|
Other specified nonscarring hair loss
|
0.200 |
Biomarker
|
disease |
MGD |
|
|
|
|
ATRICHIA WITH PAPULAR LESIONS
|
0.200 |
Biomarker
|
disease |
MGD |
|
|
|
|
Colon Carcinoma
|
0.090 |
Biomarker
|
disease |
BEFREE |
To examine this idea, we used a human colon carcinoma cell line (LoVo) as a model system and measured ornithine decarboxylase (ODC), because this is the rate-limiting enzyme for the formation of polyamines, which are thought to be key factors in regulating cell growth.
|
1324153 |
1992 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
A significant correlation was noted between ODC activity and mRNA expression in cancerous and noncancerous tissues of the esophagus, stomach, and colon, thereby suggesting that increased steady-state mRNA may be responsible for the high ODC activity in these tumors.
|
1423312 |
1992 |
|
Liver neoplasms
|
0.040 |
AlteredExpression
|
group |
BEFREE |
We examined the level of expression of ODC mRNA together with ODC activity in surgically excised human cancers, including esophagus, stomach, colon, and liver tumors, the objective being to determine whether the ODC mRNA level correlates with enhancement of ODC activity in these cancers.
|
1423312 |
1992 |
|
Esophageal Neoplasms
|
0.020 |
AlteredExpression
|
group |
BEFREE |
Elevated expression of the ornithine decarboxylase gene in human esophageal cancer.
|
1423312 |
1992 |
|
Esophageal carcinoma
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
Elevated expression of the ornithine decarboxylase gene in human esophageal cancer.
|
1423312 |
1992 |
|
Malignant neoplasm of esophagus
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
Mechanisms sustaining high ODC mRNA levels in esophageal cancers may be an enhancement of the promoter activity of this gene or stabilization of the mRNA.
|
1423312 |
1992 |
|
Malignant tumor of colon
|
0.390 |
Biomarker
|
disease |
BEFREE |
Recently, elevated ODC activity and polyamine levels have been suggested as biological markers for human colon cancer.
|
1573975 |
1992 |
|
Colon Carcinoma
|
0.090 |
Biomarker
|
disease |
BEFREE |
Recently, elevated ODC activity and polyamine levels have been suggested as biological markers for human colon cancer.
|
1573975 |
1992 |
|
Ulcerative Colitis
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
In the active stage of UC, the mucosal level of mRNA coding for ornithine decarboxylase was lower than in the remission stage of UC or in the controls.
|
1590311 |
1992 |
|
Colonic Neoplasms
|
0.310 |
GeneticVariation
|
group |
BEFREE |
Overexpression of the ornithine decarboxylase (ODC) gene may be important to the development and maintenance of colonic neoplasms, as well as tumors in general.
|
1598217 |
1992 |
|
Osteosarcoma
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
Effects of parathyroid hormone on ornithine decarboxylase activity in human osteosarcoma cells.
|
1654784 |
1991 |
|
Osteosarcoma of bone
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
Effects of parathyroid hormone on ornithine decarboxylase activity in human osteosarcoma cells.
|
1654784 |
1991 |
|
Childhood Osteosarcoma
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
Effects of parathyroid hormone on ornithine decarboxylase activity in human osteosarcoma cells.
|
1654784 |
1991 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Tumor DNA content was greater in the HT29 H/N group compared to the N/N group (P less than 0.05) and tumor ornithine decarboxylase activity in the WiDr H/N group was greater than the N/N animals (P less than 0.002).
|
1657557 |
1991 |
|
Malignant neoplasm of breast
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
These results suggest that different transcriptional and post-transcriptional mechanisms control the regulation of ODC gene expression in breast cancer cell lines.
|
1663805 |
1991 |
|
Breast Carcinoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
These results suggest that different transcriptional and post-transcriptional mechanisms control the regulation of ODC gene expression in breast cancer cell lines.
|
1663805 |
1991 |
|
Malignant tumor of colon
|
0.390 |
Biomarker
|
disease |
BEFREE |
Increased levels of phorbin, c-myc, and ornithine decarboxylase RNAs in human colon cancer.
|
1693276 |
1990 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
About 47% and 16% of these tumor samples also showed increased levels of ODC (mean 3.1-fold) and beta-actin (mean 1.6-fold) RNA, respectively.
|
1693276 |
1990 |
|
Colon Carcinoma
|
0.090 |
Biomarker
|
disease |
BEFREE |
Increased levels of phorbin, c-myc, and ornithine decarboxylase RNAs in human colon cancer.
|
1693276 |
1990 |
|
Tumor Cell Invasion
|
0.090 |
AlteredExpression
|
phenotype |
BEFREE |
The increased levels of c-myc, ODC, and beta-actin RNA did not correlate with the extent of tumor invasion.
|
1693276 |
1990 |
|
Multiple Myeloma
|
0.030 |
AlteredExpression
|
disease |
BEFREE |
We have now employed the PCR combined with reverse transcription to determine semiquantitatively ODC gene dosage and the amounts of heterogeneous nuclear (hn) RNA and of mature mRNA of the enzyme in parental and alpha-difluoromethylornithine-resistant human myeloma cells.
|
1898373 |
1991 |
|
Colorectal Neoplasms
|
0.330 |
AlteredExpression
|
group |
BEFREE |
Ornithine decarboxylase (ODC) is a rate-limiting enzyme in the synthesis of these amines, and activity is elevated in colorectal tumors and polyps.
|
1976038 |
1990 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Investigation of the expression of ODC in colorectal neoplasia reveals a consistent increase in mRNA expression compared with normal adjacent mucosa and control mucosa, ranging from 1.3- to 12.2-fold.No amplification of the loci was seen.
|
1976038 |
1990 |