leukemia
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Mice that express a NUP98-HOXD13 (NHD13) transgene develop multiple types of leukemia, including myeloid and T and B lymphocyte.
|
31622281 |
2019 |
leukemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
Transgenic mice that express either a NUP98-PHF23 (NP23) or NUP98-HOXD13 (NHD13) fusion in the hematopoietic compartment develop a wide spectrum of leukemias, including myeloid, erythroid, megakaryocytic and lymphoid, at age 9-14 months.
|
31748606 |
2019 |
leukemia
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
2222-2234) provides new mechanistic insight into the molecular basis by which Nup98 promotes gene activation in normal hematopoietic cells and how that process is altered by translocations to cause excess expression of developmental genes in leukemia.
|
29284709 |
2017 |
leukemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
Our data indicate that MLL is crucial for NUP98-HOXA9 leukemia initiation.
|
28210005 |
2017 |
leukemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
Furthermore, <i>Mof</i> inactivation suppressed leukemia development in an <i>NUP98-HOXA9</i>-driven AML model.
|
28202522 |
2017 |
leukemia
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Inactivation of MLL1 leads to decreased expression of genes bound by NHA9 and MLL1 and reverses a gene expression signature found in NUP98-rearranged human leukemias.
|
27889185 |
2016 |
leukemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
Importantly, such aberrations were not only observed in transiently transfected HeLa cells but also in mouse bone marrow cells immortalized by Nup98 fusions and in cells derived from leukemia patients harboring Nup98 fusions.
|
27031510 |
2016 |
leukemia
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Chromosomal rearrangements involving NUP98 gene have been associated with human leukemias such as de novo AML, therapy-related AML (t-AML), myelodysplastic syndrome (MDS), and chronic myeloid leukemia (CML).
|
26418229 |
2016 |
leukemia
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Furthermore, the age-associated accumulation of somatic mutations that occurs in the Nup98-HOXD13 (NHD13) mouse model of leukemia progression was significantly elevated by co-expression of a PKR transgene, whereas knockout of PKR expression or pharmacologic inhibition of PKR activity reduced the frequency of spontaneous mutations in vivo.
|
26202421 |
2015 |
leukemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
Critical role of retinoid/rexinoid signaling in mediating transformation and therapeutic response of NUP98-RARG leukemia.
|
25510432 |
2015 |
leukemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
In contrast, neither NUP98-NSD1 nor FLT3-ITD single transduced cells were able to initiate leukemia.
|
24951466 |
2014 |
leukemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
NUP98-PHF23 is a chromatin-modifying oncoprotein that causes a wide array of leukemias sensitive to inhibition of PHD histone reader function.
|
24535671 |
2014 |
leukemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
NUP98 is known to be fused to at least 28 different partner genes in patients with hematopoietic malignancies, including acute myeloid leukemia, chronic myeloid leukemia in blast crisis, myelodysplastic syndrome, acute lymphoblastic leukemia, and bilineage/biphenotypic leukemia.
|
21948299 |
2011 |
leukemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
These data suggest that RAE1 orchestrates NUP98-mediated leukemogenesis and raise the possibility that targeting this negative feedback loop may provide a new strategy for the therapy of aggressive leukemias.
|
21467841 |
2011 |
leukemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
Together, these findings reveal a major role for Smad4 in the negative regulation of leukemia initiation and maintenance induced by HOXA9/NUP98-HOXA9 and provide strong evidence that antagonizing Smad4 stabilization by these oncoproteins might be a promising novel therapeutic approach in leukemia.
|
21471525 |
2011 |
leukemia
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Rearrangements of the NUP98 gene in human leukemia result in the expression of numerous fusion oncoproteins whose effect on nucleocytoplasmic trafficking is poorly understood.
|
20233715 |
2010 |
leukemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
This FISH assay is useful for diagnostic screening of NUP98-positive leukemias.
|
19665072 |
2009 |
leukemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
Mechanistically, NUP98-PHD fusions act as 'chromatin boundary factors', dominating over polycomb-mediated gene silencing to 'lock' developmentally critical loci into an active chromatin state (H3K4me3 with induced histone acetylation), a state that defined leukaemia stem cells.
|
19430464 |
2009 |
leukemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
Some of these genes (Hoxa5, Hoxa9, Flt3) are deregulated in NUP98/HHEX-induced murine leukemia as well as in human blasts carrying this fusion and might represent bona fide therapeutic targets.
|
18388181 |
2008 |
leukemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
NUP98 has been involved in multiple recurrent chromosome rearrangements in leukemia.
|
18084320 |
2008 |
leukemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
To elucidate the leukemogenic potential of NUP98-PMX1, we compared the effects of PMX1 and NUP98-PMX1 and, through strategic mutations, the involvement of the SRE in NUP98-PMX1-mediated leukemia.
|
18604245 |
2008 |
leukemia
|
0.100 |
AlteredExpression
|
disease |
LHGDN |
Leukemic transformation in mice expressing a NUP98-HOXD13 transgene is accompanied by spontaneous mutations in Nras, Kras, and Cbl.
|
18566322 |
2008 |
leukemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
Interestingly, an engineered NUP98-HOXA10 (NA10) fusion can induce a several hundred-fold expansion of HSCs in vitro and NA10 and the AML-associated fusion gene NUP98-HOXD13 (ND13) have a virtually indistinguishable ability to transform myeloid progenitor cells in vitro and to induce leukemia in collaboration with MEIS1 in vivo.
|
17712416 |
2007 |
leukemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
Retroviral integration site analysis identifies ICSBP as a collaborating tumor suppressor gene in NUP98-TOP1-induced leukemia.
|
16939812 |
2006 |
leukemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
The NUP98-HOXA9 fusion transcript was detected by RT-PCR, suggesting its role in the malignant transformation as it has been postulated for other t(7;11)-associated leukemias.
|
15721637 |
2005 |