|
Abnormal behavior
|
0.040 |
Biomarker
|
phenotype |
BEFREE |
The tropomyosin-related kinase B (TrkB)/brain-derived neurotrophic factor system has been associated with psychiatric disorders, and animal models of defects in this system suggest that it might have a particular role in anxiety.
|
21126736 |
2011 |
|
Abnormal behavior
|
0.040 |
Biomarker
|
phenotype |
BEFREE |
BDNF-TrkB receptor regulation of distributed adult neural plasticity, memory formation, and psychiatric disorders.
|
24484701 |
2014 |
|
Abnormal behavior
|
0.040 |
GeneticVariation
|
phenotype |
BEFREE |
Administration of the trkB agonist 7,8-dihydroxyflavone (7,8-DHF) during adolescence at doses that stimulated ERK42/44 corrected long-lasting corticosterone-induced behavioral abnormalities.
|
29186135 |
2017 |
|
Abnormal behavior
|
0.040 |
Biomarker
|
phenotype |
BEFREE |
Our study demonstrates that genetic variability of NTRK2, a susceptibility gene for psychiatric disorders, is related to emotional arousal and-independently-to brain white-matter properties in healthy individuals.
|
26978740 |
2016 |
|
Abnormal corpus callosum morphology
|
0.100 |
Biomarker
|
phenotype |
HPO |
|
|
|
|
Abnormal myelination
|
0.100 |
Biomarker
|
phenotype |
HPO |
|
|
|
|
Abnormality of skin morphology
|
0.100 |
Biomarker
|
phenotype |
HPO |
|
|
|
|
Abnormality of vision
|
0.100 |
Biomarker
|
disease |
HPO |
|
|
|
|
Absent speech
|
0.100 |
Biomarker
|
phenotype |
HPO |
|
|
|
|
Addictive Behavior
|
0.020 |
Biomarker
|
phenotype |
BEFREE |
In application to a real dataset, we detected one significant tetragenic interaction among CHRNA4, CHRNB2, BDNF, and NTRK2 associated with nicotine dependence in the Study of Addiction: Genetics and Environment sample, suggesting the biological role of these genes in nicotine dependence development.
|
24057800 |
2014 |
|
Addictive Behavior
|
0.020 |
Biomarker
|
phenotype |
BEFREE |
Taken together, these results support a role for the NTRK2 gene in addiction in a Caucasian population with AD and a subtype of ASPD.
|
17200667 |
2007 |
|
Adenocarcinoma
|
0.010 |
AlteredExpression
|
group |
LHGDN |
The Trk tyrosine kinase inhibitor K252a regulates growth of lung adenocarcinomas.
|
16862449 |
2007 |
|
Adenocarcinoma of lung (disorder)
|
0.320 |
Biomarker
|
disease |
BEFREE |
Together, our results suggested that downregulated NTRK2 might be used in the diagnostic and prognostic evaluation of LUAD patients, or as a potential therapeutic target for the treatment of LUAD.
|
31245181 |
2019 |
|
Adenocarcinoma of lung (disorder)
|
0.320 |
GeneticVariation
|
disease |
UNIPROT |
|
|
|
|
Adenocarcinoma of lung (disorder)
|
0.320 |
GeneticVariation
|
disease |
BEFREE |
Another site, in the extracellular part of TRKB, is mutated in a human lung adenocarcinoma cell line (TRKB(L138F)).
|
21379385 |
2011 |
|
Adult Medulloblastoma
|
0.020 |
Biomarker
|
disease |
BEFREE |
Here, we show that the selective TrkB inhibitor N-[2-[[(hexahydro-2-oxo-1H-azepin-3-yl)amino]carbonyl]phenyl]-benzo[b]thiophene-2-carboxamide (ANA-12) markedly reduced the viability and survival of human cell lines representative of different MB molecular subgroups.
|
26614346 |
2016 |
|
Adult Medulloblastoma
|
0.020 |
Biomarker
|
disease |
BEFREE |
In the present study, we have examined the influence of brain-derived neurotrophic factor (BDNF)/TrkB receptor- and gastrin-releasing peptide receptor (GRPR)-mediated signaling on the viability of human medulloblastoma cells.
|
19642024 |
2010 |
|
Adult Pilocytic Astrocytoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Recurrent somatic alterations of FGFR1 and NTRK2 in pilocytic astrocytoma.
|
23817572 |
2013 |
|
Alcohol Related Birth Defect
|
0.300 |
Biomarker
|
disease |
PSYGENET |
Effects of prenatal alcohol exposure on brain-derived neurotrophic factor and its receptor tyrosine kinase B in offspring.
|
15854584 |
2005 |
|
Alcoholic Intoxication, Chronic
|
0.330 |
GeneticVariation
|
disease |
BEFREE |
The single-SNP analysis showed that the dominant minor allele of rs2134655 on DRD3 increases alcoholism susceptibility; the dominant minor allele of rs1439047 on NTRK2 delays the alcoholism onset age, but the additive minor allele of rs172677 on GRIN2B and the dominant minor allele of rs63319 on ALDH1A1 advance the alcoholism onset age; and the dominant minor allele of rs1079597 on DRD2 shortens the onset age range.
|
28512340 |
2017 |
|
Alcoholic Intoxication, Chronic
|
0.330 |
GeneticVariation
|
disease |
BEFREE |
Also, recent human genetic studies have supported a role of BDNF signaling in addictive behaviors by allele-, genotype-, and haplotype-based association of the TrkB gene, which encodes the cognate receptor for BDNF, with alcohol dependence.
|
18077569 |
2007 |
|
Alcoholic Intoxication, Chronic
|
0.330 |
GeneticVariation
|
disease |
BEFREE |
Individually, three SNPs were associated with alcohol dependence and alcohol abuse (AD) (P-value from 0.0019 to 0.0059, significance level was set at P<or=0.01 corrected for multiple testing), whereas a common 18 locus haplotype within the largest LD block of NTRK2, a 119-kb region containing the 5' flanking region and exons 1-15, was marginally overrepresented in control subjects compared to AD individuals (global P=0.057).
|
17200667 |
2007 |
|
Alcoholic Intoxication, Chronic
|
0.330 |
Biomarker
|
disease |
PSYGENET |
Individually, three SNPs were associated with alcohol dependence and alcohol abuse (AD) (P-value from 0.0019 to 0.0059, significance level was set at P<or=0.01 corrected for multiple testing), whereas a common 18 locus haplotype within the largest LD block of NTRK2, a 119-kb region containing the 5' flanking region and exons 1-15, was marginally overrepresented in control subjects compared to AD individuals (global P=0.057).
|
17200667 |
2007 |
|
Alzheimer's Disease
|
0.290 |
GeneticVariation
|
disease |
BEFREE |
The results of this study indicate that polymorphisms in the selected regions of the NTRK2 gene are unlikely to confer the susceptibility of sAD in the Chinese Han population.
|
23831349 |
2013 |
|
Alzheimer's Disease
|
0.290 |
Biomarker
|
disease |
BEFREE |
Our results suggest that NTRK2 may be a genetic susceptibility gene contributing to AD pathology.
|
17918233 |
2008 |