|
Mental Depression
|
0.600 |
Biomarker
|
disease |
BEFREE |
The results suggest that the BDNF and NTRK2 genes may contribute to the risk of geriatric depression independently and in an interactive manner.
|
20014955 |
2009 |
|
Mental Depression
|
0.600 |
Biomarker
|
disease |
BEFREE |
Brain derived neurotrophic factor (BDNF) and signaling through its tropomyosin-related tyrosine kinase B (TrkB) receptor, represents one of the most promising therapeutic targets for treating depression.
|
30931847 |
2019 |
|
Mental Depression
|
0.600 |
Biomarker
|
disease |
BEFREE |
Brain-derived neurotropic factor (BDNF), a neurotrophic factor, plays important regulatory roles in depression by its high-affinity tropomysin-related kinase B (TrkB) receptor.
|
31660632 |
2020 |
|
Mental Depression
|
0.600 |
Biomarker
|
disease |
BEFREE |
However, the interaction between the BDNF/TRKB system and RAS in depression has not been investigated before.
|
29550391 |
2018 |
|
Mental Depression
|
0.600 |
Biomarker
|
disease |
BEFREE |
To investigate the expression of brain-derived neurotrophic factor(BDNF) and tyrosine kinase B (TrkB) protein in the hippocampus of model rats of comorbid epilepsy and depression.
|
30741614 |
2019 |
|
Mental Depression
|
0.600 |
PosttranslationalModification
|
disease |
BEFREE |
Meanwhile, viral-mediated overexpression of truncated trkB in the ventral hippocampus reduced local ERK42/44 phosphorylation and was sufficient to induce habit-based and depression-like behaviors.
|
29186135 |
2017 |
|
Mental Depression
|
0.600 |
Biomarker
|
disease |
BEFREE |
Polymorphisms of the brain-derived neurotrophic factor (BDNF) have been investigated as candidate genes for post-stroke depression (PSD), and its receptor, neurotrophic tyrosine kinase receptor B (TrkB), has been associated with depression.
|
26641254 |
2015 |
|
Mental Depression
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
We investigated the association of nine polymorphisms throughout the CREB1-BDNF-NTRK2 pathway with lifetime depression, rumination, current depression severity, negative life events, and sad face emotion processing in a three-level design.
|
21215389 |
2011 |
|
Mental Depression
|
0.600 |
Biomarker
|
disease |
BEFREE |
An interactive effect was found between NTRK2 and depression diagnosis maximally affecting the cingulum.
|
22609366 |
2012 |
|
Mental Depression
|
0.600 |
Biomarker
|
disease |
BEFREE |
Several nominally significant gene-based associations were detected, but only DICER1 associated with suicidal behavior in both samples, while only the associations of NTRK2 in the depression sample reached family wise and experiment wise significance.
|
26921221 |
2016 |
|
Bipolar Disorder
|
0.520 |
GeneticVariation
|
disease |
BEFREE |
The results suggest that the NTRK2 gene polymorphism likely plays an essential role in treatment response to mood stabilizers in Han Chinese BP I patients.
|
23315174 |
2013 |
|
Bipolar Disorder
|
0.520 |
Biomarker
|
disease |
BEFREE |
Genes previously involved in the susceptibility to BD (DFNB31, SORCS2, NRXN1, CNTNAP2, GRIN2A, GRM4, GRIN2B), antidepressant action (DEPTOR, CHRNA7, NRXN1), and mood stabilizer or antipsychotic action (NTRK2, CHRNA7, NRXN1) may affect long-term treatment outcome of BD.
|
26297903 |
2016 |
|
Obesity
|
0.440 |
Biomarker
|
disease |
BEFREE |
Accordingly, intraventricular administration of BDNF in rats determines food starvation and body weight loss, while BDNF or its specific receptor NTRK2 knockout mice develop obesity and hyperphagia.
|
15657604 |
2005 |
|
Obesity
|
0.440 |
GeneticVariation
|
disease |
BEFREE |
We detected five rare heterozygous mutations in five different children with obesity: MC4R p.Ile301Thr and SIM1 p.Val326Thrfs*43 mutations that were pathogenic; SIM1 p.Ser343Pro and SH2B1 p.Pro90His mutations that were likely pathogenic; and NTRK2 p.Leu140Phe that was of uncertain significance.
|
29216354 |
2018 |
|
Obesity
|
0.440 |
GeneticVariation
|
disease |
BEFREE |
Functional characterization of human NTRK2 mutations identified in patients with severe early-onset obesity.
|
16702999 |
2007 |
|
Obesity
|
0.440 |
Biomarker
|
disease |
BEFREE |
7,8-Dihydroxyflavone (7,8-DHF), as a high-affinity TrkB receptor agonist, has been extensively explored in many human disorders involving brain-derived neurotrophic factor (BDNF) such as Alzheimer's disease, Parkinson's disease, depression, and obesity.
|
31384856 |
2019 |
|
Autistic Disorder
|
0.410 |
Biomarker
|
disease |
BEFREE |
By substantiating the previously observed increase in BDNF levels in autistic children in a larger patient set, and suggesting a genetic association between NTRK2 and autism, this study integrates evidence from multiple levels supporting the hypothesis that alterations in BDNF/tyrosine kinase B (TrkB) signaling contribute to an increased vulnerability to autism.
|
20662941 |
2010 |
|
Depressive disorder
|
0.400 |
PosttranslationalModification
|
disease |
BEFREE |
Meanwhile, viral-mediated overexpression of truncated trkB in the ventral hippocampus reduced local ERK42/44 phosphorylation and was sufficient to induce habit-based and depression-like behaviors.
|
29186135 |
2017 |
|
Depressive disorder
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
We investigated the association of nine polymorphisms throughout the CREB1-BDNF-NTRK2 pathway with lifetime depression, rumination, current depression severity, negative life events, and sad face emotion processing in a three-level design.
|
21215389 |
2011 |
|
Depressive disorder
|
0.400 |
Biomarker
|
disease |
BEFREE |
However, the interaction between the BDNF/TRKB system and RAS in depression has not been investigated before.
|
29550391 |
2018 |
|
Depressive disorder
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
In this study, we test whether NTRK2 allele variants are associated with mood disorders or depressive disorders in patients with TLE.
|
28550723 |
2017 |
|
Depressive disorder
|
0.400 |
Biomarker
|
disease |
BEFREE |
To investigate the expression of brain-derived neurotrophic factor(BDNF) and tyrosine kinase B (TrkB) protein in the hippocampus of model rats of comorbid epilepsy and depression.
|
30741614 |
2019 |
|
Depressive disorder
|
0.400 |
Biomarker
|
disease |
BEFREE |
The results suggest that the BDNF and NTRK2 genes may contribute to the risk of geriatric depression independently and in an interactive manner.
|
20014955 |
2009 |
|
Depressive disorder
|
0.400 |
Biomarker
|
disease |
BEFREE |
Several nominally significant gene-based associations were detected, but only DICER1 associated with suicidal behavior in both samples, while only the associations of NTRK2 in the depression sample reached family wise and experiment wise significance.
|
26921221 |
2016 |
|
Depressive disorder
|
0.400 |
Biomarker
|
disease |
BEFREE |
Brain derived neurotrophic factor (BDNF) and signaling through its tropomyosin-related tyrosine kinase B (TrkB) receptor, represents one of the most promising therapeutic targets for treating depression.
|
30931847 |
2019 |