YBX1, Y-box binding protein 1, 4904

N. diseases: 148; N. variants: 1
Disease: Mammary Neoplasms ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C1458155
Disease: Mammary Neoplasms
Mammary Neoplasms 		0.340 Biomarker group BEFREE We conclude that YB-1 cooperates with p300 to allow BMI1 to over-ride p16(INK4a) -mediated cell cycle arrest enabling self-renewal and the development of aggressive breast tumors. 24648416 2014
CUI: C1458155
Disease: Mammary Neoplasms
Mammary Neoplasms 		0.340 AlteredExpression group BEFREE p53 Suppresses lung resistance-related protein expression through Y-box binding protein 1 in the MCF-7 breast tumor cell line. 21344396 2011
CUI: C1458155
Disease: Mammary Neoplasms
Mammary Neoplasms 		0.340 AlteredExpression group BEFREE Importantly, YB-1 is increased in tumor cell lines resistant to cisplatin, and the level of nuclear expression of YB-1 is predictive of drug resistance and patient outcome in breast tumors, ovarian cancers, and synovial sarcomas. 18307537 2008
CUI: C1458155
Disease: Mammary Neoplasms
Mammary Neoplasms 		0.340 AlteredExpression group LHGDN Akt phosphorylates the Y-box binding protein 1 at Ser102 located in the cold shock domain and affects the anchorage-independent growth of breast cancer cells. 15806160 2005
CUI: C1458155
Disease: Mammary Neoplasms
Mammary Neoplasms 		0.340 Biomarker group CTD_human We found that breast tumors which were both estrogen receptor-negative and lymph node positive were associated with high YB-1 expression (P=0.017). 15703814 2005