ODC1, ornithine decarboxylase 1, 4953

N. diseases: 184; N. variants: 2
Source: ALL
Variant Gene Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs2302615
rs2302615
Entrez Id: 4953;100302743;101929715
Gene Symbol: ODC1;SNORA80B;ODC1-DT
ODC1;SNORA80B;ODC1-DT
CUI: C0009402
Disease:
Colorectal Carcinoma 		0.020 GeneticVariation BEFREE Meta-analysis showed association between SNPs rs6983267, rs11694911 and rs2302615 with CRC risk reduction (All P<0.05). 29425227 2018
dbSNP: rs2302615
rs2302615
Entrez Id: 4953;100302743;101929715
Gene Symbol: ODC1;SNORA80B;ODC1-DT
ODC1;SNORA80B;ODC1-DT
CUI: C0009402
Disease:
Colorectal Carcinoma 		0.020 GeneticVariation BEFREE The primary outcome was colorectal cancer-specific survival dependent on ODC1 (rs2302615) genotype (GG versus GA/AA). 19789310 2009
dbSNP: rs2302615
rs2302615
Entrez Id: 4953;100302743;101929715
Gene Symbol: ODC1;SNORA80B;ODC1-DT
ODC1;SNORA80B;ODC1-DT
CUI: C0007102
Disease:
Malignant tumor of colon 		0.010 GeneticVariation BEFREE Site-specific analysis showed association between SNPs rs1799853 and rs2302615 with reduced colon cancer risk only (P = 0.01 and P = 0.004, respectively), however neither reached significance threshold following multiple test correction. 29425227 2018
dbSNP: rs2302615
rs2302615
Entrez Id: 4953;100302743;101929715
Gene Symbol: ODC1;SNORA80B;ODC1-DT
ODC1;SNORA80B;ODC1-DT
CUI: C0699790
Disease:
Colon Carcinoma 		0.010 GeneticVariation BEFREE Site-specific analysis showed association between SNPs rs1799853 and rs2302615 with reduced colon cancer risk only (P = 0.01 and P = 0.004, respectively), however neither reached significance threshold following multiple test correction. 29425227 2018
dbSNP: rs2302616
rs2302616
Entrez Id: 4953;100302743;101929715
Gene Symbol: ODC1;SNORA80B;ODC1-DT
ODC1;SNORA80B;ODC1-DT
CUI: C0700095
Disease:
Central neuroblastoma 		0.010 GeneticVariation BEFREE Children with the minor T allele at rs2302616 of the ODC gene with relapsed or refractory NB had higher levels of urinary polyamine markers and responded better to therapy containing DFMO, compared to those with the major G allele at this locus. 26018967 2015
dbSNP: rs2302616
rs2302616
Entrez Id: 4953;100302743;101929715
Gene Symbol: ODC1;SNORA80B;ODC1-DT
ODC1;SNORA80B;ODC1-DT
CUI: C0027819
Disease:
Neuroblastoma 		0.010 GeneticVariation BEFREE Children with the minor T allele at rs2302616 of the ODC gene with relapsed or refractory NB had higher levels of urinary polyamine markers and responded better to therapy containing DFMO, compared to those with the major G allele at this locus. 26018967 2015
dbSNP: rs2302616
rs2302616
Entrez Id: 4953;100302743;101929715
Gene Symbol: ODC1;SNORA80B;ODC1-DT
ODC1;SNORA80B;ODC1-DT
CUI: C4086165
Disease:
Childhood Neuroblastoma 		0.010 GeneticVariation BEFREE Children with the minor T allele at rs2302616 of the ODC gene with relapsed or refractory NB had higher levels of urinary polyamine markers and responded better to therapy containing DFMO, compared to those with the major G allele at this locus. 26018967 2015
dbSNP: rs2302615
rs2302615
Entrez Id: 4953;100302743;101929715
Gene Symbol: ODC1;SNORA80B;ODC1-DT
ODC1;SNORA80B;ODC1-DT
CUI: C0001430
Disease:
Adenoma 		0.010 GeneticVariation BEFREE Previous studies suggest that a single-nucleotide polymorphism (SNP) in the promoter of the ODC gene (rs2302615) may be associated with adenoma risk and/or response to aspirin chemoprevention. 21930798 2011
dbSNP: rs2302615
rs2302615
Entrez Id: 4953;100302743;101929715
Gene Symbol: ODC1;SNORA80B;ODC1-DT
ODC1;SNORA80B;ODC1-DT
CUI: C4722085
Disease:
Malignant neoplasm of colon and/or rectum 		0.010 GeneticVariation BEFREE The primary outcome was colorectal cancer-specific survival dependent on ODC1 (rs2302615) genotype (GG versus GA/AA). 19789310 2009
dbSNP: rs2302615
rs2302615
Entrez Id: 4953;100302743;101929715
Gene Symbol: ODC1;SNORA80B;ODC1-DT
ODC1;SNORA80B;ODC1-DT
CUI: C0678222
Disease:
Breast Carcinoma 		0.010 GeneticVariation BEFREE This study investigated whether the ODC +316 G > A polymorphism (rs2302615) was associated with the risk of developing breast cancer. 19225907 2009
dbSNP: rs2302615
rs2302615
Entrez Id: 4953;100302743;101929715
Gene Symbol: ODC1;SNORA80B;ODC1-DT
ODC1;SNORA80B;ODC1-DT
CUI: C0006142
Disease:
Malignant neoplasm of breast 		0.010 GeneticVariation BEFREE This study investigated whether the ODC +316 G > A polymorphism (rs2302615) was associated with the risk of developing breast cancer. 19225907 2009