|
Depressed mood
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
Brain-derived neurotropic factor (BDNF), a neurotrophic factor, plays important regulatory roles in depression by its high-affinity tropomysin-related kinase B (TrkB) receptor.
|
31660632 |
2020 |
|
Depressed mood
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
Brain derived neurotrophic factor (BDNF) and signaling through its tropomyosin-related tyrosine kinase B (TrkB) receptor, represents one of the most promising therapeutic targets for treating depression.
|
30931847 |
2019 |
|
Depressed mood
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
To investigate the expression of brain-derived neurotrophic factor(BDNF) and tyrosine kinase B (TrkB) protein in the hippocampus of model rats of comorbid epilepsy and depression.
|
30741614 |
2019 |
|
Depressed mood
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
However, the interaction between the BDNF/TRKB system and RAS in depression has not been investigated before.
|
29550391 |
2018 |
|
Depressed mood
|
0.100 |
PosttranslationalModification
|
phenotype |
BEFREE |
Meanwhile, viral-mediated overexpression of truncated trkB in the ventral hippocampus reduced local ERK42/44 phosphorylation and was sufficient to induce habit-based and depression-like behaviors.
|
29186135 |
2017 |
|
Depressed mood
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
Several nominally significant gene-based associations were detected, but only DICER1 associated with suicidal behavior in both samples, while only the associations of NTRK2 in the depression sample reached family wise and experiment wise significance.
|
26921221 |
2016 |
|
Depressed mood
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
Polymorphisms of the brain-derived neurotrophic factor (BDNF) have been investigated as candidate genes for post-stroke depression (PSD), and its receptor, neurotrophic tyrosine kinase receptor B (TrkB), has been associated with depression.
|
26641254 |
2015 |
|
Depressed mood
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
An interactive effect was found between NTRK2 and depression diagnosis maximally affecting the cingulum.
|
22609366 |
2012 |
|
Depressed mood
|
0.100 |
GeneticVariation
|
phenotype |
BEFREE |
We investigated the association of nine polymorphisms throughout the CREB1-BDNF-NTRK2 pathway with lifetime depression, rumination, current depression severity, negative life events, and sad face emotion processing in a three-level design.
|
21215389 |
2011 |
|
Depressed mood
|
0.100 |
GeneticVariation
|
phenotype |
BEFREE |
Independent SNPs within NTRK2 were associated with SA among depressed patients of the discovery sample that could be confirmed in both the German and African American replication samples.
|
20124106 |
2010 |
|
Depressed mood
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
The results suggest that the BDNF and NTRK2 genes may contribute to the risk of geriatric depression independently and in an interactive manner.
|
20014955 |
2009 |