|
Pain, Postoperative
|
0.100 |
GeneticVariation
|
phenotype |
BEFREE |
COMT and OPRM1 were the most identified genetic polymorphisms associated with postoperative pain intensity.
|
31080143 |
2019 |
|
Pain, Postoperative
|
0.100 |
GeneticVariation
|
phenotype |
BEFREE |
In this meta-analysis, the results indicate the OPRM1 A118G polymorphism was associated with the opioid requirement and the adverse effects in pain treatment especially in postoperative pain.
|
31337162 |
2019 |
|
Pain, Postoperative
|
0.100 |
GeneticVariation
|
phenotype |
BEFREE |
Influence of OPRM1 Polymorphism on Postoperative Pain After Intrathecal Morphine Administration in Italian Patients Undergoing Elective Cesarean Section.
|
28591085 |
2018 |
|
Pain, Postoperative
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
Recent genetic studies have reported associations of genetic variants in catechol-O-methyltransferase (COMT), brain-derived neurotrophic factor (BDNF), voltage-gated channel alpha subunit 11 (SCN11A) and μ-opioid receptor (OPRM1) genes with postoperative pain.
|
29994939 |
2018 |
|
Pain, Postoperative
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
Recently, (±)-N-(3-fluoro-1-phenethylpiperidine-4-yl)-N-phenyl propionamide (NFEPP), a newly designed μ-opioid receptor (MOR) agonist with a low pKa, has been shown to produce injury-restricted analgesia in models of inflammatory and postoperative pain, without exhibiting typical opioid side effects.
|
29994988 |
2018 |
|
Pain, Postoperative
|
0.100 |
GeneticVariation
|
phenotype |
BEFREE |
OPRM1-rs1799971" genes_norm="4988">A118G polymorphism (A > G, rs1799971) is associated with interindividual variability in both response to postoperative pain and opioid treatment.
|
30323865 |
2018 |
|
Pain, Postoperative
|
0.100 |
GeneticVariation
|
phenotype |
BEFREE |
Using multiple regression analyses, four single-nucleotide polymorphisms of COMT (rs6269, rs4633, rs4818, and rs4680), their haplotypes, and diplotypes were considered for their interactions with A118G of OPRM1 regarding postoperative pain and opioid consumption.
|
27903758 |
2017 |
|
Pain, Postoperative
|
0.100 |
GeneticVariation
|
phenotype |
BEFREE |
OPRM1 and ABCB1 polymorphisms and their effect on postoperative pain relief with piritramide.
|
26681082 |
2015 |
|
Pain, Postoperative
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
The role of hydromorphone and OPRM1 in postoperative pain relief with hydrocodone.
|
23703421 |
2014 |
|
Pain, Postoperative
|
0.100 |
GeneticVariation
|
phenotype |
BEFREE |
The associations between OPRM 1 and COMT genotypes and postoperative pain, opioid use, and opioid-induced sedation.
|
22718527 |
2013 |
|
Pain, Postoperative
|
0.100 |
GeneticVariation
|
phenotype |
BEFREE |
The OPRM1 A118G polymorphism may help predict individuals' response to epidural labor analgesia and so optimize postoperative pain control.
|
23909491 |
2013 |
|
Pain, Postoperative
|
0.100 |
GeneticVariation
|
phenotype |
BEFREE |
This study shows that the OPRM1 118A>G polymorphism affects postoperative pain response in heterozygous patients: they have a different postoperative pain response than patients with wild-type genes, which may affect the efficacy of the analgesic therapy.
|
22230405 |
2012 |
|
Pain, Postoperative
|
0.100 |
GeneticVariation
|
phenotype |
BEFREE |
Lack of association of OPRM1 and ABCB1 single-nucleotide polymorphisms to oxycodone response in postoperative pain.
|
21383334 |
2012 |
|
Pain, Postoperative
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
We conclude that OPRM1 gene analysis may help predict individual opioid sensitivity and so optimise postoperative pain control.
|
20003118 |
2010 |
|
Pain, Postoperative
|
0.100 |
GeneticVariation
|
phenotype |
BEFREE |
Ethnicity and OPRM variant independently predict pain perception and patient-controlled analgesia usage for post-operative pain.
|
19545447 |
2009 |