|
Alzheimer's Disease
|
0.290 |
Biomarker
|
disease |
BEFREE |
7,8-Dihydroxyflavone (7,8-DHF), as a high-affinity TrkB receptor agonist, has been extensively explored in many human disorders involving brain-derived neurotrophic factor (BDNF) such as Alzheimer's disease, Parkinson's disease, depression, and obesity.
|
31384856 |
2019 |
|
Alzheimer's Disease
|
0.290 |
Biomarker
|
disease |
BEFREE |
Brain-derived neurotrophic factor (BDNF) and its receptor, tropomyosin-related kinase B (TrkB), have emerged as key regulators of brain plasticity and represent disease-modifying targets for several brain disorders, including Alzheimer's disease and major depressive disorder.
|
28831019 |
2017 |
|
Alzheimer's Disease
|
0.290 |
Biomarker
|
disease |
BEFREE |
Moreover, we found that beta-amyloid (Aβ) oligomer exposure could impair BDNF-dependent TrkB endocytosis and Akt activation through enhancing GSK3β activity in cultured hippocampal neurons, which suggested that BDNF-induced TrkB endocytosis and the subsequent signaling were impaired in neuronal model of Alzheimer's disease (AD).
|
25484286 |
2015 |
|
Alzheimer's Disease
|
0.290 |
AlteredExpression
|
disease |
BEFREE |
However, it is unknown whether AD-type neuropathology, soluble Aβ and tau, or levels of BDNF and its receptor tropomyosin-related kinase B (TrkB) correlate with dementia in the oldest-old.
|
26410307 |
2015 |
|
Alzheimer's Disease
|
0.290 |
Therapeutic
|
disease |
RGD |
Treadmill exercise alleviates impairment of spatial learning ability through enhancing cell proliferation in the streptozotocin-induced Alzheimer's disease rats.
|
24877042 |
2014 |
|
Alzheimer's Disease
|
0.290 |
GeneticVariation
|
disease |
BEFREE |
The results of this study indicate that polymorphisms in the selected regions of the NTRK2 gene are unlikely to confer the susceptibility of sAD in the Chinese Han population.
|
23831349 |
2013 |
|
Alzheimer's Disease
|
0.290 |
Biomarker
|
disease |
BEFREE |
Our results suggest that NTRK2 may be a genetic susceptibility gene contributing to AD pathology.
|
17918233 |
2008 |
|
Alzheimer's Disease
|
0.290 |
GeneticVariation
|
disease |
BEFREE |
We found an allele-wise association of rs2072446 on NGFR with familial AD (fAD, p = 0.047), and a genotype-wise association of rs2289656 on NTRK2 with sporadic AD (sAD, p = 0.0036). rs6336 on NTRK1 resulted associated to early-onset sAD in both allele-wise (p = 0.028) and genotype-wise (p = 0.014) analysis, while rs1048218 on BDNF showed allele-wise association with late-onset sAD (p = 0.047).
|
18780967 |
2008 |
|
Alzheimer's Disease
|
0.290 |
Biomarker
|
disease |
LHGDN |
Our results suggest that NTRK2 may be a genetic susceptibility gene contributing to AD pathology.
|
17918233 |
2008 |
|
Alzheimer's Disease
|
0.290 |
GeneticVariation
|
disease |
BEFREE |
We conclude that BDNF and TrkB genes are not contributing significant risk effect among Finnish AD patients.
|
15726264 |
2005 |
|
Alzheimer's Disease
|
0.290 |
AlteredExpression
|
disease |
BEFREE |
Expression of catalytic trkB gene in the striatum and the basal forebrain of patients with Alzheimer's disease: an in situ hybridization study.
|
9121684 |
1997 |