OPRM1, opioid receptor mu 1, 4988

N. diseases: 370; N. variants: 42
Disease: Stress, Psychological ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0038443
Disease: Stress, Psychological
Stress, Psychological 		0.030 Biomarker disease BEFREE Rats exposed to early life stress (MS360) had increased opioid receptor gene (Oprm1, Oprd1 and Oprk1) expression in the dorsal striatum. 28511993 2017
CUI: C0038443
Disease: Stress, Psychological
Stress, Psychological 		0.030 Biomarker disease BEFREE This current study is the first to find an interaction between OPRM1 and life stress that is associated with depression. 24766998 2014
CUI: C0038443
Disease: Stress, Psychological
Stress, Psychological 		0.030 Biomarker disease BEFREE There is increasing evidence that neuropeptides such as a substance P, neurotrophins or beta-endorphin, an endogenous agonist for mu-opioid receptor, are involved in the pathogenesis of atopic dermatitis in which mental stress and scratching deteriorate the disease. mu-Opioid receptor, a G-protein-coupled receptor, can be downregulated and internalized by agonists and other factors in vitro. 15724090 2005