Disease: Endothelial dysfunction ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0856169
Disease: Endothelial dysfunction
Endothelial dysfunction 		0.100 Biomarker phenotype BEFREE Ox- LDL through LOX-1, in endothelial cells, causes increase in leukocyte adhesion molecules, activates pathways of apoptosis, increases reactive oxygen species and cause endothelial dysfunction. 29737246 2019
CUI: C0856169
Disease: Endothelial dysfunction
Endothelial dysfunction 		0.100 Biomarker phenotype BEFREE Whether galectin-3 induces endothelial dysfunction through modulation of LOX-1-mediated signaling remains unclear. 30963716 2019
CUI: C0856169
Disease: Endothelial dysfunction
Endothelial dysfunction 		0.100 Biomarker phenotype BEFREE Background When the lectinlike oxidized low-density lipoprotein (ox LDL) receptor-1 ( LOX -1), a scavenger receptor for ox LDL , binds ox LDL , processes leading to endothelial dysfunction and inflammation are promoted. 30744454 2019
CUI: C0856169
Disease: Endothelial dysfunction
Endothelial dysfunction 		0.100 Biomarker phenotype BEFREE The LOX-1-ox-LDL interaction induces endothelial dysfunction, leukocyte adhesion, macrophage-derived foam cell formation, smooth muscle cell proliferation and migration, and platelet activation. 30381837 2019
CUI: C0856169
Disease: Endothelial dysfunction
Endothelial dysfunction 		0.100 GeneticVariation phenotype BEFREE We aimed to investigate the relationships between serum asymmetric dimethyl arginine (ADMA), LOX-1, and Apelin-13 levels, which are known to act over nitric oxide with endothelial dysfunction and cardiac morphology as well as with each other in hemodialysis patients. 29205940 2018
CUI: C0856169
Disease: Endothelial dysfunction
Endothelial dysfunction 		0.100 AlteredExpression phenotype BEFREE Ginkgolide B ameliorates oxidized low-density lipoprotein-induced endothelial dysfunction via modulating Lectin-like ox-LDL-receptor-1 and NADPH oxidase 4 expression and inflammatory cascades. 30136446 2018
CUI: C0856169
Disease: Endothelial dysfunction
Endothelial dysfunction 		0.100 Biomarker phenotype BEFREE Lectin-like oxidized low-density lipoprotein receptor-1 promotes endothelial dysfunction in LDL receptor knockout background. 29096854 2017
CUI: C0856169
Disease: Endothelial dysfunction
Endothelial dysfunction 		0.100 AlteredExpression phenotype BEFREE These findings demonstrated for the first time that BBR could prevent the oxLDL and TNFα - induced LOX1 expression and oxidative stress, key events that lead to NOX, MAPK/Erk1/2 and NF-κB activation linked to endothelial dysfunction. 28511903 2017
CUI: C0856169
Disease: Endothelial dysfunction
Endothelial dysfunction 		0.100 GeneticVariation phenotype BEFREE The aim of the study was to investigate the relationship between the rs1050283 polymorphism in the 3'-UTR of OLR1/LOX-1 gene and endothelial dysfunction in 178 never-treated hypertensive patients and 36 healthy subjects. 23054405 2014
CUI: C0856169
Disease: Endothelial dysfunction
Endothelial dysfunction 		0.100 Biomarker phenotype BEFREE These results provide the first evidence that plasma from PE generates superoxide via a LOX1-NOX2-mediated pathway and downregulates endothelial KCa3.1, which may contribute to endothelial dysfunction and vasculopathy in preeclampsia. 23261940 2013
CUI: C0856169
Disease: Endothelial dysfunction
Endothelial dysfunction 		0.100 Biomarker phenotype BEFREE There are many scavenger receptors for ox-LDL, among which LOX-1 seems to be important for the induction of endothelial dysfunction and the other subsequent events that lead to the formation of atheromatous plaque. 23934117 2013
CUI: C0856169
Disease: Endothelial dysfunction
Endothelial dysfunction 		0.100 Biomarker phenotype BEFREE These preliminary data would suggest that in ICVD patients the LOX-1 isoform that induces internalization of ox-LDL is more frequent and a cascade of events responsible for endothelial dysfunction and injury. 19929426 2010
CUI: C0856169
Disease: Endothelial dysfunction
Endothelial dysfunction 		0.100 Biomarker phenotype BEFREE LOX-1 has been demonstrated to contribute not only to endothelial dysfunction, but also to atherosclerotic-plaque formation, myocardial infarction and intimal thickening after balloon injury. 19801851 2009
CUI: C0856169
Disease: Endothelial dysfunction
Endothelial dysfunction 		0.100 Biomarker phenotype BEFREE Lectin-like oxidized LDL receptor-1 (LOX-1) is the major endothelial receptor for oxidized LDL (oxLDL), and uptake of oxLDL through LOX-1 induces ED. 15855339 2005
CUI: C0856169
Disease: Endothelial dysfunction
Endothelial dysfunction 		0.100 Biomarker phenotype BEFREE Therapy of endothelial dysfunction through LOX-1 receptor antagonism will be an interesting avenue to explore. 14656932 2004
CUI: C0856169
Disease: Endothelial dysfunction
Endothelial dysfunction 		0.100 Biomarker phenotype BEFREE Whether CRP may regulate endothelial LOX-1 and induce endothelial dysfunction through this receptor is unknown. 15472120 2004
CUI: C0856169
Disease: Endothelial dysfunction
Endothelial dysfunction 		0.100 Biomarker phenotype BEFREE LOX-1, the receptor for oxidized low-density lipoprotein identified from endothelial cells: implications in endothelial dysfunction and atherosclerosis. 12163130 2002