melanocytic nevus 		0.060 GeneticVariation disease BEFREE In this series the presence of a BRAF- or NRAS mutation in a nevus was not associated with the risk of malignant transformation. 23861977 2013
CUI: C1456781
Disease: Benign melanocytic nevus
Benign melanocytic nevus 		0.060 Biomarker disease BEFREE Our results suggest that although nevus propensity is important for the occurrence of both BRAF and NRAS-mutant melanomas, ambient UV irradiance influences risk differently based on the age of exposure. 17507627 2007
CUI: C1456781
Disease: Benign melanocytic nevus
Benign melanocytic nevus 		0.060 GeneticVariation disease BEFREE The predominant BRAF mutation T1799A (V600E) was detected in 18 nevi; 1 nevus had a novel A1781G (D594V) mutation in the same gene and 3 nevi had mutations in codon 61 of the N-ras gene. 15009715 2004