|
Malignant neoplasm of prostate
|
0.340 |
AlteredExpression
|
disease |
BEFREE |
Nucleobindin 2 has been reported that its high expression is associated with poor outcome and promotes cell migration and lymph node metastasis in breast cancer, colon cancer, and prostate cancer.
|
28714371 |
2017 |
|
Malignant neoplasm of prostate
|
0.340 |
AlteredExpression
|
disease |
BEFREE |
Recent studies indicate that a high level of nesfatin-1/Nucleobindin-2 (NUCB-2) is associated with poor outcome and promotes cell migration in breast cancer and prostate cancer.
|
27150059 |
2016 |
|
Malignant neoplasm of prostate
|
0.340 |
AlteredExpression
|
disease |
BEFREE |
In conclusion, we demonstrated that high NUCB2 mRNA expression correlated with poor overall survival in patients with PCa.
|
24092574 |
2014 |
|
Malignant neoplasm of prostate
|
0.340 |
AlteredExpression
|
disease |
BEFREE |
Our results indicated that the high expression of NUCB2 in PCa was associated with lymph node metastasis, preoperative PSA, Gleason score, and angiolymphatic invasion.
|
23958433 |
2013 |
|
Malignant neoplasm of prostate
|
0.340 |
Biomarker
|
disease |
CTD_human |
Identification of genes potentially involved in the acquisition of androgen-independent and metastatic tumor growth in an autochthonous genetically engineered mouse prostate cancer model.
|
17013881 |
2007 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.300 |
Biomarker
|
disease |
BEFREE |
Altogether, the results suggest the ameliorative effect of nesfatin-1 against T2DM-associated testicular dysfunctions and improved insulin sensitivity along with promoting T production and fertility in T2DM mice.
|
31691259 |
2020 |
|
Obesity
|
0.300 |
Biomarker
|
disease |
BEFREE |
Can Nesfatin-1 Predict Hypertension in Obese Children?
|
31339256 |
2020 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
We also attempted to link these pathways with known aspects of T2D pathophysiology in terms of their association with some of their intermediate traits, namely; adipocyte size, HOMA-B, HOMA-R, Hb1Ac, insulin, glucose-level, TNF-α, IL-6, VLDLs, LDLs, HDLs, and NEFAs.
|
30894049 |
2019 |
|
Obesity
|
0.300 |
Biomarker
|
disease |
BEFREE |
Comments on: Serum nesfatin-1 and galanin concentrations in the adult with metabolic syndrome. Relationships to insulin resistance and obesity.
|
31219502 |
2019 |
|
Obesity
|
0.300 |
Biomarker
|
disease |
BEFREE |
The aim of this study was to evaluate the effects of probiotic yogurt along with a low-calorie diet (LCD) on serum omentin-1, adropin, and nesfatin-1 concentrations in obese and overweight individuals.
|
30232744 |
2019 |
|
Obesity
|
0.300 |
Biomarker
|
disease |
BEFREE |
We confirmed other observations of a strong suppression of release of NEFA from adipose tissue in obesity, tending to normalise circulating NEFA concentrations.
|
30370886 |
2019 |
|
Obesity
|
0.300 |
Biomarker
|
disease |
BEFREE |
Nesfatin-1 appears to be able to contribute to the treatment of obesity and diabetes because of its anorexigenic and antihyperglycemic effects.
|
31369353 |
2019 |
|
Obesity
|
0.300 |
Biomarker
|
disease |
BEFREE |
Serum nesfatin-1 and galanin concentrations in the adult with metabolic syndrome. Relationships to insulin resistance and obesity.
|
30617376 |
2019 |
|
Obesity
|
0.300 |
Biomarker
|
disease |
BEFREE |
In the LHA, an appetite- and reward-related brain area, reduced NUCB2/nesfatin-1 immunoexpression may contribute to dysregulation of homeostatic and/or hedonic feeding behavior and obesity.
|
30625474 |
2019 |
|
Obesity
|
0.300 |
Biomarker
|
disease |
BEFREE |
Nesfatin-1 concentrations were significantly lower in younger (P = .001) and older (P = .009) girls with obesity than in their normal-weight counterparts, without showing significant differences in boys.
|
31507101 |
2019 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.300 |
Biomarker
|
disease |
BEFREE |
This raises the possibility that Nesf-1 dysfunction could be involved in metabolic disorders, particularly in type 2 diabetes mellitus (T2D).
|
30618845 |
2018 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.300 |
Biomarker
|
disease |
BEFREE |
Saxagliptin could upregulate nesfatin-1 secretion and ameliorate insulin resistance and metabolic profiles in type 2 diabetes mellitus.
|
29912623 |
2018 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.300 |
Biomarker
|
disease |
BEFREE |
Effects of acute NEFA manipulation on incretin-induced insulin secretion in participants with and without type 2 diabetes.
|
29732475 |
2018 |
|
Obesity
|
0.300 |
Biomarker
|
disease |
BEFREE |
Loss of Nucleobindin-2 Causes Insulin Resistance in Obesity without Impacting Satiety or Adiposity.
|
30067966 |
2018 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.300 |
Biomarker
|
disease |
BEFREE |
MODY3 experienced a larger decrease in the ratio of NEFA to insulin (NEFA 30-0 / insulin 30-0: -39 [-78; -30] x104) in the early post-prandial period (0-30 minutes) compared to controls and to T2D (-2.0 [-0.6; -6.4] x104; P<0.05).
|
28493909 |
2017 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
In conclusion, the analysis supports a relationship between circulating nesfatin-1 levels and type 2 diabetes, where newly diagnosed type 2 diabetes was associated with an elevated Nesfatin-1 level, and type 2 diabetes patients receiving antidiabetic treatment showed lower circulating nesfatin-1 levels.
|
29445751 |
2017 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.300 |
GeneticVariation
|
disease |
BEFREE |
Association of the polymorphism in NUCB2 gene and the risk of type 2 diabetes.
|
28533821 |
2017 |
|
Obesity
|
0.300 |
Biomarker
|
disease |
BEFREE |
Nesfatin-1 is closely related to obesity and IR in pregnancy.
|
28361552 |
2017 |
|
Obesity
|
0.300 |
GeneticVariation
|
disease |
BEFREE |
The aim of this study was to evaluate NUCB2 gene polymorphism (rs757081) and its association with serum levels of nesfatin-1 in obese and non-obese women with polycystic ovary syndrome (PCOS).
|
26369257 |
2016 |
|
Obesity
|
0.300 |
Biomarker
|
disease |
BEFREE |
Nesfatin-1, originates from the precursor protein nucleobindin 2 (NUCB2) and plays an important role in the development of metabolic syndrome (MetS), including obesity and hypertension.
|
26624852 |
2016 |